Description overdue on 16.01.2012

Antifungal preparations . Griseofulvin is synthesized in fungal cells Penicillinum nigricans. Griseofulvin - antifungal, the drug was being used in the treatment of lesions of the skin, hair and nail fungal etiology. Has expressed fungistatic effect   on fungi dermatomitsetami   (pathogens fungal diseases of the skin) to the genus trihofiton   (trihofitii pathogens - disease of scalp hair and nail diseases), to the exciter microsporia On fungi epidermofiton   (pathogens epidermophytosis   - Inflammatory diseases of the skin at the groin and feet, as well as diseases nails). Fungistasis griseofulvin due to the fact that the drug inhibits the processes of cell division in metaphase fungus and violates the structure of the fungus. Ineffective against yeast fungi of the genus Candida, when candidiasis   not appointed. Griseofulvin well absorbed through the intestinal wall and in the human body exhibits pronounced tropism for lipophilic horny layer of the skin, to the hair and tissues of the nail bed. Due to these properties, a high concentration of the drug is in the lesions. Griseofulvin metabolism occurs in the liver and displays the drug from the body through the intestine and kidney. Half-life griseofulvin - 24 hours.

Indications:

The lesions of the skin, hair and nail fungal origin ( ringworm ): Onychomycosis (nail bed and pathology of the nail plate) trichophytosis . crusted ringworm   (in these diseases primarily affect hair) microsporia, athlete's skin, fungal feet, hands.

Contraindications:

Griseofulvin is contraindicated in severe lesions of the kidney and liver, porphyria   (a group of diseases associated with metabolic disorders of pigments). You can not assign Griseofulvin If a patient is malignant neoplasms, when expressed leukopenia , Changing the cellular composition of the blood and blood-forming organs systemic diseases. With diabetes   should renounce the use of griseofulvin suspension, since the latter contains glucose. During pregnancy and breastfeeding Griseofulvin is not assigned. Avoid prescribing when a patient has systemic connective tissue diseases and episodes acute stroke   history.

Side effect:

Griseofulvin may cause disruption of the digestive system, in particular, patients may begin to complain of pain in the epigastric region, the emergence of dyspeptic disorders   in the form of nausea and even vomiting. In rare cases, there may be frustration of a chair   (or constipation Or diarrhea ). Central nervous system   may cause headaches, dizziness, and neurological symptoms asthenovegetative. In rare cases may develop photosensitivity   (increased sensitivity to the action of visible light and ultraviolet rays). Griseofulvin can cause disorders of the blood, which will be manifested by leukopenia, or other similar changes in the morphological picture of blood. When these side effects should choose watchful waiting and stop taking the drug for three to four days. The skin may experience allergic rashes, up to erythema multiforme   and skin necrolysis .

Mode of application:

Griseofulvin is available in two forms for oral administration: tablets of 125 milligrams and a suspension, one milliliter containing 100 milligrams of active compound. It is also the form of griseofulvin topical - 2, 5% Liniment 30g in the bank. The tablets should be taken orally 1 h. Liter. vegetable oils mealtime. The suspension   administered to children up to three years. Embrocation   used for localized skin lesions alone, plus in conjunction with griseofulvin reception inside with more extensive lesions. When microsporia   adult prescribed to 8 tablets per day, children - 21-22 milligrams per kilogram of body weight per day. The duration of therapy is defined as follows - Griseofulvin take every day to the first negative results of tests on the mushrooms, then keep the dose for another two weeks, but already taking the drug every other day, and after two weeks of dosing frequency reduced to two times a week. When favus and infiltrative-suppurative trihofitii   Griseofulvin prescribed for adults in the same dosage and in the same way, for the treatment of children should make a correction of the dose - 18 milligrams per kilogram of body weight per day, the scheme is not changed. In the course of treatment of fungal infections of the head is necessary once a week to shave the hair and wash your hair with soap and water twice a week. Griseofulvin dosage will depend on the weight of the body, so with the weight up to 50 kg less than five tablets (625 milligrams). When the body weight over the above figures per 10 kg should be added one tablet griseofulvin, but not more than a gram per day. The daily dose for children and adolescents is calculated as 16 milligrams per kilogram of body weight. Treatment of onychomycosis   held as follows: taking Griseofulvin for a month every day, and from the second month - every two days, and then go on Centauri twice a week. Duration of treatment - eight months or more (to treatment may take a year). In the case of a pronounced and persistent therapeutic effects of the defeat of nails, griseofulvin appointment should be combined with local therapy (as the same drug, and other antifungal agents) and in extremely difficult cases, may conduct the removal of the nail plate keratolytic agents.

Special instructions:

Griseofulvin affects the speed of decision making and speed of reaction, because the use of the drug requires giving up driving vehicles and the temporary cessation of activities requiring extreme psychomotor reactions. Griseofulvin therapy requires monitoring morphological blood picture   twice a month. If you have expressed allergic reactions, you must first have recourse to anti-allergic treatment, and then, in case of inefficiency, stop accepting griseofulvin for 4-5 days. Then you need to restart the drug, but the dose increased gradually and very carefully - to start with half a tablet, and slowly increased to therapeutic. In Pediatrics recommended Griseofulvin combined with a multivitamin complex.

Drug Interactions:

At the same time with the use of the drug Griseofulvin indirect anticoagulants   It leads to reduced activity of the latter. This is true for the reception of Oral forms of contraceptives   during therapy with griseofulvin. Barbiturates   weaken the antimycotic action of griseofulvin.