Description overdue on 28.04.2012

Antifungal . The active agent is a triazole derivative. Produced synthetically, it has a wide range of effects. Antifungal mechanism is based on suppression of synthesis ergosterol   in fungal cells. Active against fungi, dermatophytes, yeasts. The effectiveness of antifungal therapy evaluate a month after the completion of treatment (when mikozah). When onixomikozah effectiveness evaluated as the change of the nail plate (6-9 months). Itraconazole is available as a capsule solution.

Indications:

Itraconazole capsules are prescribed for pityriasis versicolor , Ringworm, keratomikozah, systemic fungal infections, oral candidiasis, vulvovaginal candidiasis, cryptococcosis , Systemic aspergillosis, gistaplazmoze, parakoktsidiodoze, sporotrichosis, blastomycosis, tropical mycoses. The solution of itraconazole is prescribed for esophageal candidiasis, oral candidiasis.

Contraindications:

Itraconazole is not appointed, while the application midozolama, triazolama.yu nisoldpina, ergot alkaloids, isoenzyme substrates SYR3A4, intolerance. The drug is not prescribed for breast-feeding during gestation pregnancy.

Side effect:

Itraconazole can cause allergic reactions, thrombocytopenia, serum disease, leukopenia, anaphylactoid reaction hypertriglyceridemia , Hypokalemia. Nervous system:   hypersthesia, paresthesia, dizziness, peripheral neuropathy .   Respiratory system:   pulmonary edema. The digestive tract:   diarrhea, dyspepsia, hepatotoxicity, increased hepatic enzyme system, vomiting, constipation , Hepatitis, breach of taste perception, hyperbilirubinemia, epigastric pain. Senses:   noise in the ears, the constant deafness, an illegibility of of visual perception, diplopia . Perhaps the development of arthralgia, myalgia , Urinary incontinence, pollakiuria, Erectile Dysfunction , Menstrual irregularities, swelling.

Mode of application:

Itraconazole is taken orally, the desired time of reception - after a meal. Vulvovaginal candidiasis: twice-a the day by 200 mg, either 3 of the day on 200 mg once per day. Dermatomycoses 7 days at 200 mg per day, 15 days or 100 mg 1 time per day. Chromophytosis 7 days of 200 mg daily. Candidiasis oral cavity: 15 days upon 100 mg daily. When mycosis skin plates on the hands antifungal therapy performed twice at an interval of three weeks. Elimination of the nail plate and the skin is slow. Systemic aspergillosis: 2-5 months 200 mg daily

Special instructions:

Prevention reinfection   It is simultaneously antifungal therapy of exposed sex partners, careful personal hygiene. Antifungal treatment involves abstinence from sexual activity during the entire course of therapy. If, after completion of antifungal therapy of disease symptoms persist, a second microbiological survey to validate the diagnosis. In severe neutropenia Itraconazole prescribed for ineffective first-line therapy. At detection of risk factors of CHF (expressed puffiness of, valvular heart disease , Ischemic heart disease, severe pulmonary pathology of COPD) antifungal therapy suspended. Application of an antifungal drug can cause deafness (transient and permanent form). When assigning preparation Itraconazole important to note that the drug solution contains sorbitol.

Drug Interactions:

Absorption   Itraconazole drug disrupted while the body is drugs that reduce gastric acidity. Phenytoin, rifampicin , Rifambutin and other inducers of the isoenzyme SYR3A4 impair the bioavailability of antifungal agent. Inhibitors of this enzyme have the opposite effect. When concomitant administration of BCCI, anticancer agents (trimetrexate, docetaxel, busulfan, vinca alkaloids) immunosuppressants   (sirolimus, tacrolimus), corticosteroids, digoxin, anticoagulants   care must be taken.