Description overdue on 24.05.2012

TB drugs . Main substance is capable to penetrate inside the is actively growing cells of mycobacteria, to inhibit the process of of synthesizing of RNA, to violate the during the of cellular metabolism, cause the death of and termination of reproduction of microorganisms. Thus, Ethambutol bacteriostatic. The drug acts only on intensively dividing cells of bacteria. The drug is able to inhibit the growth and reproduction of mycobacteria are resistant to ethionamide, PAS, isoniazid . kanamycin . streptomycin . Resistant mycobacteria growing rapidly during monotherapy. Ethambutol is available in capsule form, in tablet form.

Indications, contraindications:

Ethambutol appoint at all forms of of tuberculosis. The drug is contraindicated in gout , Optic neuritis, pregnancy, inflammatory diseases of the eye, cataract, hypersensitive active substance diabetic retinopathy , Breastfeeding, children up to 13 years, with chronic renal failure.

Side effects:

The sense organs, the nervous system:   hallucinations, disorientation , Weakness, dizziness, peripheral neuritis , Headaches, impaired consciousness, itching, paresis Numbness, paresthesias in extremities, scotoma, color blindness, impaired color perception, decreased visual acuity.   The digestive tract: stomachalgia , Vomiting, appetite disorders, elevation of liver enzymes, nausea. Perhaps the development of allergic reactions, anaphylaxis, arthralgia, pruritus, rash, dermatitis, fever, acute gout, of hyperuricemia .

Overdose:

Manifested by nausea, polyneuritis , Hallucinations, vomiting. Therapy posindromnaya.

Mode of application:

Ethambutol prinimabt inside. Primary treatment: 1 times a day for 15 mg / kg. Re-treatment: 2 months daily 25 kg / kg, and then move on to receive 15 mg / kg per day. Children are encouraged to take 20 mg / kg once after breakfast. The day of not more than 2 grams.

Special instructions:

In the early days of TB treatment may increase the discharge of phlegm, cough. Ethambutol administered exclusively in combination therapy with other anti-TB agents. When long-term therapy regularly monitor the work of the organs of vision, the functional state of the liver, kidneys, Peripheral Blood . Ethambutol affects the rate of reaction, control of the vehicle.

Drug Interactions:

Ethambutol increases the effectiveness of other anti-tuberculosis medications, neurotoxicity asparginazy, ciprofloxacin, lithium salts, quinine, methotrexate, imipenem, carbamazepine , Aminoglycosides.