Description overdue on 09.02.2012

Antibiotic.   Semisynthetic macrolide It has a bacteriostatic effect. The mechanism of action is based on the binding subunit of the ribosome, inhibiting the reaction transpeptidation   and translocation . The drug has an effect on the formation of peptide bonds between the peptide chain and amino acids, inhibits protein synthesizing ribosome Which leads to inhibition of growth and reproduction of the bacterial cells. Roxithromycin noted stability during the action of an acidic medium. Available in tablet form.

Indications:

Roxithromycin prescribed for infection of the respiratory tract (upper, lower): bronchiectasis, infection in COPD, pneumonia , Panbronchiolitis, pharyngitis Bronchitis. The drug is effective in bacterial infection of upper respiratory tract (middle otitis . tonsillitis .   sore throat . sinusitis ), Soft tissue and skin (pyoderma, folliculitis, phlegmon , Erysipelas, boils, impetigo), urinary system ( vaginitis , Except for STDs gonorrhea . endometritis . urethritis . cervicitis ), Bone ( osteomyelitis . periostitis ). The drug used in the periodontitis . brucellosis , Erythematous rash, trachoma, whooping cough . Diphtheria . scarlet fever . Roxithromycin prescribed for prophylaxis in contact persons   Meningococcal meningitis Patients with endocarditis   after dental procedures.

Contraindications:

Roxithromycin is not indicated for the treatment of dihydroergotamine, ergotamine, intolerance components, breastfeeding, in pediatric patients until 2 months of pregnancy. When kidney disease is prescribed with caution.

Side effect:

Roxithromycin may cause dysgeusia, nausea, epigastric pain, diarrhea, elevated liver enzymes, flatulence, hepatocellular acute hepatitis, cholestatic hepatitis, pseudomembranous enterocolitis , Pancreatitis, paresthesia, allergic reactions (redness of the skin, bronchospasm , Anaphylactic shock), pigmentation of nails, vaginal candidiasis Candidiasis of the mouth, superinfection . In case of overdose gastric lavage is shown urgent treatment posimptomnoe, the antidote is not developed.

Mode of application:

Roxithromycin taken orally twice a day at 150 mg or 300 mg single dose. The duration of 5-12 days of antibiotic therapy for infections of upper respiratory tract and respiratory system. During the chronic osteomyelitis treatment can last up to 2, 5 mesyatsey. If mycoplasma pneumonia and chlamydia genesis Roxithromycin take 2 weeks, with Legionella pneumonia - 3 weeks. If renal disease taking 150 mg single dose. Babies illustrates reception suspension - 5 mg / kg per day, for no longer than 10 days. The suspension should be prepared the day before admission: special measuring spoon with water dissolved ½ or 1 tablet, after the collapse of the child to give, it is recommended to wash down with water.

Special instructions:

Pathology hepatic system requires regular monitoring of the performance of the liver.

Drug Interactions:

Roxithromycin enhances absorption Digoxin . When taken with warfarin increases fenprokoumonom prothrombin time . It strengthens and increases the duration of action midozalama . Increases concentration Cyclosporin A   and theophylline in blood. Roxithromycin concentration increases pimozide, astemizole and cisapride serum. Ergotaminpodobnye and vazoknstriktory ergotamine   cause the formation of "ergotism" nekrotizirovanie tissues. In the blood displaces dizopiramid in the fight for blood proteins.