Description overdue on 09/10/2013

Antibiotic . The active substance is representative of the class   cephalosporins   4th generation. The principle of the main effects is aimed at destruction of the cell walls of the microbial cells; drug bactericidal effect. The drug exhibits high antibacterial activities against strains that are resistant to cephalosporins 3rd generation aminoglycosides . Active substance penetrates rapidly enough gram microbial cells, while possessing a high resistance to hydrolysis by many beta-lactamase. The main target within the cell to cefepime is a penicillin-binding protein. Antibiotic Cefepime effect on gram-positive and gram-negative bacteria flora in vitro and in vivo: streptococci, enterobacteria, Escherichia coli, Klebsiella, Clostridium, Proteus, and others. The drug comes in powder form, from which the prepared solution for intravenous, intramuscular administration. Cefepime in tablets is not issued. Cefepime price depends on the dosage of the active substance (average cost of 100-200 rubles).

Indications:

Cefepime is an antibiotic prescribed for severe and moderate current pneumonia Caused by streptococci, enterococci, Klebsiella and other sensitive to the drug by microorganisms. Instructions for use contains the following indications for use of the drug Cefepime: infections of the urinary tract (complicated and uncomplicated forms) febrile neutropenia , Uncomplicated infections of the skin and the adjoining soft tissue. The drug is recommended for use in complicated intra-abdominal infections lesions (in the complex therapy with metronidazole).

Contraindications:

Cefepime is not prescribed for the individual hypersensitivity to the active component, penicillins, cephalosporins, beta-lactams. The drug is not indicated for children younger than 2 months.

Side effect:

Cefepime may cause allergic reactions such as fever, itching, erythematous rash   skin, toxic epidermal necrolysis, erythema multiforme exudative, anaphylactoid reactions . Against the background of antibiotic therapy offers the possibility of a positive Coombs reaction. When administered intramuscularly, tenderness and redness in the area of ​​administration; rarely develop phlebitis after intravenous infusion. Nervous system: convulsions , Dizziness, paresthesia, confusion, a feeling of anxiety and worry , headache. Urinary Tract:   functional disturbances in the renal system. The digestive tract:   dyspeptic symptoms, pseudomembranous colitis , Constipation, epigastric pain, nausea, vomiting. Bodies of blood:   rarely observed bleeding on the background of antibacterial therapy,   anemia , Leukopenia, a reduction in the number of platelets, neutrophils. From the side of respiratory system   there is a cough. Cardiovascular system:   peripheral edema, palpitations, shortness of breath. Indicators of laboratory and instrumental methods of research: hypercalcemia , Increased prothrombin time, hyperbilirubinemia , Increased levels of urea and of hepatic enzymes alkaline phosphatase register hypercreatininemia . The treatment may develop oropharyngeal candidiasis, asthenia, chest pain, superinfection Pain in the back and throat. Reviews on Cefepime indicate a good tolerability of antibiotic prescriptions in compliance with the attending physician.

Mode of application:

Cefepime is administered by intravenous infusion (duration of infusion should be at least half an hour). In some cases the medicament may be intramuscular (diseases of the genitourinary system, caused by E. coli). Treatment for pneumonia: intravenous antibiotic 1-2 grams twice a day for 10 days. Empirical therapy febrile neutropenia : Administered every 8 hours and 2 grams of the drug intravenously, the treatment is carried out before complete resolution of disease (mean 10 days) .  Treatment of infectious lesions of the urinary tract: 0 intravenous infusion, 5-1 grams of cefepime every 12 hours, a course of antibiotic therapy is designed for 7-10 days .  In severe diseases of the above amount of the drug is increased to 2 grams, the treatment is designed for 10 days .  Hemodialysis patients on the first day of antibiotic treatment administered 1 gram of cefepime daily thereafter poured over 0, 5 grams (with febrile neutropenia, the dose was increased to 1 gram) .  The drug is recommended to be administered immediately after completion of the hemodialysis .  As cefepime diluted for intravenous injection: before pouring the powder was dissolved in 5% solution dektrozy (use of sodium chloride 0, 9%) until complete dissolution .  Before intramuscular formulation diluted in water for injection ad hoc with benzyl alcohol or a paraben .  Perhaps the use of lidocaine concentrations of 0, 5, and 1% .

Special instructions:

Cefepime in tablets is not issued .  The drug is cancel the development of pseudomembranous colitis with long flowing diarrhea syndrome (recommended switching to metronidazole and vancomycin) .  Patients with a history of allergic response to penicillin, the formation of cross-allergic hypersensitivity .  Patients with diseases of the liver, kidney requires regular monitoring of the level of concentration of active substance in the blood (the correction mode is performed in accordance with the level QC) .  When mixed form of anaerobic-aerobic infections recommended supplementation of antibacterial drugs to complete the identification of the main pathogens .  The treatment offers the possibility of a false positive result when testing for sugar in the urine .  Ready antibiotic solution can be stored for more than one day at room temperature (kept in the refrigerator for a period increases to 7 days) .  The antibacterial activity of the drug is lost in changing the color of the solution prepared .  Analogs of the drug Cefepime : Maxipime . Ladef . ChainsWe . Movizar . Efipim . Buy Cefepime at any pharmacy chain (obligatory presentation of a prescription form with a doctor's prescription).

Drug Interactions:

Cefepime is able to increase ototoxicity   and strengthen the side effects on the renal system, while the treatment of aminoglycosides. Antibiotic incompatible with heparin and other antimicrobials. The medicament unacceptable administered together with a solution of metronidazole.