Description overdue on 07/31/2013

Antibiotic. The active component acts Amoxicillin   - A semi-synthetic penicillin. The drug has a bactericidal effect on bacteria, disrupting the synthesis of peptidoglycan reference polymer during its growth and division that leads to lysis of the bacterial cell. Antibiotic Ospamoks 1000 affects Salmonella, Klebsiella, esherihii coli, Neisseria on aerobic microorganisms (gram-positive and gram-negative). Strains capable of independently producing penicillinase, resistant to the antibiotic. The drug is available in granular form and in the form of a solution, and tablets. Ospamoks for children is available as a powder, which is prepared from the drop.

Indications:

The drug is indicated for the treatment of patients with bacterial infections , The source of which is sensitive to the effects of the antibiotic microorganisms. Instructions for use of the drug is recommended to appoint Ospamoks amoxicillin in abdominal infections (cholecystitis, peritonitis , Cholangitis), diseases of the genitourinary system (endometritis, gonorrhea, pyelitis, Cervicitis, urethritis, pyelonephritis, cystitis), infections of upper respiratory tract and respiratory system (acute form of otitis media, pharyngitis, sinusitis, tonsillitis, pneumonia, bronchitis), and infectious lesions of the skin, surrounding soft tissues (secondarily infected form dermatosis Impetigo, erysipelas). The drug is prescribed for sepsis, meningitis, salmonella carriers of dysentery, borreliosis, listeriosis, leptospirosis, salmonneleze   and for the prophylaxis of endocarditis.

Contraindications:

Application Ospamoksa contraindicated in polyvalent hypersensitivity against xenobiotics, intolerance to amoxicillin, penicillin, cephalosporin and carbapenem. When carrying a pregnancy, with severe renal pathology system in a variety of diseases of the digestive system (colitis on background medical therapy), breastfeeding, infectious mononucleosis   medication prescribed after consultation narrowly focused specialists with caution.

Side effect:

The digestive tract:   rarely recorded pseudomembranous enterocolitis , Glossitis, goiter, vomiting, a violation of taste perception, diarrheal syndrome, increased liver enzymes, nausea. Nervous system:   epileptic reactions, peripheral neuropathy, a form of depressive syndrome, behavioral change, anxiety, agitation, confusion, ataxia , Sleep disorders, dizziness, headaches. Application Ospamoksa 1000 may cause allergic reactions in the form of conjunctivitis, rash erythematous, exfoliative dermatitis , Eosinophilia, arthralgia, exudative erythema multiforme, fever, redness of the skin, angioedema, urticaria, rhinitis; rarely recorded anaphylactic shock. Tablets Ospamoks can cause neutropenia, anemia, thrombocytopenic purpura , Leukopenia, interstitial nephritis , Irregularities in the work and functioning of the respiratory system, vaginal candidiasis, tachycardia Forming superinfection in patients with weakened immune systems.

Overdose:

Manifest violation water and electrolyte balance , Diarrhea syndrome, vomiting, nausea. It is recommended that the appointment of laxatives, medication, maintain water and electrolyte balance, activated carbon, it is necessary gastric lavage and hemodialysis (unless contraindicated).

Mode of application:

The suspension is prepared independently Ospamoks dilution tablets in 100 ml of water; possible to prepare a syrup (dilution in 20 mL fluid). Osmapoks 500 is prescribed for adults three times a day for 0, 5 grams. In severe cases, the amount of the drug may be increased to 0, 75-1 grams (single dose). Osmapoks children appoint 0, 25 grams (for children aged 5-10 years), for 0, 125 grams (2-5 years) at 20 mg / kg (over two years) three times a day. In severe bacterial infection dose was calculated according to the scheme 1 to 60 mg per kg three times per day. In the treatment of premature infants is recommended to increase the interval between doses, or reduce the amount of antibiotics. The duration of antimicrobial therapy is about 5-12 days. For the treatment of an acute form uncomplicated gonorrhea   3 grams of amoxicillin administered once; women should receive booster dose. When infectious gynecological pathology, with the defeat of the biliary tract and the digestive tract ( typhoid fever , Paratyphoid) adults appoint Ospamoks three times a day 1, 5-2 grams, or 4 times a day for 1-1, 5 grams. Treatment of leptospirosis: within 6-12 days 4 times a day, take 0, 5-0, 75 grams of the antibiotic. At salmonellonositelstve   medicament is administered 2-4 weeks three times a day 1, 5-2 grams. For small surgical interventions for endocarditis prophylaxis before the procedure prescribed 3-4 grams of amoxicillin. Repeated reception is possible after 8-9 hours as needed. Babies Ospamoks amount of medication to be reduced by half. In the pathology of the renal system it is recommended to increase the interval between doses of the drug to 12 hours. The maximum allowable dosage for anurii - 2 grams per day. Ospamoks 250 is used for the treatment of children 5-10 years.

Special instructions:

Heading therapy requires mandatory control over the work of the renal system, of the blood and liver function. As a result, growth insensitive to the effects of amoxicillin microflora possible formation superinfection   (requires a change in circuit components and antimicrobial therapy). In patients with sepsis, in rare cases develop Jarisch-Herxheimer   Not recommended to prescribe antidiarrheal medicines, the effect of which is aimed at reducing intestinal peristalsis, in the treatment of mild diarrhea (preferred attapulgit- and koalinsoderzhaschim antidiarrheals) .  Cross forms allergic reactions to other beta-lactams are developing in individuals with hypersensitivity to penicillins . With the development of severe diarrhea should consult a physician .  Antibiotic therapy is recommended to continue for 48-72 hours after the disappearance of clinical symptoms of the underlying disease .  Women are advised to use additional methods of contraception during treatment with amoxicillin and simultaneous use of oral contraceptives containing estrogen .  Responses to the drug Ospamoks show good tolerability and high effectiveness of the drug in the treatment of bacterial infections of various etiologies .  Price depends on Ospamoks pharmacy network and varies according to region .

Drug Interactions:

Ascorbic acid is able to accelerate the absorption of the drug, the reverse effect is observed when concurrent therapy laxatives, antacid medications , Aminoglycosides, Glucosamine . Never mix amoxicillin and aminoglycosides in mind pharmaceutical incompatibility and mutual inactivation. A synergistic effect is observed in respect of bactericidal antibiotics (vancomycin, cephalosporins, aminoglycosides, rifampicin). The antagonistic effects observed with concurrent therapy bacteriostatic antibiotics (tetracycline, linkozaminy, chloramphenicol, sulfonamides, macrolides ). Amoxicillin reduces the effectiveness of oral contraceptives containing estrogen. The opposite effect is registered at reception anticoagulants   (prothrombin index decreased synthesis of vitamin K and inhibited intestinal microflora). The drug enhances the toxic effect Methotrexate Reducing its clearance. Oxyphenbutazone, allopurinol, medikamentv diuretic, nonsteroidal antiinflammatory drugs, phenylbutazone and other drugs that block tubular secretion, increase the level of concentration in the blood Ospamoksa. The drug increases the absorbability Digoxin . In the treatment increases the risk of allopurinollom skin rash .