Description overdue on 05/29/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications sulfadimetoksin
• Contraindications
• Side effects
• Instructions for use sulfadimetoksin (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

In terms of mass fractions of solids, one tablet contains 500 grams main biologically active component. Additionally, the present composition:

• potato starch ;
• povidone   (full name - a low molecular weight polyvinyl medical);
• anhydrous silica   (colloidal);
• calcium stearate .

Product form

The drug is available in two variations:

• Powder   (single dose contains 0.2 grams of basic component).
• Pelleted Sulfadimetoksin   - 10 tablets in contour cell package (in the box - 10 mesh plates).

Pharmacological action

Sulfadimetoksin as a typical representative of sulfa drugs, has a bacteriostatic effect on pathological microorganisms. The mechanism of action opens organic chemistry, the main component of the biological medicinal product is a structural analogue   para-acid aminbenzoynoy That it competitively inhibits during formation folic acid   (a key factor in the growth and development of the majority of microorganisms).

Thus, it inhibits the synthesis of nucleic acids (such as purine and pyrimidine bases is necessary for the existence of dihydrofolate ), Which manifests itself in the inhibition of growth and reproduction of foreign, microscopic organisms. Human cells only consumes and utilizes metabolite Vitamin B9 Because of its ability to live a drug is not threatened.

Sulfadimethoxine is active against a large number of Gram-positive and Gram-negative microorganisms. Thus, the drug is excellent fights pneumococci , Different types of streptococci and staphylococci . shigella dysentery . E. coli   and pneumobaccillus   ( Klebsiella ). Slightly worse noticeable effect on Trachoma   and Proteus .

Pharmacodynamics and pharmacokinetics

The half-life of the drug is 24-48 hours depending on the individual. Sulfadimetoksin well absorbed mucosa of the gastrointestinal tract. The systemic circulation is bound to plasma proteins, and then uniformly distributed to all tissues and organs. The medicament can penetrate through blood-brain barrier   and placenta . A favorite place of accumulation are serous cavities of the body .

The drug is metabolized in the liver by acetylation. Solubility products after chemical transformation deteriorates significantly, depending on the acidity of the primary urine. Sulfadimetoksin Provided mainly kidneys, can sometimes lead to the formation of crystals ( crystalluria ).

Indications sulfadimetoksin

Here is a small list of what Sulfadimetoksin effectively helps in a relatively short period of time:

• pneumonia ;
• acute respiratory infections   Upper respiratory tract;
• bronchitis   with confirmed bacterial etiology;
• shigellosis dysentery ;
• sinusitis ;
• tonsillitis ;
• inflammation of the central nervous system ( meningococcal infection );
• Pathology of the urinary and urinary systems with positive cocci agent.

Sulfadimetoksin can be used in the treatment when conservative treatment scheme included several drugs of different directions for a more complete spectrum of therapeutic action. In this case, the indications for use are expanded by the following diseases:

• resistant form malaria ;
• wound infection ;
• pyoderma   - Purulent inflammation of the integument due coccal invasion;
• mug   (or erysipelas ) - An infectious disease with a characteristic erythema and bullae on the upper and lower extremities.

Contraindications

From reception sulfadimetoksin should be discarded if there is hypersensitivity or intolerance of separate components of the drug, a hereditary or acquired deficiency glucose 6-dehydrogenase . azotemia   various etiologies.

Under the close supervision of qualified medical personnel should use the drug, if present in the history of s abolevaniya hematopoietic system   or decompensated form Heart Failure .

Side effects

Conservative treatment is generally well tolerated, if the treatment is carried out in a hospital. Otherwise, possible adverse reactions such as:

• Headache   and dizziness .
• Dyspeptic digestive disorders   (dryness in the mouth, nausea, vomiting, diarrhea ).
• Drug fever   - A sharp rise in the temperature curve immediately after taking the drug.
• The skin, itchy rashes.
• Leukopenia   - Reduce the level of free leukocytes in the systemic circulation, and as a consequence decrease resistance.
• Cholestatic hepatitis   - An inflammatory disease of the liver with the stagnation of bile in the excretory ducts.
• Allergic reactions   - hives . dermatitis . angioedema   or another.

Separately, it is worth noting that Sulfadimetoksin specific forms crystals in the urine, causing pills alter the color saturation tan at a certain acidity, due to the formation of specific crystals.

Instructions for use sulfadimetoksin (method and dosage)

First of all, we should conduct a test on the sensitivity of pathogens cause disease, because not all strains coccal infections   respond to treatment sulfanilamide preparations.

Tablets to be taken orally with an interval of 24 hours. The course of treatment is from 7 to 14 days, depending on the pathophysiology of the disease. How to take the tablets in each case the physician will prescribe, but a general scheme for adults - c 2 on the first day of hospitalization, and 1 c to maintain a stable level of active component in the systemic circulation.

Instructions on Sulfadimetoksin slightly different pediatric . On the first day administered 25 mg / kg, and further by 12.5 mg / kg in the early childhood. If the child is older than 12 years, the initial dose of 1 g, and support - 0.5 c.

Overdose

Saturation condition of the body preparation is clinically manifested in intense thirst And strong dry mouth , A small amount of saturated yellow-brown urine , Pain in the right upper quadrant (liver projection) and lower back (kidney localization). Biochemical analysis revealed a significant increase in enzymes such as AST . ALT and acid phosphatase .

Therapeutic measures in overdose:

• Reflex initiation vomiting.
• Gastric lavage or high enema.
• Cementing and adsorbing drugs orally.
• Saline laxatives.
• Forced diuresis If the drug had time to fully be absorbed from the gastrointestinal tract.

Cooperation

Sulfadimetoksin not be combined with:

• The drug inhibits blood (for example, butadionom   or analginum ).
• Oral sugar-lowering drugs (derivatives sulfonylureas ).
• Derivatives of p-amino benzoic acid (local anesthetics group novocaine ).

Action pharmacological agents will increase if the main component in addition to the therapeutic course apply:

• nonsteroidal antiinflammatory drugs;
• antithrombotic drugs;
• barbiturates;
• antagonists Vitamin K .

Effects sulfadimetoksin falling on the background of Use folic acid , Oral contraceptives and bactericidal beta-lactam antibiotics ( penicillins . carbapenems . cephalosporins   and so on).

The toxicity of the drug increases:

• derivatives pyrazolone ;
• salicylates ;
• Methotrexate   and difenin .

Terms of sale

Sulfadimetoksin released only at the doctor's receptor Form, since the pharmaceutical drug has been on the list of B (potent substances).

Storage conditions

Saves tablets should be in a dry place inaccessible to children at temperature not exceeding 25 degrees Celsius. Be sure to monitor the availability of the original packaging of tablets.

Shelf life

The minimum shelf life of the product - 5 years.

Analogs sulfadimetoksina

Sulfamonometoksina . Sulfametoksipirazin ( Sulfalen ) Sulfadiazine ( Sulfazin ) Sulfamethoxazole .

Synonyms

Madribon   (the most common, as it is the brand name sulfadimetoksin) Madroksin . Duposul . Fuksal . Supersulfa .

Babies

The drug is given only three years.

During pregnancy and lactation

Sulfadimetoksin strictly contraindicated in pregnancy , At maturity or milk breast-feeding .

Reviews sulfadimetoksin

Doctors' opinions about the effectiveness of the drug confirmed the drug in the fight against coccal infection   internal organs and skin, if fully comply with conservative treatment. Otherwise pathogens develop resistance to the entire group of products, since all sulfonamides   It has a typical chemical structure.

The surgical hospitals give a good estimate of the complex preparation ( dioksometiltetragidropirimidin   + sulfadimetoksin   + trimekain + chloramphenicol ), Since in this composition the main effect of the biologically active substance is complemented analgesic, anti-inflammatory action and necrolytic. The drug is the drug of choice in the sanation scheme a large number of purulent disease entities.

We should also note that the forum is common question is: " Sulfadimetoksin - an antibiotic or not? ". This misconception dispelled Dr. Komorowski on his official website: " Preparation destructive effect on pathogens, respectively, on the basis of the pharmacological definition of antibiotic - is such Sulfadimetoksin ".

Price sulfadimetoksin

The cost of the drug in the pharmacy in Ukraine leaves 5 hryvnia. The price in the Russian Federation is somewhat different and is about 25 rubles.