Description overdue on 05.02.2012

Bacteriostatic antibiotic . The principle of operation is based on binding to ribosomal subunits, which leads to destruction of the peptide bonds between the amino acid molecules, blocked the process of protein synthesis in the microorganism. It affects gramoplozhitelnye cocci, gram-negative flora. Erythromycin - receptor agonist motilin . The drug increases the rate of evacuation in the digestive tract due to the effect of reducing the amplitude of the pylorus exerts a positive effect on antral-duodenal coordination . Erythromycin is available in tablet form, in the form of ointment, solution.

Indications:

Erythromycin is indicated for infections of bacterial etiology: trachoma . whooping cough . erythrasma . diphtheria . listeria . Legionnaires' disease, brucellosis . scarlet fever . gonorrhea . amoebiasis . pneumonia   children, primary syphilis , Uncomplicated Chlamydia . sinusitis . cholecystitis . tonsillitis . otitis . tracheitis , Acne vulgaris, bronchitis . Erythromycin is prescribed for the prevention of streptococcal infection in patients with rheumatism . At allergies   Penicillin is an antibiotic reserve.

Contraindications:

Erythromycin is not used with a significant hearing loss, intolerance components, pregnancy, when taking astemizole, terdenatsina. When arrhythmias, breastfed jaundice , Renal disease administered with caution.

Side effects and overdose:

Hearing : ototoxicity . Digestive system : Tenesmus, epigastric pain, dysbiosis , Vomiting, cholestatic jaundice, candidiasis of the mouth, pancreatitis . Cardiovascular system : Atrial flutter, atrial fibrillation . Perhaps the development of phlebitis   at the injection site, allergies, eosinophilia. If overdose is registered acute renal failure, impaired hearing. Recommended timely gastric lavage, the use of enterosorbents . Forced diuresis , Peritoneal dialysis and hemodialysis bring no effect.

Mode of application:

Erythromycin taken one hour before meals, drinking plenty of fluids. The average dose for adults - 200-400 mg every 6 hours. If necessary, the daily dose may be increased to 4 grams. Erythromycin children: 40 mg / kg per day for 2-4 reception. Duration of antibiotic treatment 7-10 days.

Special instructions:

In severe bacterial infection Erythromycin administered intravenously as erythromycin phosphate. At the time dosing was stopped breast feeding. With long-term antibiotic therapy is carried out regular monitoring of liver function. Ototoxicity manifests itself most often in patients with abnormal renal system. Tablets can not drink milk products, milk.

Drug Interactions:

Erythromycin has a negative effect on the bactericidal activity   carbapenem , Cephalosporin, penicillin and other beta-lactam antibiotics. When intravenously marked potentiation of ethanol is amplified nephrotoxicity   cyclosporin. Antibiotic reduces the clearance of midazolam, triazolam, slows the rate of elimination coumarin anticoagulants , Felodipine, methylprednisolone. Rhabdomyolysis   enhanced, while admission lovastatin. Erythromycin enhances the bioavailability Digoxin . A negative impact on the effectiveness of hormonal konratseptsii. Arrhythmia develops while entering astemizole and terdenadina. The drug is not compatible with chloramphenicol, clindamycin.