Description overdue on 05/14/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use vilprafen (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• With alcohol
• With antibiotics
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Vilprafen following composition:

• one tablet   contained 500 mg josamycin ;
• suspension   (10 ml) contains 300 mg of the composition josamycin .

Furthermore, auxiliaries Vilprafen comprises: microcrystalline cellulose . methyl cellulose . polysorbate 80 . silica colloidal anhydrous . sodium carboxymethylcellulose . magnesium stearate . talc . titanium dioxide (E171) . Macrogol 6000 . poly (etakrilatmetilmetakrilat) -30% . aluminum hydroxide .

Product form

Produced product in the form of coated tablets. In blisters contains 10 such tablets. Packaging is embedded in a cardboard box. How many pills in the package, and as in the packet.

Also, the drug is released in the form of a suspension. Contained in dark glass bottles, 100-ml vial. Includes measuring cup. The suspension of flakonchike contained in a cardboard box.

Also produced candles with the active substance.

Pharmacological action

The tool is antibiotic Which belongs to the group of macrolides. On the body has a bacteriostatic effect which is produced by inhibiting bacterial protein synthesis. If the outbreak of inflammation there is a high concentration of the drug, it has a strong bactericidal effect.

The high activity of the active substance is marked with respect to a number of intracellular bacteria: Chlamydia pneumonuae . Chlamydia trachomatis . Mycoplasma hominis . Mycoplasma pneumoniae . Legionella pneumophila . Ureaplasma urealyticum . Also, the drug acts on gram-positive aerobic bacteria: Streptococcus pyogene s . Staphylococcus aureus . Corynebacterium diphtheriae . Streptococcus pneumoniae (pneumococcus) . Marked effect on gram-negative aerobic bacteria Haemophilus influenzae . Neisseria gonorrhoeae . Bordetella pertussis . Neisseria meningitidis And some anaerobic bacteria Peptostreptococcus . Clostridium perfringens . Peptococcus .

There vilprafen activity in relation to the   Treponema pallidum .

Pharmacodynamics and pharmacokinetics

Following oral administration says fast absorption material from the gastrointestinal tract. The highest concentration of funds is achieved within 1-2 hours after ingestion. After 45 minutes after administration of agent in the dose of 1 g on average josamycin concentration in plasma is 2.41 mg / L.

The active substance is bound to the blood protein is not more than 15%. If the drug is taken with an interval of 12 hours, the tissues retained sufficient concentration of josamycin during the day. After 2-4 days equilibrium is reached its contents.

Josamycin able to easily penetrate through the membrane. It accumulates in lymphatic, pulmonary tissue, tonsils, in the urinary organs, as well as soft tissues.

The highest concentration of the drug is observed in the tonsils, saliva, lungs, sweat, tear fluid.

In hepatic biotransformation occurs josamycin, so that it becomes less active metabolites.

Because the body is mainly excreted in the bile, urine is allocated less than 20% of the substance.

Indications

Before you start treatment, be sure to consult with your doctor and read the summary, which describes, from which tablets.

Indications are as follows:

• Infectious diseases that trigger inflammatory processes, which were caused by microorganisms with a high sensitivity to the drug.
• Infectious diseases of upper respiratory tract and upper respiratory tract (used in sore throat . pharyngitis . tonsillitis . sinusitis . laryngitis . otitis media ).
• Infections of the lower respiratory tract (in pneumonia . acute bronchitis . whooping cough . bronchopneumonia ).
• Infections of the oral cavity (in diseases periodontal . gingivitis ).
• Infections of skin and soft tissue (with boils . pyoderma . lymphadenitis   and etc.)
• Infections of the urinary organs (when chlamydia At ureaplasma . gonorrhea . urethritis . prostatitis   and etc.)
• It is used in the treatment of diphtheria in addition to therapy with diphtheria antitoxin.
• People with hypersensitivity to penicillin is indicated for scarlet fever .

Contraindications

We can not accept funds in the following cases:

• in case of hypersensitivity to antibiotics macrolides ;
• in severe violations of liver function.

Side effects

Notes the following side effects of this agent in the treatment of:

• The functions of the digestive system: rarely observed symptoms of nausea, Heartburn , Vomiting, diarrhea . In severe persistent diarrhea may develop severe pseudomembranous colitis due to the effect of antibiotics on the body.
• Rarely develop hypersensitivity reactions: rarely observed allergic reactions on the skin.
• The functions of the liver and biliary tract: sometimes marked transient increase in liver enzymes in the blood plasma, which can be accompanied by a violation of the outflow of bile, followed by jaundice .
• Rarely observed dose-related hearing loss.

Instructions for use vilprafen (method and dosage)

Antibiotics taken in the following manner. Adults and adolescents who are over 14 years old, take 1-2 grams of the drug in two or three doses. Starting with the recommended dose of 1 g

In the treatment of chlamydia should take 500 mg twice a day for 12-14 days. Treatment for rosacea includes receiving 1000 mg of drug which should be divided into two doses per day. Treatment lasts 10 days.

The dosage, which should be used pills   in a number of other diseases, defines only the attending physician taking into account the individual characteristics of the disease. But in the main course of treatment lasts at least 10 days.

Instructions on Vilprafen Soljutab   provided that the drug may be administered in various ways: it is possible to take a pill, washed down with water or before dissolved in 20 ml of water. The suspension, which was formed after the dissolution of the tablet, you need to very thoroughly.

Tablets Vilprafen   It should be swallowed whole. Patients often wonder how to take before or after a meal. The manual states that the tablets should be swallowed between meals.

Overdose

To date, no data on overdose symptoms of poisoning and drug. If an overdose may cause those characteristics which are described as the side effects of the drug.

Cooperation

Speaking of the interaction with other drugs, it should be noted that Vilprafen - an antibiotic. Before using any medication, be sure to determine the antibiotic is, or not.

If Vilprafen appointed concurrently with antihistamines, which contain terfenadine   or astemizole Sometimes it slows down the process of removing these substances, which ultimately leads to the expression of the heart arrhythmias Life-threatening.

When concomitant administration with vilprafen ergot alkaloids   It can be enhanced vasoconstriction. Therefore, in this case, need careful monitoring over the condition of the patient.

Simultaneous reception and josamycin cyclosporine   provokes rise in the level of cyclosporine in the blood plasma. Also noted in the blood concentration of cyclosporine nephrotoxicity. If such treatment is necessary to ensure continuous monitoring of the plasma concentrations of cyclosporine.

If both accept and Vilprafen Digoxin May povyshatya digoxin level in blood plasma.

When you receive a vilprafen hormonal contraceptives   may reduce the effect of the latter. In this situation, we recommend the use of additional non-hormonal contraceptives.

Terms of sale

It sold only by prescription.

Storage conditions

It refers to the list B. Store the drug in a dark place at a temperature not exceeding 25 ° C. The drug should be protected from children.

Shelf life

Vilprafen can be stored for 4 years.

Cautions

People suffering renal failure You need to take into account the treatment of the results of laboratory tests.

It is necessary to consider the possibility of resistance to various antibiotics macrolides.

Analogs

Analogs vilprafen 500 mg, having the same active ingredient, pharmacies are not implemented. What can replace this drug should be determined only by the doctor. Substitute selected taking into account the individual characteristics of the disease.

The analogs are considered drug preparations which belong to the group of macrolides. This group includes erythromycin . clarithromycin . azithromycin . roxithromycin . spiramycin . Price analogues may be either higher or lower than the cost vilprafen. Analogs Vilprafen Soljutab similar.

Patients often wonder what Vilprafen   differs from Vilprafen Soljutab . What is the difference of these drugs due to their form of release. Vilprafen - a conventional tablets, film-coated. Vilprafen Soljutab - is soluble tablets, which have a sweet taste and fruity aroma. They can be administered in tablet form and in suspension.

Synonyms

Josamycin .

Babies

Vilprafen children under the age of 14 years is used as a suspension. Vilprafen Soljutab 1000 mg can be dissolved in water to prepare a slurry. If drug treatment administered to children, the dosage is as follows: 30-50 mg per 1 kg of body weight divided into three stages. Suspension for children under the age of three months, respectively, dispensed with the exact weight of the child. Why tablets are used, and whether they should be used for treatment, the doctor should be consulted.

With alcohol

If the combined alcohol and Vilprafen, then as a consequence a person may experience a variety of disorders in the digestive system. Alcohol and antibiotics when combined can provoke the manifestation of the effect of hepatotoxicity. Furthermore, such a combination can be a triggering factor for the development of cirrhosis. Even one-time it is not necessary to combine Vilprafen and alcohol, as when used with alcohol responses indicate that the well-being may be affected.

With antibiotics

It should appoint Josamycin simultaneously with bacteriostatic antibiotics because it can decrease their bactericidal effect.

It is impossible to reconcile with Vilprafen Lincomycin Since it reduced the effectiveness of the two drugs.

During pregnancy and lactation

Vilprafen 500 mg Vilprafen Soljutab during pregnancy and lactation may be imposed after the doctor carefully evaluates the risks and benefits of such treatment. Doctor weighs, what the consequences are possible after application of the drug, and only then prescribe a course of treatment. During pregnancy Vilprafen can be used to treat chlamydia. However, if in the course of this treatment side effects observed during pregnancy, which says the guide, it is necessary to discontinue treatment. Assessing vilprafen intake during pregnancy, expectant mothers leave the reviews range from the positive to those where it comes to the appearance of side effects.

Reviews Vilprafene

Reviews about the drug and its effects on the body of evidence that the drug has an effective impact, but sometimes marked manifestation of side effects. Reviews for chlamydia, as well as in the treatment of ureplazmu say that the symptoms disappear after a few days. As the side effects mentioned digestive disorders, allergic skin reactions.

There are positive comments on Vilprofen Soljutab in the sinus and other infectious diseases. For children prescribers often, its effectiveness is confirmed by the experience. Sometimes in a review, sometimes it is that after a course of treatment with this medicine, the child develops dysbiosis .

Price vilprafen where to buy

Pills   It can be purchased at any pharmacy on prescription. Price Vilprafen 500 mg on average 560-620 rubles. Antibiotic in Ukraine can be bought for the price of 300 USD. Vilprafen cost can vary depending on the location of sales. How much is 500 mg Vilprofen in Donetsk or in any other city, can be found on the websites of online pharmacies.

Cost Vilprafen Soljutab   1000 mg on average 640-680 rubles. The price of the drug in Ukraine (Kharkiv and other cities) is from 260 UAH. 10 tablets.