Description overdue on 05/19/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Hemomitsin
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Hemomitsin children
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Which is better: Sumamed or Hemomitsin?
• Price, where to buy

Composition

Composition capsules Hemomitsin :

One capsule contains active substance: Azithromycin   - 250 mg (as azithromycin dihydrate   - 262, 03 mg). Excipients: lactose anhydrous, maize starch, magnesium stearate . sodium lauryl sulfate . The capsule shell consists of titanium dioxide, dye proprietary blue gelatin.

Composition powder for suspension   oral (5 ml):

Active ingredient: azithromycin   - 100 mg or 200 mg per dosage depending (as azithromycin dihydrate   - 104, 809 or 209 mg, 6 mg, depending on the dosage). Excipients: xanthan gum . colloidal silica . sodium saccharinate . calcium carbonate , Strawberry flavor, sodium phosphate anhydrous . sorbitol Apple flavor, cherry flavor.

Composition film coated tablets :

One tablet contains active substance - Azithromycin - 500 mg (as azithromycin dihydrate ). Excipients: silicate pulp . MCC . sodium carboxymethyl . povidone . magnesium stearate Talc, colloidal silica .
The composition of the coating film includes: ethyl cellulose . titanium dioxide . talc . macrogol 600 . indigo carmine . copovidone , Lacquer dye green, quinoline yellow.

Composition Valium for infusion solution :

One vial contains Azithromycin   (as dihydrate ) 500 mg. Excipients: citric acid monohydrate . mannitol . Sodium hydroxide .

Product form

Hemomitsin comes in four forms:

• Capsules   - Blue color is contained inside a white powder; 6 of these capsules in a blister, a blister in a cardboard box.
• Powder   for suspension for oral administration - has a white or close to white color with a fruity aroma (cooked slurry has almost white color with a fruity aroma); 10 g (at a dose of 200 mg) or 11 grams of 43 (at a dose of 100 mg) of powder in a dark glass vial with a measuring spoon, a bottle and a measuring spoon in the carton box.
• Pills   - Round shape with convex sides coated blue; three of these tablets in a blister, a blister in a cardboard box.
• Lyophilizate   a powder or compressed into tablets weighing white; 500 mg of this powder in a glass vial, one such vial in a carton box.

Pharmacological action

Sun (bactericidal and bacteriostatic) action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Azithromycin   It refers to azalides newly synthesized group macrolide antibiotics . Once in the cell of a microorganism, it reacts with the 50S-70S-ribosomal subunit, thus stopping RNA -dependent protein production and stopping the reproduction of bacteria. Upon reaching a high concentration of azithromycin produces a bactericidal effect.

It has a wide range of antibacterial action . Sensitive organisms to azithromycin:

• gram-positive cocci   - Ruogenes Streptococcus, Streptococcus pneumonie, C, F and G group streptococci, Streptococcus agalactiae, S.viridans ;
• Staphylococcus aureus ;
• Gram negative bacteria   - Legionella pneumophila, Bordatella pertussis, Haemophilus influenzae, H. rarainfluenzae, Neisseria gonorrhoeae, H. ducrei, B. rarapertussis, Campylobacter jejuni, Gardnerella vaginalis   (azithromycin no effect on gram-positive microorganisms that are resistant to erythromycin );
• anaerobic bacteria   - Clostridium perfringes, Ureaplasma urealyticum, Bacteroides bivius, Peptostreptococcus species , and Mycoplasma pneumoniae, Chlamidia trachomatis, Treponema pallidum .

Pharmacokinetics

Azithromycin is rapidly adsorbed from the digestive tract. Bioavailability   It reaches 37%. The maximum concentration of azithromycin in blood achieved through 3-3, 5 hours after ingestion. The drug penetrates well into tissues respiratory   and genitourinary system As well as in skin and soft tissue. Antibiotic Hemomitsin accumulates in high concentrations in macrophages, which deliver it to the infectious-inflammatory center and release.

Third azithromycin is metabolized in the liver, another half displayed in its original form the composition of bile, the remaining part - in urine within three days. The half-life of 14-19 hours.

Indications

Infectious-inflammatory:

• Respiratory and ENT ( sinusitis . sore throat . tonsillitis . pneumonia . otitis media . bronchitis ).
• Soft tissue and skin ( impetigo . mug , Secondarily infected Medicine ).
• Urinary tract ( urethritis . cervicitis ).
• Stomach and duodenum 12 associated with Helicobacter pylori   (as part of a multicomponent treatment).
• And Lyme disease   and scarlet fever ;

Contraindications

• Allergies   to azithromycin or another representative of the group macrolides .
• Severe liver disease, kidney disease.
• Lactation.
• Carefully: pregnancy . arrhythmia   (possible violations of ventricular rhythm and lengthening of the interval QT); children with severe changes in liver or kidney function.
• Age under 12 years old and weighing 45 kg in children (capsules, tablets and suspension dosage 200 mg) and 6 months (for suspension dosage 100 mg).
• With care given during pregnancy and arrhythmias.

Side effects

Side effects caused by capsules:

• From the digestive tract: nausea, abdominal pain, diarrhea , Vomiting, transient increase activity transaminases   and other liver enzymes; rarely - melena . jaundice .
• Dermatological reactions: rash .

Suspension and tablets may cause the following side effects:

• From the digestive tract: diarrhea , Vomiting, nausea, abdominal pain, flatulence, melena . jaundice Temporary increase in activity transaminases ; children - loss of appetite, constipation, gastritis .
• On the part of the cardiac system: tachycardia Pain in the chest.
• On the part of the central nervous system: pain in the head, dizziness, drowsiness; children - hyperkinesia , Anxiety, insomnia.
• With the genitourinary system: jade (rarely), vaginal candidiasis .
• Allergic reactions: rash,   angioedema ; children - conjunctivitis . hives .
• In very rare cases - candidiasis   oral cavity.

Instructions for use Hemomitsin

Instructions on Hemomitsin recommends taking antibiotics orally (tablets, suspension, capsules) once a day for 1 hour before or 2 hours after a meal, as food intake joint Hemomitsin reduces the bioavailability of the drug.

• When infectious and inflammatory diseases of the respiratory adult Hemomitsin prescribed dosage of 500 mg per day for three days.
• In infectious and inflammatory diseases of soft tissues and skin, and also in the initial stage Lyme disease   1 gram administered on the first day, then - 500 mg once a day from the second to the fifth day.
• In acute urethritis   or cervicitis   recommend a single 1 gram of azithromycin.
• In diseases of stomach and duodenal ulcers associated with Helicobacter pylori, take 1 gram per day for 3 days in a multicomponent composition Helicobacter therapy.
• When infectious and inflammatory diseases of the respiratory tract, skin and soft tissues of children from 12 years of drug is given at the rate of 10 mg / kg 1 time a day for 3 days, the treatment of early stage Lyme disease   - 20 mg / kg on the first day and 10 mg / kg in the second to fifth day.

Preparation of slurry

In a bottle, wherein the powder is slowly added to the cold clean water mark. Then the bottle is shaken until a homogeneous suspension. Immediately after taking the form of a suspension in Hemomitsin child needs to drink a small amount of pure water to swallow suspension of residues in the mouth.

Powder for infusion

Hemomitsin for the preparation of infusions used strictly in stationary medical institutions.

Overdose

Typical signs of overdose: a temporary hearing loss, abdominal pain . nausea Possible vomiting , Loose stools.

Treatment of overdose: reception Activated Carbon Symptomatic therapy. There is no specific antidote.

Cooperation

At simultaneous reception Azithromycin   and antacids   bioavailability first is not changed, but the concentration in the serum is reduced on average by 25%. Hemomitsin recommended one hour before or two hours after ingestion of antacids.

We know of cases of metabolic changes Digoxin   when one-time admission to macrolides . In particular, such a method with digoxin increases the concentration of azithromycin in the first plasma.

Patients taking macrolide antibiotics   with ergot derivatives, sometimes showing signs of poisoning alkaloids last. Therefore it is not recommended to prescribe azithromycin with ergot derivatives.

It is recommended to be used with caution together with azithromycin cyclosporine   or theophylline , As this may increase their concentration in the blood.

In patients receiving azithromycin rifabutin   at the same time may develop neutropenia.

Joint reception cisapride   azithromycin and is in some cases ventricular   and mertsatlnuyu arrhythmia .

Linkozaminy   reduce the effectiveness of azithromycin and tetracycline   and chloramphenicol   on the contrary increase.

It prohibited the simultaneous treatment with azithromycin and Heparin .

Ergotamine   and its derivatives enhance the toxicity of azithromycin can cause vasospasm, and the change of sensitivity.

Terms of sale

Hemomitsin released strictly on prescription.

Storage conditions

• Store in a dry, dark place.
• Store at a temperature of 15 ° C to 25 ° C.
• Keep away from children.

Shelf life

3 years.

Cautions

It does not take Hemomitsin with food or antacids .

Allergic reactions in some patients may persist after treatment Hemomitsin.

Analogs Hemomitsin

Analogs of the preparation are numerous, here are some of them: Azitromaks . Azithromycin . Ziomitsin . Zitrotsin . Zomax . Sumamed .

Hemomitsin children

The antibiotic in the form of capsules and tablets for receiving banned for children under 12 years. Permitted receiving a suspension for children older than six months. The dosage for children is calculated by the attending physician based on the particular situation.

Testimonials indicate performance Hemomitsin use in children, but there are reports of occurrence of side effects.

Children with liver or kidney disease should be prescribed with caution.

With alcohol

It is forbidden to drink alcohol during treatment Hemomitsin.

During pregnancy and lactation

Admission Hemomitsin during pregnancy or while breast-feeding is justified if the intended benefits from taking it outweigh the risks for the child. The decision on taking the drug makes only doctor or medical consultation.

Reviews Hemomitsin

Reviews on the forums about Hemomitsin allow to form a positive opinion about the effectiveness of the drug. However, the use of the drug for children can result in the occurrence of side effects from the gastrointestinal tract (frequent posts about it).

Which is better: Sumamed or Hemomitsin?

The drugs have the same composition and largely repetitive form of release and dosage. Reports of the use of drugs do not show a significant difference in the results of the treatment in the direction of any of them. So often patients choose Hemomitsin due to lower prices.

Price Hemomitsin

In Russia, the price of Hemomitsin 500 mg (tablets) ranges from 285 to 305 rubles, the price of the antibiotic capsules of 250 mg from 250 to 310 rubles, the price Hemomitsin suspension 200 mg / 5 ml (manufactured for children) - 214-230 rubles and a suspension 100 mg / 5 ml - 130-140 rubles.

In Ukraine, the average price Hemomitsin tablets 500 mg - 83 hryvnia, capsules of 250 mg - 88 hryvnia, the suspension 100 mg / 5 mL and 200 mg / 5 ml - 75 and 115 hryvnia, respectively.