Description overdue on 13.12.2011

Antibacterial drugs, lincosamides . It has expressed bacteriostatic effects   a large number of microorganisms. The mechanism of drug action based on inhibition of protein synthesis in the cell of the microbe. In some cocci has gramopolozhitelnye bactericidal action . Among lincomycin   clindamycin, and notes cross-resistance. Effectively used in asymptomatic carriers of diphtheria . Following oral administration of clindamycin almost completely and rapidly absorbed in the digestive tract. Food intake has no effect on the absorption of the drug. It is metabolized in the liver system, excreted in the urine, feces. Hemodialysis during injection of the drug is not effective. Clindamycin is available in tablet form, as a solution, a gel for topical application, vaginal cream, granules for syrup.

Indications:

Topical Clindamycin used for treatment of vaginosis caused microflora sensitive to the drug. Externally prescribed for ordinary acne . Systemic Clindamycin is indicated for the treatment of severe infectious and inflammatory diseases: pneumonia . peritonitis , Purulent soft tissue, skin, wounds, empyema . lung abscess . osteomyelitis . adnexitis, endometritis . The drug is used for the prevention of intra-abdominal abscesses, peritonitis after traumatic injuries of bowel perforation (combination therapy with aminoglycosides). Clindamycin is used in the extraction of teeth as the prevention of inflammatory processes. In infections caused by microorganisms resistant to penicillin, clindamycin antibiotic acts reserve.

Contraindications:

Clindamycin is not prescribed for allergy to lincomycin and components of the drug. In the systemic application contraindications are severe functional impairment in renal and liver systems, bronchial asthma, myasthenia . ulcerative colitis . The drug is not used in pediatrics (up to 1 month), the elderly, during pregnancy and breastfeeding.

Side effect:

Cardiovascular system : Rapid intravenous administration of the drug can cause a sharp drop in blood pressure, weakness, dizziness. Digestive system : When administered intravenously marked metallic taste in the mouth, dyspepsia, events esophagitis , Elevated liver enzymes, increased bilirubin may develop jaundice . Hematopoietic system : agranulocytosis , Neutropenia, reversible leukopenia, thrombocytopenia. Intravenous administration can lead to the development phlebitis , Abscess formation, infiltrate. When applied topically, in some cases, there is contact dermatitis in the zone of application. Application vaginal form of the drug may cause vaginitis . cervicitis , Vulvovaginal irritation in the area.

Mode of application:

In order to prevent the irritant effect of the drug on the wall of the esophagus is recommended to take Clindamycin capsules, drinking plenty of fluids during meals .  Adults appoint 1 capsule every 6 hours as inflammatory lung disease, moderate .  In more severe cases, the dosage is increased up to 450 mg .  When infection of cervical chlamydia take medication for 2 weeks 4 times a day, 45 mg .  Babies take medication as a syrup: a vial of granules necessary to add 60 ml of water .  Intravenous and intramuscular injection is carried out for at least 4 days, then 2 days is recommended to take the encapsulated form of the drug: 450 mg every six hours .  Intravenous administration of the preparation may be a rate of not more than 30 mg per Minute .  Simultaneous intramuscular administration of the drug in a dose of more than 600 mg are not permissible .  In preparing an injection solution as a solvent is saline, water for injection, dextrose 5% .  Ready solutions are effective for 2 days .  For external use the gel is applied twice a day .  Vaginal form used at night, treatment 3 days .

Special instructions:

In the pathology of renal, hepatic system use of the drug begin with minimal doses of controlled concentration of clindamycin in the blood. With prolonged use requires regular monitoring of blood counts, kidney and liver. Within three weeks after the application of the drug may develop pseudomembranous colitis , At-risk elderly, malnourished patients. In severe colitis recommended appointment vancomycin   4 times daily 125-500 mg. Correction hemostasis   performed by introducing protein solutions, plasma expanders, electrolytes. The risk of side effects is reduced by deep intramuscular injection. Clindamycin is able to penetrate through the placental barrier, excreted in breast milk. The use of vaginal forms of the drug during pregnancy is permitted only when a thorough assessment of the possible risk of side effects of clindamycin on the fetus and the importance of the therapeutic effect for women.

Drug Interactions:

Concomitant use with opioids   dampening effect on the respiratory system. Clindamycin potentiates the effect of drugs that block neuromuscular transmission. Clindamycin competitively inhibits the action chloramphenicol   and macrolides . When concomitant administration of ciprofloxacin . metronidazole . ceftazidime   marked synergy. The drug reduces the bacterial activity aminoglycosides .