Description overdue on 08/22/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Fleksid, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One tablet antibiotic   Fleksid depending on the form of preparation can contain 256, 23 mg. 512 or 46 mg. hemihydrate levofloxacin (active drug).

As a so-called auxiliary substances in the medicament include such compounds as: povidone, laktolozy monohydrate, sodium carboxymethyl starch, talc, glyceryl dibehenate, anhydrous silicon dioxide (colloidal)   and   Croscarmellose sodium .

Film-coating contains Fleksida   yellow and red iron oxide, titanium dioxide, and hypromellose giproloza, talc, and macrogol . The number of the above adjuvants and compounds belonging to the shell of the drug depends on the form of the drug.

Product form

Such a preparation as Fleksid produced in tablet form. A biconvex tablet antibiotic   with applied on both sides of the drug risks having an octagonal shape and wherein an orange-pink color can comprise a dosage of 250 and 500 mg. active active compound levofloxacin.

In a carton package of the drug may be placed 1, 2, 3 or 5 blisters with 5, 7 or 10 tablets containing 250 mg. drug compound, and 1, 2, 3 and 5 blisters with 5, 7, and 10 tablets of 500 mg Fleksida. each.

Pharmacological action

This medicine is distinguished by its pronounced bactericidal,   and Antimicrobial   pharmacological effects of a broad spectrum.

Pharmacodynamics and pharmacokinetics

Since levofloxacin   refers to antibacterial compounds The drug has bactericidal properties That have a wide range of applications. Fleksid blocks topoisomerase,   and DNA gyrase Thereby halting the synthesis of new harmful organisms affected DNA .

It should be particularly emphasized that the active drug compound in the vast majority of strains of harmful viruses both in vivo And   in vitro Ie both when tested in vitro and in vivo, including a human. The preparation is used for inhibiting the activity of gram-negative and gram-positive aerobic , and anaerobes .

Fleksid copes with resistant, moderately susceptible, methicillin-susceptible, penicillin-susceptible and ampicillin-sensitive As well as the so-called   hospital infections Including requiring the combined therapeutic treatment, e.g., Salmonella spp., Pseudomonas aeruginosa, Serratia spp.   and others.

During the research it was shown that due to the peculiarities of the structure levofloxacin   Use of the drug compound, together with other antimicrobials It does not provoke cross-resistance . For oral use Fleksid rapidly and almost completely absorbed in the stomach.

Its maximum concentration   (Cmax) in plasma levofloxacin It reaches after about 2 hours after direct dosing. It is also noteworthy that the meals have very little impact on the speed of the current absorption of the active drug compound of the digestive tract. The drug is rapidly distributed in the body tissues, and then metabolized   and output   through kidney .

Indications

The drug is shown for use in infectious diseases That affect:

• ENT organs , eg, sinusitis ;
• kidneys ;
• lower respiratory tract (pneumonia, bronchitis,   and others);
• urinary tract ;
• skin and soft tissues;
• abdominal cavity .

To all other levofloxacin   used in the complex therapy of severe forms TB .

Contraindications

Absolute contraindications Fleksida include:

• hypersensitivity   to quinolones , and levofloxacin ;
• shortage of the enzyme lactase Which is involved in the process hydrolysis of lactose ;
• pregnancy ;
• epilepsy ;
• hereditary lactose intolerance;
• age 18 years.

With extreme caution should be used this drug in the treatment of patients suffering from:

• diseases of the cardiovascular system;
• renal failure ;
• Diabetes ;
• lack of glucose-6-phosphate dehydrogenase;
• seizures ;
• circulatory disorders ;
• porphyria .

In addition to monitor the dosage of the drug and the schedule of its reception is elderly and patients who simultaneously Fleksidom take medications that affect the brain , eg, Ibufen   or Theophylline And drugs interacting with tubular secretion   ( Cimetidine . Probenecid   and others).

Side effects

While using the drug may experience the following side effects:

• allergic reaction,   expressed in the emergence of itching, rashes on the skin, shortness of breath, angioedema, anaphylactic shock, urticaria, pneumonitis, erythema,   and Stevens-Johnson syndrome and toxic epidermal necrolysis ;
• diarrhea ;
• nausea ;
• decreased appetite ;
• sleep disturbance ;
• vomiting ;
• colitis ;
• hypoglycemia ;
• abdominal pain ;
• enterocolitis ;
• variance ;
• dizziness ;
• tremor ;
• headache ;
• incoordination ;
• reduced vision and hearing , and   loss of charm ;
• tachycardia ;
• vascular collapse ;
• convulsions ;
• hypotension;
• arthralgia ;
• weakness in the muscles ;
• jade ;
• hypercreatininemia ;
• thrombocytopenia ;
• anemia ;
• asthenia ;
• vasculitis ;
• fever ;
• rhabdomyolysis .

Fleksid, instructions for use (method and dosage)

Dosage as a graph of its reception varies depending on the kind and severity of the disease and the patient's health. However, in accordance with instructions for use Fleksida medicine usually take 2 tablets of 250 mg. or 1 tablet in 500 mg.odin or twice a day.

In severe drug dosage can be increased to a maximum of 1000 mg. per day. For patients suffering   impaired renal function,   using individual dosing schedule which depends on the level Cl-creatine . It begins, for example, with a daily dose of 250 mg. Fleksida, then take 24 hours another 500 mg. active active drug compound and the same even after 12 hours.

It should be remembered that while the use of antacids In which structure contains Sucralfate, a salt of iron and aluminum , Fleksid should take at least two hours before or after the above indicated drugs. The duration of treatment determined by the doctor, however, continue to take the medication is for a maximum of 72 hours after the disappearance of the main symptoms of disease.

Overdose

The symptoms of overdose with this drug are:

• state of confusion ;
• convulsions ;
• nausea ;
• tremor ;
• loss of consciousness ;
• hallucinations ;
• erosion of the mucosa of the digestive tract .

To eliminate the effects of an overdose of prescribed drugs Fleksidom patients belonging to the group antacid drugs As well as adjust the dose antibiotic   or completely stop its use.

Cooperation

Current absorption of the active drug compound contained in the composition Fleksida reduce substances such as   aluminum salts, iron and magnesium. Bioavailability   the drug reduces sucralfate . In addition, levofloxacin concentration in the body is increased by 13% while receiving Fenbufen and Fleksida, which may lead to an overdose.

Fleksid influences prothrombin time Ie on blood clotting   when used in conjunction with medicinal products containing in its composition   antagonists warfarin or Vitamin K . In addition, this increases the cure rate of 33% T1 / 2 ciclosporin .

Terms of sale

Fleksid over the counter medications can be purchased by prescription.

Storage conditions

During the shelf life of the drug, it should be stored out of reach of children and monitor the temperature regime, which shall not exceed 25 ° C.

Shelf life

3 years.

Cautions

Fleksid take at least 2 hours before or after the drugs that contain in their chemical composition sucralfate, iron salts And drugs related to   antacids . With the simultaneous use of the drug and antagonists Warfarin (vitamin K) patients should be monitored parameters blood clotting .

Occasionally, however, there are cases when the treatment of the drug leads to Achilles tendon rupture   or ligaments . Usually, it is evident within the first 48 hours that have elapsed since the beginning of use of the drug. Increased risk of developing such diseases as tendinitis   It occurs when you use Fleksida elderly patients, as well as while taking corticosteroids.

If symptoms persist tendinitis   should immediately stop using the product and avoid the complications begin to treat the disease. When you see this as a side effect of the drug diarrhea , Patients should see a doctor to rule out diseases caused by harmful microorganisms species Clostridium difficile , eg, pseudomembranous colitis .

When receiving Fleksida avoid natural or artificial UV radiations. Also, you should use caution or completely abandon the activities that require high concentration of attention, such as driving.

Analogs Fleksida

The main counterparts Fleksida (500 or 250 mg.) May include the following drugs with medicines with the similarity in the chemical composition and effects on the human body:

• Glewe;
• Levofloxacin hemihydrate;
• Ivatsin;
• Lebel;
• Levofloxacin;
• A optician Rompharm;
• Levostar;
• Levofloks;
• Levotek;
• Levofloksabol;
• Levofloxacin hemihydrate;
• Leobeg;
• Lefoktsin;
• Levofloxacin STADA;
• Maklevo;
• Oftakviks;
• Signitsef;
• OD-Levoks;
• Remedy;
• Tavanic;
• Tanflomed;
• Signitsef;
• Floratsid;
• Ekolevid;
• Haylefloks;
• Elefloks.

Babies

The drug is not recommended for use during the therapeutic treatment of patients who are under 18 years of age.

With alcohol

To avoid loss of efficiency Fleksida drug when, as in the case with other drugs belonging to the Antibiotic Should avoid alcohol.

During pregnancy (and lactation)

Fleksid not recommended for use during pregnancy and during breastfeeding.

Reviews Flekside

The vast majority of patients are satisfied with the effectiveness of the drug, and therefore leave positive feedback to Fleksid (500 or 250 mg.). However, some people as a negative factor mark extensive list of side effects that may arise during the use of the drug.

Price Fleksida where to buy

The cost of medication will depend primarily on the form of the drug. For example, the average price Fleksida (500 mg., In multiples of 5 tablets) does not exceed 500 rubles.