Description overdue on 24.05.2012

Antimicrobial . The active ingredient is a derivative of nitrofurans. The drug acts on Trichomonas, Shigella, Salmonella, gram-positive and gram-negative bacteria flora. The drug is poorly active against anaerobic, purulent infection . The principle effects of the antimicrobial agent is based on blocking the monoamine oxidase. Action nitrofurans directed to a violation of flow of respiration of microorganisms at the cellular level, the suppression of tricarboxylic acids in the Krebs cycle, inhibition of most biochemical processes in microorganisms, which leads to the destruction of the membrane and cytoplasmic membranes of bacteria. Under the influence of the drug reduced the amount allocated to micro-organisms toxins That improves overall patient before the time suppressing the growth and reproduction of microorganisms. Resistance to the effects of the drug flora furazolidone develops very slowly. Furazolidone available in tablet form and in the form of granules.

Indications:

Furazolidone prescribed for food poisoning, with giardiasis, paratyphoid, dysentery . urethritis . Trichomonas coleitis Infected burns and wounds.

Contraindications:

Furazolidone is not prescribed for pregnant women, children under one year, breastfeeding, ESRD. In diseases of the nervous system, liver system of the drug is used with caution.

Side effect:

Anorexia , Vomiting, nausea, loss of appetite, angioedema , Itchy skin, redness of the skin.

Overdose:

Polyneuritis Acute toxic hepatitis. When high doses of the drug there is a high risk neurotoxicity   and gematotoksichnosti . Therapy is aimed at introduction of a large volume of liquid, the purpose of the B vitamins, antihistamines .

Mode of application:

Furazolidone tablets are taken orally. When nutritional diseases, paratyphoid, dysentery, drug taking 4 times a day 1500 mg, the course is designed for 5-10 days. Trichomonas coleitis three days 100 grams 3-4 times, to simultaneously introduce into the vagina 5-6 grams of powder which contains lactose and furazolidone in a ratio of 1: 500, rectally administered candles which contain 4-5 grams of the base material. The duration of antimicrobial therapy is 7-14 days. Treatment of Urethritis Trichomonas 4 times a day, 100 mg, 3 days. Giardiasis: 4 times a day on 100mg. Furazolidone children when giardiasis appoint scheme 10mg / kg per day. Treatment of wound infections, burns directed to the application of a wet-drying with sodium furazolidona dressings and irrigation surfaces. Furazolidone children prescribe in a dose, twice less adult.

Special instructions:

Furazolidone can increase inhibition of hematopoiesis   when receiving ristomycin, chloramphenicol. The medicament may be used for the treatment of alcoholism by improving sensitivity to the effects of ethanol. Drugs that acidify the urine - increase the effectiveness of the drug, and the drug that was made alkaline urine - decrease. Antimicrobial properties furazolidona intensified while taking tetracycline, aminoglycosides. When long-term therapy for the prevention neuritis recommended to appoint B vitamins in the period of application of the drug is necessary to observe all safety precautions provided when taking MAO inhibitors.

Drug Interactions:

Development disulfiramopodobnyh reactions possible with a combination of the drug with ethanol. Ephedrine . antidepressants , Phenylephrine, amphetamine, MAO inhibitors , Tyramine can cause a sudden rise in blood pressure.