Description overdue on 04.01.2012

The main active ingredient is metronidazole applicable. It is a derivative of 5-nitro-imidazole. Flagyl has antimicrobial, antiprotozoal activity: Giardia , Trichomonas, fuzobakterii, clostridia . Available in the form of vaginal suppositories, solution for intravenous administration in the form of tablets. Flagyl ingestion absorbed quickly and completely, binds to proteins by 10-20%, the half-life of 10 hours. Metronidazole crosses the placental barrier, breast milk, organs and tissues (bile, skin, kidneys, liver, lungs, vaginal secretions, semen, saliva , cerebrospinal fluid). 20% of the drug appears unchanged, basic metabolism occurs in the renal system.

Indications and contraindications:

Flagyl is prescribed for urogenital trichomoniasis . amebiasis , Giardiasis, nonspecific vaginitis . In severe forms of liver, intestinal amebiasis, after surgery to prevent infection drug is administered intravenously. Do not use in case of hypersensitivity to imidazoles, pregnancy, lactation.

Side effect:

Dizziness, diarrhea, headaches, vomiting, epigastric pain, anorexia, metallic taste in the mouth, nausea. Prolonged therapy can lead to Peripheral neuropathy . leukopenia . Metabolites of the drug Flagyl give urine red.

Mode of application:

Amebiasis : 7 days of therapy, a day - 1, 5 g, three doses (500 mg). Giardiasis : Therapy 5 days 750-1000mg per day. Trichomoniasis in women . vaginitis . urethritis : 10 day course of therapy at 250 mg twice a day, once or 2 grams. Suppositories are administered simultaneously.   Trichomoniasis in men, urethritis 10 days, twice a day at 250 mg once or take 2 grams. Non-specific vaginitis : Therapy 7 days, twice a day at 500 mg. Intravenous injection   are carried out only with the case of inadmissibility or inability to use tablet form of the drug Flag for 30-60 minutes administered 100 ml of the drug, which corresponds to 500 mg.

Special instructions:

Do not mix the drug allowed Fagil and disulfiram ( Esperal ), Non-depolarizing muscle relaxants action (vecuronium), indirect anticoagulants (warfarin). During treatment completely eliminated the use of alcohol-containing beverages. Preparations lithium while the use of metronidazole lead to accumulation of lithium in your body. Prolonged therapy requires monitoring of blood. With the deterioration of neurological status, expressed, frequent dizziness, ataxia Flagyl overturned. Development false positive reactions Nelson   the period of treatment is due to the immobilizing effect of the drug on Treponema.