Description overdue on 10.02.2012

Antibiotic . Resistant to penicillinase, belongs to the group semisynthetic penicillins . It is based on blocking the process of synthesizing the bacterial cells by disrupting the synthesis peptidoglycan . Oxacillin prevents the formation of peptide bonds by inhibiting transpeptidase . The drug has an effect on the lysis of bacteria dividing cells. Bactericidal effect cover Gram-positive microorganisms   (strafilokokki, korinobakterii Diphtheria Streptococci) for Gram-negative cocci   (neisserial) for actinomycetes, etc. treponemu Oxacillin no effect on fungi, protozoa, viruses, rickettsiae and some types of gram-negative flora. Resistance to antibiotics is slow. It is produced as a lyophilisate, capsules, a powder, a tablet form of 250 and 500 milligrams.

Indications:

Oxacillin is prescribed for diseases caused by infectious flora does not produce penicillinase: sinusitis, bacterial endocarditis Infected burns, osteomyelitis , Meningitis, pyelitis,   cholecystitis Sepsis, cystitis , Abscess, cellulitis .

Contraindications:

Oxacillin is not indicated in case of intolerance of beta-lactam antibiotics. In bronchial asthma, allergies, enterocolitis , Renal pathology system, breastfeeding and pregnancy used with caution.

Side effect:

Pseudomembranous enterocolitis , Allergic reactions, dyspepsia, oral candidiasis, vaginal candidiasis, eosinophilia, bronchospasm , Pyrexia, increased hepatic enzymes, proteinuria, hematuria, interstitial nephritis . Intravenous injections can develop thrombophlebitis .

Mode of application:

Oxacillin is administered intramuscularly, intravenously, taken orally. Tablets are taken one hour before meals. The maximum daily dose for adults - 3 grams. The duration of antibiotic therapy - 7-10 days, with severe disease, treatment may be extended for up to 3 weeks. Intramuscularly and intravenously administered 2-4 grams of the drug daily. Bottle 0, diluted with 25 grams of 1, 5 ml of water for injection, 0, 5 ml - 3 ml, administered intramuscularly. Intravenously: 0, 25-5 grams must be dissolved in 5 ml sodium chloride or water for injection. The course lasts 7-10days. If renal disease dosage is adjusted depending on the stage and course of the disease.

Special instructions:

Nursing and pregnant women Oxacillin appoint exceptional emergencies. If necessary, the use of antibiotics while breastfeeding switching to artificial baby foods.

Drug Interactions:

Oxacillin enhances the toxicity   Methotrexate   because of the competition for the tubular secretion. Together with the admission calcium folinate   It may need to increase the dose of antidote to folic acid antagonists, or increase the duration of therapy. Combination drug Oxacillin with benzylpenicillin or ampicillin is considered rational, expands the range of action. Do not appoint a drug possessing pronounced hepatotoxic effects . It is not permissible co-administration with bacteriostatic antibiotics. Laxatives, antacids   reduce the absorption of the antibiotic from the digestive tract. Drugs that block tubular secretion, increase the level of concentration of an antibacterial drug in the blood. Keep away from the light, it is recommended to take care of children.