Description overdue on 02.03.2012

Natural antibiotic . The active component is spiramycin . At the bacteria has drug bacteriostatic effects . With regard to highly sensitive strains of high-dose macrolide antibiotic Rovamycinum may have a bactericidal effect. The active substance by the reversible binding reaction with the 50S ribosomal subunit to inhibit protein synthesizing a microbial cell, resulting in blocked translocation transpeptidation. Rovamycinum associated with up to three domains of subunits, which allows for a more stable binding to the ribosome and get long antibacterial effect . High concentrations of spiramycin may accumulate in the bacterial cell. Rovamycinum has no stimulating effect on intestinal motility, unlike erythromycin. The drug effectively used for the treatment of congenital toxoplasmosis and toxoplasmosis during pregnancy. Rovamycinum reduces the risk of transmission of infection from a pregnant woman's unborn child. Infected fruit preparation has no effect on the severity of the disease. Joined cross-resistance between antimicrobials: erythromycin   and spiromitsin. Rovamycinum available as a lyophilizate tablets.

Indications:

Rovamycinum prescribed for toxoplasmosis pregnant , Bacterial infections: acute bronchitis, acute form pnebolnichnoy pneumonia, arthritis, osteomyelitis . otitis . tonsillitis . sinusitis . prostatitis . extragenital clamidiosis . gonorrhea . The drug is effective in the abscess, dermatosis , Erysipelas, phlegmon, toxoplasmosis. The drug is used as a form of prevention of acute articular rheumatism , Meningococcal meningitis . Spiramycin is prescribed for Diphtheria   and whooping cough   for the treatment of bacteria.

Contraindications:

Rovamycinum not prescribe intolerance spiramycin, breastfeeding. The drug is not used in pediatric practice, pathology and obstruction of the biliary tract, liver failure system.

Side effect:

Increased activity of the enzymes alanine aminotransferase and alkaline phosphatase, diarrhea, vomiting, nausea, allergic reactions. Rarely recorded cholestatic hepatitis , Thrombocytopenia, ulcerative esophagitis, acute colitis The injury of the intestinal wall.

Mode of application:

Rovamycinum taken orally, injected intravenously. Adults: 1, 5-3 million. IU three times a day or twice a day by 306 million. IU. In severe bacterial infections of the antibiotic dose was increased to 7, 5 million. IU twice daily. Rovamycinum administered intravenously infusion over one hour: 4 milliliters fody dissolve the contents of one vial and then added 100ml of dextrose (5% solution). When pneumonia spiramycin administered every eight hours for 1, 5 million. IU. In severe disease dosage is doubled.

Special instructions:

Correction mode is not required, even in severe renal pathology system. For the period of application of antibiotic Rovamycinum breastfeeding is stopped (the active ingredient can penetrate into the milk, affect the health of the baby). Spiramycin has no teratogenic effects , It can be used during pregnancy. In the pathology of hepatic system Regular monitoring of liver function.

Drug Interactions:

Rovamycinum prescribed with caution with medications that contain ergot alkaloids dehydrated form. Medicinal products with a combination of carbidopa and levodopa at the same time taking Rovamycinum to increase the period of its half-life, which is explained by the absorption of carbidopa antibiotic suppression due to changes in intestinal motility. Rovamycinum not interact with theophylline   and cyclosporine   Unlike related macrolide erythromycin.