Description overdue on 08.06.2012

Semisynthetic antibiotic . The mechanism of action is directed to the selective inhibition of the RNA-polymerase of microorganisms. The drug has bactericidal action   extracellular and intracellular bacteria. The antibiotic is active against Mycobacterium tuberculosis, Gram-positive microorganisms. Fast resistance to the drug develops at monotherapy. Rifabutin is available in capsule form.

Indications, contraindications:

Rifabutin is used in pulmonary tuberculosis. The drug is prescribed at infectious lesions of, caused by mycobacteria. Rifabutin is not applied when breastfeeding, of intolerance to of the basic substance, when carrying of a pregnancy. In severe kidney disease, or liver of an antibiotic is prescribed with caution.

Side effects, overdose:

Dysgeusia, nausea, vomiting, jaundice, increased transaminase enzymes, anemia, myalgia, thrombocytopenia , Leukopenia, myalgia, allergic reactions, uveitis, anaphylactic shock, bronchospasm, eosinophilia, fever. In overdose recorded increased severity of these side effects. Requires gastric lavage, diuretics, posindromnaya therapy.

Mode of application:

Rifabutin is prescribed inside 1 time per day. Immunosuppressed patients for the prevention of infectious lesions is shown receiving 300 mg per day. Nontuberculous mycobacterial infections When Rifabutin is used in combination with other drugs to six months of 450-600 mg per day (after receiving negative seeding). In chronic course of multidrug-resistant pulmonary tuberculosis antibiotic is prescribed to 6 months (from the date of receipt of the negative crop) of 300-450 mg per day. When newly diagnosed pulmonary tuberculosis is shown receiving 150-300 mg per day. In moderate pathology of the kidney and liver adjustment of the dosing regimen is required.

Special instructions:

Antibiotic therapy is required for regular blood tests to leykoformuly assessment, determine the level of liver enzymes. The risk of developing uveitis   greatly increased, while taking clarithromycin or by applying the drug in large quantities. With the development of uveitis Rifabutin canceled ophthalmologist should be consulted. During the period of medication possible staining of biological fluids into a reddish hue. Contact lenses can also be colored in orange. When monotherapy significantly increases the probability of the formation of microbial resistance. It is recommended to appoint kombinirovannub therapy with other anti-tuberculosis drugs Who do not belong to the group of rifamycins. During the period of antibiotic therapy oral contraceptives   inefficient, require the use of barrier contraception .

Drug Interactions:

Rifabutin accelerates metabolism of drugs in the hepatic system. Antibiotic reduces concentration zidovudine   in blood. Development of the clinically significant interactions with pyrazinamide, sulfonamides, theophylline, ethambutol, zalcitabine, with fluconazole it is unlikely. Clarithromycin and fluconazole can raise the concentration of antibiotic in blood.