Description overdue on 02.03.2012

Cephalosporin antibiotic . It is used parenterally. Cefazolin bactericidal effect. The mechanism of antibacterial action is based on inhibition of the process of synthesizing in the cell wall of the microbe. The drug acts on gram-positive, gram-negative bacteria, enterobacteria , Indolpolozhitelnye strains Mycobacterium tuberculosis , Anaerobic microorganisms. Cefazolin is produced as a lyophilisate, powder.

Indications:

Cefazolin is prescribed for infection of upper respiratory tract, respiratory tract, biliary tract, urinary tract, with endocarditis . osteomyelitis , Infection of the joints, bones, soft tissue of the pelvic organs. Antibacterial drug is effective in syphilis , Burn infections, wound, post-operative bacterial lesions in the mastitis . peritonitis Sepsis. The drug is indicated for the prevention of infection in surgical interventions.

Contraindications:

Cefazolin is not prescribed to babies until the age of one month. The drug is contraindicated in colitis , Bowel disease, impaired renal system hypersensitive.

Side effect:

The urinary system : In the pathology of the renal system Cefazolin can provoke increase in nitrogen kreatinina urea. Digestive system: pseudomembranous enterocolitis , Hepatitis, cholestatic jaundice , Epigastric pain, diarrhea, vomiting, nausea. Allergic response:   eosinophilia, bronchospasm . itching , Hyperthermia, angioedema , Stevens-Johnson syndrome, anaphylactic shock. Bodies of blood: hemolytic anemia , Thrombocytosis, thrombocytopenia, neytrpoeniya. Long-term treatment leads to the development of superinfection, dysbiosis , Candidiasis, of resistance to the antibiotic. The laboratory values ​​can be registered positive Coombs' test, hypercreatininemia , Elevation of liver enzymes, increased prothrombin time. When administered intravenously, possible pain during the injection, the subsequent development phlebitis .

Mode of application:

Cefazolin is administered jet, drip. The average dose for adults - 1-4 grams per day, three dose. At night no more than 6 grams. The course of treatment lasts up to ten days. Prevention of postoperative complications intravenously one hour preoperatively administered 1 gram of antibiotic, during operation - one gram, then after the operation cefazolin administered every 8 hours to 0, 5-1 grams. In the pathology of renal dose is calculated depending on the level kreatininikinazy. Before the drip, intravenous drug diluted in 100 ml of dextrose (5-10%), Ringer's solution. Dilution vials vigorously shaken to complete dissolution.

Special instructions:

In patients with a history of allergic response to carbapenems, penicillins may develop hypersensitivity when using the drug Cefazolin. The treatment period can be recorded false positive reaction for the presence of urine sugar positive reactions during the direct, indirect Coombs test. Against the background of antibacterial therapy may increase colitis, diseases of the digestive tract. Antibiotic solution remains stable after thawing for ten days when stored (5 degrees Celsius). At room temperature Tskfazolin remains active for two days. Reliable information about the drug's safety for infants and premature infants do not.

Drug Interactions:

Cefazolin is not recommended for use in conjunction with diuretics and anticoagulants . Co-administration with loop diuretics leads to the development of the blockade tubular secretion. Mutual inactivation is registered in the appointment aminoglycosides , Besides, they increase the risk of renal pathology system. Drugs that block tubular secretion, increase the concentration of drug in the blood, reduce the rate of excretion of metabolites increases the risk of toxicity, side effects and reactions.