Description overdue on 04.01.2012

Metrogil has expressed antiprotozoan (trihomonatsidnoe), antibacterial effect. Main, an active substance - metronidazole. The mechanism of drug action based on the restoration of the nitro group of metronidazole in the body of protozoa and bacteria interacting with the microbial DNA, inhibiting the synthesis of nucleic acids of microorganisms, which has a detrimental effect on bacteria and trichomonas. Metrogil regard to active Giardia . gardnerellas , Trichomonas, fuzobakterii. In combination with amoxicillin   It is used for eradication of Helicobacter pylori. Amoxicillin is able to suppress the development of resistance to the antibiotic. Metronidazole stimulates reparative processes, increases the sensitivity of tumor tissues to the action of radiation, causes disulfiramopodobnye reaction . Anti-acne drug effect appears when applied topically. Metrogil available as a vaginal gel, a solution for injection, tablet form, as a gel for topical application. Metrogil Dent addition to metronidazole contains chlorhexidine , Produced in the form of gel in plastic tubes.

Indications:

Metrogil gel : acne vulgaris , Poststeroidnye acne, rosacea . bedsores , Infections of the skin, eczema , Burns, sores, seborrheic dermatitis . oily seborrhea , Seborrheic dermatitis, trophic ulcerative lesions of the lower extremities and diabetes mellitus or Varicose Veins , Anal fissures, hemorrhoids, wounds vyalozazhivayuschie. Vaginal Gel : Nonspecific vaginitis, urogenital trichomoniasis   (vaginitis, urethritis ). Tablets injection : Treatment, prevention of infections anaerobic origins in surgical interventions on the urinary tract, abdominal, peritonitis , Sepsis, hepatic, intestinal amebiasis , Brain abscesses, abscesses of the pelvic organs, gynecological infections, osteomyelitis Infections of the joints, bones, skin, soft tissue. Metrogil prescribed as a radiosensitizing agent for tumor resistance induced by hypoxia in cancer tissue. Metrogil Dent is prescribed for diseases of the mouth of infectious genesis: gingivitis , Periodontitis, thrush , Post-extraction   alveolitis   (inflammation in the well after extraction of a tooth) cheilitis , Periodontal abscess, peritonitis.

Contraindications:

Metrogil not indicated in case of hypersensitivity to metronidazole, nitroimidazole derivatives. The drug is not indicated in pediatrics, pregnancy, severe liver pathology system to prevent accumulation of the drug, diseases of the hematopoietic system, nervous system. Do not appoint breastfeeding.

Side effect:

Nervous system : Incoordination, dizziness, depression, irritability, peripheral neuropathy . hallucinations , Seizures, insomnia, irritability, headaches, weakness in the body.   Digestive system : Loss of appetite, stomatitis, dyspepsia, pancreatitis , Glossitis, dry mouth, intestinal colic, diarrhea, metallic taste in the mouth. The urinary system : urinary incontinence . polyuria . cystitis . dysuria . candidiasis , Staining of urine red. Perhaps the development of allergy, leukopenia, neutropenia, thrombophlebitis   at the injection site, the ECG is recorded flattening of T wave

Mode of application:

Tablet form of the drug:   after ingestion, the tablet must drink milk. Trichomoniasis : The course of treatment is 10 days, twice a day at 250 mg or 5-8 days twice a day, 400 mg. Women are at the same time prescribe metronidazole in the form of vaginal suppositories. Giardiasis: treatment 5-7 days, twice daily 500 mg. Giardiazis 5 days, three times a day, a day by 15 mg / kg. Amoebiasis in the chronic form 5-10 days, three times a day at 500 mg. Amoebiasis - 2, 25 grams of metronidazole for 3 doses. Ulcerative Stomatitis : 3-5 days, twice a day at 500 mg. Pseudomembranous colitis:   3-4 times daily 500 mg. Metrogil intravenously : Duration 40 minutes infusion, the dosage of 0, 501 grams, then introduced at a rate of 5 mL / min 500 mg every 8 hours, the course of therapy - a week. The maximum permitted daily amount - 4 grams. Metrogil intravaginal : 10 days, twice a day, 250mg, should abandon the sex life during treatment of sex partners. Metrogil gel   Apply to clean skin with a thin layer twice a day, the course - 3-9 weeks. In case of necessity to enhance the effect of an occlusive dressing is applied. The course of treatment lasts up to 4 months, the therapeutic effect is noticeable after 3 weeks of therapy. Metrogil dent is applied to the area of ​​the gums twice a day.

Special instructions:

Long-term treatment requires monitoring of peripheral blood. With the deterioration of neurological status, dizziness, ataxia   treatment should be stopped. The drug Metrogil can cause false positive Nelson's reaction   due to immobilization treponem. In diseases of the liver system, prolonged vomiting, diarrhea, diseases of the digestive system drug is prescribed with caution. In combination with amoxicillin is used only for persons under age.

Drug Interactions:

Metrogil causing intolerances, like ethanol disulfiram . Increases prothrombin index It enhances efficiency anticoagulants . The recommended interval between doses of drugs Metrogil and disulfiram for at least 2 weeks. Metronidazole intravenously injected in pure form, are not allowed to mix with other drugs. Cimetidine   slows metabolic processes metronidazole. Phenytoin, Phenobarbital   stimulants and liver MAO accelerate elimination of the drug, reducing its concentration in the body. Metrogil dent increases drugs lithium in the blood can lead to intoxication. It is not allowed to mix muscle relaxants   nedopolyarizuyuschego action. Sulfonamide increase the antimicrobial action of the drug.