Description overdue on 15.01.2012

Trichopolum refers to the group of antimicrobials and antiparasitic drugs, the active ingredient is metronidazole. Getting into bacteria and protozoa drug alters its chemical structure, and then reacted with the microorganism and disrupts DNA synthesis. Inhibition DNA Replication   It leads to cell death. Trichopolum effective against protozoa, anaerobic bacteria, Gram-positive and Gram-negative number of organisms ( Giardia , Balantidiums, gardenelly,   Trichomonas . clostridia , Fuzobakterii, Bacteroides, peptokokki et al.). The human body is relatively evenly distributed Trichopolum: high concentrations of the drug are recorded in the cerebrospinal fluid and semen, vaginal secretions. Across blood-brain barrier   passes and into brain tissue. When you receive a tablet form of the drug Trichopolum limiting content in the blood plasma is fixed in half an hour, however, it should be noted that taking metronidazole along with food will slow the absorption of the drug. It is metabolized in the liver, respectively, the pathology of the body, accompanied by a lack of function, slows metabolism. The resulting derivatives of metronidazole also have antimicrobial activity. The kidneys are responsible for removing Trichopolum from the body (75-85%), due to which, during the course of therapy may discoloration of urine Until brown.

Indications:

Trichopolum effective in protozoal infections ( trichomoniasis . amebiasis , Giardiasis, balantidioza , Leishmaniasis, etc.), among these diseases account for a significant portion of urogenital infections, in particular Trichomonas urethritis   and Trichomonas vaginitis. A significant proportion of infections that are sensitive to the drug, it is necessary for bacterial destruction of bones, joints, heart muscle and the brain ( meningitis   or abscess of the brain, the heart - bacterial endocarditis Light - pneumonia , Lung abscess), as well as infectious inflammatory pelvic (ovarian abscess, endometritis Inflammation of the fallopian tubes). Indications Trichopolum complements peptic ulcer . Trichopolum detrimental effect on Helicobacter pylori, which plays a key role in the etiology and pathogenesis of the disease. In surgery the drug is used as a preventive measure to avoid complications after surgery.

Contraindications:

Do not appoint Trichopolum children up to six years, pregnant women (in the first trimester is absolutely contraindicated after the 12th week - with extreme care), nursing mothers. Contraindicated in disorders of the nervous system of an organic nature, epilepsy , Severe hepatic and renal. Also it is necessary to refrain from taking the medication with a history of allergic reactions and leukopenia .

Side effect:

Digestive system : Indigestion, taste, in extreme cases, may develop toxic hepatitis,   pancreatitis . Nervous system : Blurred vision, headaches, ataxia , Incoordination and dizziness. Hematopoietic system : Reduction in the number of platelets and erythrocytes, agranulocytosis . Among other side effects it is necessary to mention allergic reactions (redness of the skin and cold to anaphylactic shock).

Mode of application:

Trichopolum available as suspensions and tablets for oral administration, a vaginal tablet, powder for intravenous administration, the solution for infusion therapy. For treatment trichomonas infection   (pay attention to the fact that the treatment of genital lesions should undergo both partners) appointed interior in a dosage of 250 g twice daily after meals. In addition, once a day should be administered in the vagina vaginal form Trichopolum. The course of treatment - 10 days. Treatment of men has no fundamental differences, in any case, the dose and dosing frequency should be regulated by the attending physician. Interesting use of the drug is peptic ulcer   - In this case Trichopolum administered usually in a daily dose of half gram (two doses after meals). When treating bacterial vaginosis   the dose was increased to a gram, while for therapy anaerobic infections   Dosage can reach one and a half grams. Particular attention should be paid to the treatment of patients with impaired renal parenchyma - in this case, the dosage is reduced three times. Trichopolum parenterally administered in a dose of 1 g, the infusion is carried out for half an hour. The maximum daily dose - four grams. For the treatment of children under 12 use the following formula for calculating the dose: 7, 5 mg per kilogram of body weight.

Special instructions:

During the course of therapy should refrain from even minimal alcohol consumption. In the treatment of trichomonas infection genitals should stop sex life during treatment, therapy during menstruation ceases. The emergence of severe neurological symptoms in patients receiving the drug is an indication for its cancellation. In the event of pathological changes in the blood is necessary to reconsider the usefulness of Trichopolum (take into account the risk of infection and the risk of complications). If you want to assign the drug during breast-feeding should be discontinued at the last period of treatment.

Drug Interactions:

Children are not encouraged to nominate at the same time amoxicillin . Due to the influence on the blood-forming organs, Trichopolum potentiates the action anticoagulants . It contributes to the accumulation of lithium in the tissues, and when taken with medications containing lithium may develop toxicity. Cimetidine   zamelyaet metronidazole metabolism and contribute to its accumulation in the body. Sulfonamide increase antibacterial effect Trichopolum. Trichopolum Phenobarbital accelerates the conversion in the liver.