Description overdue on 26.05.2012

Antibiotic, aminoglycoside . The active substance is formed by vital ray fungi species Streptomyces globisporus, which are used in industrial production. Streptomycin penetrates microbial cell, binds and interacts with specific proteins, which leads to disruption of the formation of a messenger RNA and the disintegration polyribosomes. Such feedback mechanism leads to the formation of defects when reading DNA , Stopping the growth and development of bacteria. Streptomycin acts bacteriostatic. Aminoglycoside easily destroyed by heating in a solution of strong alkalis and acids, with the streptomycin resistant under mildly acidic conditions. Streptomycin is available as a powder for solution.

Indications:

Streptomycin is prescribed for venereal granuloma , Tuberculous meningitis, tuberculosis of different localization, urinary tract infections, intestinal infections, endocarditis   (combination therapy with ampicillin), plague, brucellosis , Tularemia.

Contraindications:

Streptomycin is not indicated during pregnancy, severe renal disease with severe uremia, azotemia, intolerance aminoglycosides, defeat 8 pairs of cranial nerves organic nature. At occlusive disease , Botulism, Parkinson's disease, myasthenia gravis, breastfeeding, tendency to bleeding, children and the elderly, in the pathology of cerebral circulation Sterptomitsin used with caution.

Side effect:

The digestive tract:   irregularities in the system of liver, diarrhea, vomiting, nausea, increase in liver enzymes. Nervous system:   weakness, drowsiness, headaches, neuritis of the facial nerve , Peripheral neuritis, neurotoxic effects in the form of seizures, paresthesias and muscle twitching, night apnea , Shortness of breath, respiratory arrest. Senses:   hearing loss, buzzing in the ears and nasal, ototoxicity , Labyrinth disorders in the form of instability, incoordination, nausea and vomiting, vestibular disorders. Urinary system:   oliguria, change in frequency of urination, nephrotoxicity , Vomiting, nausea, eating disorders, thirst , Polyuria. Possible fever angioedema , Rash, flushing of the skin, itching, redness at the injection site.

Overdose:

It manifested in the form of toxic reactions ataxia , Hearing loss, thirst, vomiting, nausea, urinary disorders, respiratory disorders, stuffiness in the ears, tinnitus, vertigo. Therapy is aimed at lifting the blockade of neuromuscular transmission, peritoneal dialysis and hemodialysis, the introduction of calcium salts, anticholinesterase medicines, ventilator.

Mode of application:

Streptomycin administered as aerosols intrabronhialno intratracheally, intramuscularly, orally (in treatment of infections of the digestive tract). Intramuscular administration of a single dose for adults is 0, 5-1 grams per day of not more than 2 grams. Streptomycin intratracheally administered at 0, 5-1 gram 2-3 times a week. When comorbidity as CHD, hypertension drug in the initial dosage of 250 mg per day in the case of registration of a good endurance dose increase. In the pathology of renal dosing system is made depending on the severity of the disease.

Special instructions:

The risk of nephrotoxicity increases significantly in patients with pathology of the renal system, as well as long-term administration of the drug Streptomycin high dosages that requires control of the parameters of the kidneys. During the period of medication needed control over the functioning of the vestibular apparatus, the auditory nerve, kidney. When you register unsatisfactory results of audiometric tests streptomycin dosage reduced by half or stop therapy. In the absence of positive dynamics of the physician is to raise the question about the change of the antibacterial agent in mind the possible development of microbial resistance. A small amount of aminoglycoside is able to penetrate through breast milk due to their poor absorption from the digestive tract. However, no serious complications were reported.

Drug Interactions:

Streptomycin is incompatible with ototoxic drugs nephrotoxic drugs, polymyxin, an aminoglycoside. In an application with methoxyflurane significantly increases the likelihood of side effects of both drugs. Intravenous infusion of indomethacin a decline renal clearance   drug increases its half-life period, increasing the concentration of streptomycin. The drug has a negative impact on the effectiveness of medicines antimiastenicheskih. Halogenated hydrocarbons and other inhalants for general anesthesia, as well as narcotic analgesics and transfusion of large volumes of blood containing citrate preservatives increase neuromuscular blockade.