Description overdue on 30.07.2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Ofloksina (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

Ofloksin 200 mg

1 tablet contains 200 mg ofloxacin .

Auxiliary substances include: corn starch, poloxamer, magnesium stearate, lactose monohydrate, crospovidone, povidone, talc; in the shell shell comprises hypromellose, macrogol, titanium dioxide, talc.

Ofloksin 400 mg

1 tablet contains 400 mg ofloxacin .

Auxiliary substances include: corn starch, magnesium stearate, poloxamer, lactose monohydrate, crospovidone, povidone, talc; in the shell shell comprises hypromellose, macrogol, titanium dioxide, talc.

Product form

Ofloksin comes in tablet form round biconvex shape white without impurities and foreign smell. Coated tablets and have to share the risks. Depending on the dosage on one side is engraved " 200 "Or" 400 ". At the break - pressed white mass.

Contour cell blisters placed into cardboard boxes.

In each pack have to be detailed instructions for use of the drug.

Pharmacological action

Bactericidal (Anti-bacterial).

Pharmacodynamics and pharmacokinetics

Ofloxacin   is antimicrobial broad-spectrum bactericidal action. It belongs to the group fluoroquinolones . The main impact of ofloxacin has on enzyme DNA gyrase, which provides the bacterial DNA supercoiling. Preparation destabilizes the DNA chain that leads to the death of microorganisms.

Ofloxacin It has high activity against microorganisms that produce β-lactamase, and is also used to deal with such fast-growing atypical mycobacteria like Enterobacteriaceae (Salmonella, Serratia, Citrobacter, Klebsiella, Yersinia) . Escherichia coli, Enterobacter spp., Shigella spp., Providencia spp., Proteus spp.

Effective preparation is the same and cons staphylococci   (In Vol. H. Penitsillinazoprodutsiruyuschih and methicillin-resistant strains ( Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycobacterium tuberculosis Mycobacterium leprae, Ureaplasma urealyticum ).

Good results show the drug in the treatment of diseases caused by mycobacteria following: Pasteurella multocida, Pseudomonas spp., Brucella melitensis, Haemophilus influenzae, Campylobacter spr., Neisseria meningitidis, Branhamella catarrhalis, Vibrio spr., Pseudomonas aeruginosa.

It is advisable to use the antibiotic and the active breeding Helicobacter pylori, Acinetobacter spr., Neisseria gonorrhoeae, Haemophilus ducreyi, Gardnerella vaginalis.

Ofloksin less active against infections caused by   group A streptococcus, B, C.   Also, no significant sensitivity to the drug and have anaerobes except Clostridium perfringens . In these cases, ofloxacin has minimal impact and potential for slowing the reproduction of these bacteria make better use of other drugs.

Completely insensitive to the drug anaerobic bacteria Fusobacterium spp., Bacteroides spp., Peptococcus spp., Peptostreptococcus spp and.

Inactive Ofloksin and in relation to Treponema pallidum.

Absorption

Before the drug absorption is complete (95%) and fast. Bioavailability greater than 96%. Cmax while taking the drug in doses of 100 mg, 300 mg and 600 mg, respectively, reaches 1 mg / l, 3, 4 mg / L and 6, 9 mg / l. In single dose of the drug in a dosage of 200 mg and 400 mg Cmax reaches 2.5 g / mL and 5 ug / ml. It should be noted that the meal will slow the absorption, but does not significantly affect the bioavailability.

Allocation

Ofloxacin binding to plasma proteins is 20-25%. The apparent Vd reaches 100 liters.
The drug is easily penetrates into many fluids and tissues (lacrimal and spinal fluid, urine, saliva, bronchial secretions, and so on. D.) Also, ofloxacin freely crosses the placental barrier and the blood-brain barrier, and is excreted in breast milk. Penetration of the drug in the cerebrospinal fluid ranging from 14 to 60%. Ofloxacin is not cumulate.

Metabolism

Metabolism   It occurs in the liver. Dimetilofloksatsin forms and N-oxide of ofloxacin.

Withdrawal

T1 / 2 when administered independently of the dose is excreted through 4, 5-7 hours. Derivation is performed by the kidneys (75-90%) and bile (4%). Extrarenal clearance is about 20%. Patients with renal or hepatic impairment should be remembered that the T1 / 2 of the drug increases. With a single application of 200 mg ofloxacin can be detected in the urine within 20-24 hours.

Indications

Ofloksin well established in the treatment of:

• severe respiratory tract infections ( bronchiectasis . lung abscess . pneumonia );
• infection of upper respiratory tract ( otitis media, sinusitis, pharyngitis, laryngitis   /with the exception of acute tonsillitis   /);
• bone and joint infections;
• soft tissue infections and skin;
• infectious and inflammatory diseases of the abdominal cavity (gastrointestinal infections, biliary tract / Save bacterial enteritis   /);
• kidney infection ( pyelonephritis );
• urinary tract infections ( urethritis, cystitis );
• pelvic infection ( endometritis, salpingitis, cervicitis, parametritis, prostatitis );
• severe infections of genitals ( orchitis, vaginitis, epididymitis, gonorrhea, prostatitis );
•   meningitis ;
• Chlamydia ;
• associated infections in AIDS ;
• eye infections ( conjunctivitis . bacterial corneal ulcers, blepharitis, dacryocystitis, meybomita, keratitis ).

Also Ofloksin actively used:

• in the prevention of infection after surgery in connection with the removal of foreign body or eye injury;
• when combined therapy TB ;
• in the prevention of infections in patients with immunocompromised   ( neutropenia ).

Contraindications

Should refuse to accept Ofloksina:

• at deficiency of glucose-6-phosphate dehydrogenase ;
• at epilepsy   (including history);
• at   reducing the seizure threshold   (in t. h. stroke . traumatic brain injury   or any inflammatory processes in the CNS).

Ofloksin contraindicated:

• persons under the age of 18;
• persons with hypersensitivity to the drug.
• pregnant women;
• women during lactation.

Caution should be used for people with drug-related disease and cerebrovascular cerebral atherosclerosis . With chronic renal failure   and organic CNS   it is advisable to choose the drugs for treatment of the same spectrum of action, but less dangerous.

Side effects

During treatment, the patient may feel Ofloksinom discomfort and suffer from:

• On the side   digestive system: nausea, vomiting, diarrhea, flatulence, abdominal pain (including gastralgii ), Increased liver transaminases .   hyperbilirubinemia, cholestatic jaundice, pseudomembranous enterocolitis.
• On the side   Peripheral nervous system   and   CNS: headache, dizziness, lack of movement, tremor, seizures, numbness   and paresthesias of extremities, intense dreams, nightmares, psychotic reactions, anxiety, hyperexcitability,   phobias, depression, confusion, hallucinations , Increased intracranial pressure.
• On the side   senses : disorders of color perception, diplopia, the taste, hearing, smell and balance.
• On the side   Cardiovascular : tachycardia, vasculitis, collapse.
• On the side   Musculoskeletal System : tendinitis, myalgia, arthralgia, tendonitis, tendon rupture.
• On the side   hematopoietic system : leukopenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, hemolytic   and Aplastic anemia.
• On the side   urinary systems : acute interstitial nephritis, renal dysfunction, hypercreatininemia, increase of urea.
• Allergic reactions: skin rash, itching, hives, hypersensitivity pneumonitis, allergic nephritis, eosinophilia, fever, angioedema, bronchoconstriction, Stevens-Johnson syndrome, Lyell's syndrome, photosensitivity, erythema multiforme exudative, anaphylactic shock.
• Dermatological reactions: petechial hemorrhages (petechiae), hemorrhagic bullous dermatitis, papular rash, vasculitis.
• And: dysbiosis, superinfection, hypoglycemia (in patients diabetes ) vaginitis .

Instructions for use Ofloksina (method and dosage)

Due to the fact that Ofloksin used to treat a wide range of diseases, the dosage of the antibiotic is individually and depends not only on the severity and localization of the infection, and the general condition of the patient. Special attention to the instructions Ofloksin 400 mg should be paid to liver and kidney function.

The adult dose of 200 mg administered 2 times a day, or 400 mg 1 time per day. The maximum daily dose should not exceed 800 mg. The course of treatment is determined by the sensitivity of the pathogen and often is 7-10 days. Preferably in the morning to take the drug for 30-60 minutes before eating. To wash down pills to be a small amount of water.

Before taking this medication, it is imperative to consult a doctor, as the dosage for the treatment of various diseases can vary.

Overdose

In case of overdose, the patient may experience the following symptoms:

• confusion ;
• disorientation ;
• lethargy ;
• vomiting ;
• drowsiness ;
• dizziness .

To eliminate these symptoms should promptly wash the stomach and further treatment use symptomatically .

Cooperation

When receiving the drug inside it should be remembered that significantly reduces the absorption of ofloxacin foods containing large amounts of calcium, aluminum, magnesium and iron salts, because they form insoluble complexes. Care should be taken so that the interval between doses and Ofloksina these substances is at least 2 hours.

At reception   ofloxacin 25% less theophylline clearance   and in this situation it is advisable to reduce the dose theophylline .

Particular attention should be paid to drugs that block tubular secretion Because their simultaneous reception Ofloksinom can greatly increase the concentration of ofloxacin in the plasma.

Concentration glibenclamide   Plasma is also dependent on Ofloksina.

It should not be taken simultaneously with Ofloksin vitamin K antagonists Since this could negatively affect the state blood coagulation .

Derivative nitroimidazole and methylxanthines at a joint reception may cause the development of neurotoxic effects , a GCS   It increases the risk of tendon rupture, which is especially dangerous for the elderly.

Admission Ofloksina with drugs that alkalized the urine may lead to an increased risk of the emergence and development nephrotoxic effects and   crystalluria .

Terms of sale

The drug prescription.

Storage conditions

Ofloksin should be stored in a dry place at a temperature not exceeding 25 ° C.
The drug should not be available to children.

Shelf life

Ofloksina Shelf life is 3 years.

Analogs

Currently Ofloksin has about 20 counterparts from both domestic and from foreign manufacturers. The most popular today are drugs such as: Zanotsin, Ofloxacin, Oflotsid and   Lofloks .

Also structural analogs of the active substance are: Vero Ofloxacin, Glaufos, Danzi, Unifloks, Floksal.

Reviews Ofloksine

Evaluation Ofloksina in forums ranging from 1 to 5 on the 5-point scale.

After analyzing the responses of visitors medical forums, we can conclude that the patients who completed the full course of treatment were fully satisfied with the results of treatment. Low assessment of the drug often puts visitors who Ofloksin cause severe side effects. Most often on the forums, patients complain of severe stomach pain, decreased appetite Appearance thrush, lethargy, drowsiness   and even night   hallucinations .

Ofloksin - an antibiotic or not?

Many discussion forums devoted to the subject. Then experts give a definite answer that Ofloksin is quite powerful antibiotic and advise patients in whom this drug causes severe discomfort, choose to treat less toxic drugs.

Information about the preparation Ofloksin Wikipedia there.

Price Ofloksina where to buy

The average price for Ofloksin in Ukraine depends on what dosage of the drug you are interested in. Price Ofloksin 400 mg   150 UAH, and the price 200 mg   94 UAH.

Price Ofloksina in Moscow is 298 rubles. and 165 rubles. respectively.