Description overdue on 31.10.2011

Combined antimicrobial drug. Main, an active substance - co-trimoxazole   (trimethoprim + sulfamethoxazole). Biseptolum has a double locking effect on bacterial metabolism. Trimethoprim   It has an inhibitory effect on an enzyme involved in the metabolism of folic acid, and converts dihydrofolate into tetragidroflorat. Sulfamethoxazole   bacteriostatic effect. In the complex components of the drug Biseptolum block purine biosynthesis and nucleic acids, which are essential for the reproduction and growth of bacteria.
Produced in tablet form, as a suspension, syrup, solution for infusion. Biseptolum children is available as tablets, suspension of 120 mg (for children from 3 months.).

Indications:

Biseptolum prescribed for infection of the urinary tract: pyelitis, urethritis . prostatitis . pyelonephritis . gonorrhea , Epididymitis, lymphogranuloma venereum, chancroid, granuloma inguinale.
Gastrointestinal infections:   paratyphoid , Cholera, typhoid fever , Cholangitis, dysentery . gastroenteritis   (E. coli), cholangitis, salmonellonositelstvo. Respiratory tract infections: lobar pneumonia, bronchiectasis, bronchitis   (acute and chronic), PCP, bronchopneumonia . Infections of the upper respiratory tract: sore throat . sinusitis . otitis media .   scarlet fever . laryngitis . Soft tissue infections, skin: abrasions, acne , Wound infections, pyoderma . In the treatment used to treat toxoplasmosis, malaria, South American blastomycosis, acute brucellosis.

Contraindications:

Aplastic anemia, leukopenia, pregnancy, agranulocytosis, B12 deficiency anemia, severe disorders in the renal / hepatic systems hyperbilirubinemia   children. Precautions Biseptolum prescribed for asthma, lack of folic acid, thyroid disease.

Side effect:

Nervous system : Dizziness, headache, depression, rarely, aseptic meningitis , Tremor, apathy , Peripheral neuritis. Respiratory system : Pulmonary infiltrates, bronchospasm.   Digestive system : Dyspepsia, cholestasis, diarrhea, vomiting, anorexia, glossitis, epigastric pain, gastritis, increased liver transaminases, stomatitis, pseudomembranous enterocolitis, gepatonekroz hepatitis. Forming Organs : Megaloblastic anemia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia. The urinary system : Crystalluria, interstitial nephritis, polyuria, toxic nephropathy anuriei , Oliguria, increased levels of urea, haematuria, renal failure. Locomotor apparatus : Myalgia, arthralgia. thrombophlebitis , Hypoglycemia, allergy .

Mode of application:

Adults 960 mg dose, or 480 mg to 2 doses. Severe infections: 480 mg three times.
Chronic infections: 480 mg twice. Babies Biseptolum administered twice daily dose of 120 to 480 mg. In acute brucellosis   Course of treatment is 3-4 weeks, paratyphoid and typhoid fever - up to 3 months.

Overdose:

Intestinal colic, dyspepsia, headache, dizziness, drowsiness, vomiting, confusion, fever, depression, hematuria , Fainting, blurred vision, leukopenia, fever, crystalluria . During prolonged overdose marked jaundice, megaloblastic anemia, thrombocytopenia, leukopenia. You must enter trimethoprim, calcium folinate intramuscularly at a dose of 5-15 mg / day. As necessary, designate hemodialysis. No specific antidote.

Special instructions:

Requires regular monitoring of blood concentrations of sulfamethoxazole. If the index is more than 150 ug / ml, then the treatment is stopped until a value of 120 ug / ml and below. If the treatment is intended for a month or more, it requires regular monitoring of the blood. In appointing folic acid   hematologic changes are reversible. In AIDS patients the side effects are more common and are pronounced. Biseptolum not recommended at pharyngitis   and tonzilittah caused by beta-hemolytic streptococcus c. A.

Drug Interactions:

Biseptolum enhances the effect of hypoglycemic drugs, indirect anticoagulants, methotrexate. The drug reduces the efficiency and reliability of the oral contraceptive. The risk of megaloblastic anemia increases while receiving pyrimethamine (more than 25 mg per week). Thiazides may result in thrombocytopenia. Efficiency reduces Biseptol procainamide .   procaine . benzocaine . The drug leads to the development of cross-allergies while admission to oral hypoglycemic drugs. Folic acid deficiency is enhanced by the appointment of barbiturates, phenytoin, Pasco. Crystalluria develops when receiving hexamethylenetetramine ascorbic acid.