Description overdue on 28.11.2011

Antifungal agent. The main active ingredient is the current fluconazole . The drugs work by inhibiting the synthesis ergosterol   in cytomembranes micromycetes complexes. Mikomaks inhibits the action of a cofactor P450   in fungi, but not affects cells organism human. The bioavailability of the drug, regardless of dosage form is 90%. Mikomaks able to penetrate all tissues of the body and the environment, kidney system output unchanged. Available as a powder, syrup, solution, capsules and tablets.

Indications:

Mikomaks prescribed for the treatment, prevention of fungal lesions. The drug is effective in candidemia . disseminated candidiasis , Especially y patients taking immunosuppressants   and cytostatics   in cancer. Mikomaks prescribed for fungal infections of the mucous membranes: atrophic, oral candidiasis, esophageal candidiasis, oropharynx, tracheobronchial tree, the urinary tract. Fluconazole is used for acute and chronic candidiasis of genitals, ringworm   ( chromophytosis . athlete , Cutaneous candidiasis) cryptococcal infections   ( meningitis ).

Contraindications:

Mikomaks not prescribed for allergies to azole compounds simultaneous reception terfenadine, astemizole , Intolerance galactose . lactose . Mikomaks not appoint persons under the age of 16 years, pregnancy, breastfeeding.

Side effect:

The drug mikomaks can cause dyspepsia, diarrhea, flatulence , Epigastric pain, cutaneous exanthema , Headaches, allergic reaction. For intravenous administration of the drug at the injection site may develop phlebitis . The frequency of complications depends on the rate of introduction of fluconazole. In rare cases, develop thrombophlebitis . In cancer, AIDS, marked functional impairment in the renal system, alopecia, convulsions, deterioration of urinalysis (registered thrombocytopenia . lekykopeniya ). At insufficiency of hepatic system is possible development of heavy forms of of toxic hepatitis. If overdose is effective hemodialysis, forced diuresis .

Mode of application:

The oral form   mikomaks take medication after eating 1 time a day. Intravenous   carried out at a rate of no more than 10 ml per minute. One vial contains fluconazole dose for administration for one hour. Mikomaks compatible with the salt solution, glucose solution, sodium bicarbonate . After opening the bottle is not re-used, the product is destroyed. When switching from one formulation to another mikomaks change in dosage is required.

Special instructions:

The antifungal drug therapy mikomaks can begin to get information mycological examination . After receiving reliable results necessary to correct regimen. Therapy is conducted before the appearance of signs of clinical remission . Interrupting of said treatment course leads to relapses fungal infection. During treatment recommended to carry out analysis of indicators of of blood, the functional state of liver, kidneys. Hepatotoxic effects of the drug is reversible.

Drug Interactions:

Pelentan Warfarin and other coumarin anticoagulants increase prothrombin time . Mikomaks increases the half-life of oral hypoglycemic drugs, which are sulfonylureas   (tolbutamide, glibenclamide, chlorpropamide, glipizide). Fluconazole increases the level of phenytoin   in blood. Together with the admission rifampicin   it is recommended to increase the dosage mikomaks. The drug reduces the clearance theophylline . Cisapride, terfenadine lead to disruption of the heart (ventricular tachycardia paroxysm). Hydrochlorothiazide   increases the concentration of fluconazole. Mikomaks increases the concentration zidovudine .