Description overdue on 28.01.2012

Antifungal agent . Terbinafine - synthetic chemicals, allylamine derivative, has a pronounced antimycotic (as fungicidal and fungistatic) effect. Broad-spectrum effect has on many filamentous forms yeast   (in particular, fungi of the genus Candida), dermatophytes   (T. rubrum, Microsporum canis, T. verrucosum, Epidermophyton floccosum, T. Mentagrophytes, T. Violaceum), some dimorphic fungi (Pityrosporum orbiculare). Terbinafine operating principle is based on the fact that the drug is incorporated into the structure of the cytoplasmic membrane of the cell wall, inhibit squalene epoxidase (enzyme), resulting in an accumulation of the cell squalene Which causes the death of microorganisms. In addition to fungal cells inhibited ergosterol synthesis That reinforces fungicidal effect drug. Terbinafine is highly epidermo- and onihotropnostyu (i.e., its concentration in the skin and nail tissue exceeds the concentration in plasma after oral administration), good penetration into the skin stratum corneum, so that extremely effective in treating fungal skin pathologies and onychomycosis. Treatment of onychomycosis brushes terbinafine is effective in 95% of cases, the treatment of toenail onychomycosis, terbinafine is effective in 90% of cases. Terbinafine is produced in forms for topical application (spray, gel, cream), and oral (tablet form 250 mg).

Indications:

Terbinafine in the form of gel (or other release forms for external use - cream, spray) indicated in the treatment of diseases whose etiology is associated with fungal pathogens nature. This group of diseases get fungal infections of the skin, the scalp of the head, feet pathology, onychomycosis (fungal nail disease). Terbinafine is effective when athlete . pityriasis versicolor Caused by Pityrosporum orbiculare.

Contraindications:

Increased susceptibility to terbinafine, severe renal failure and liver parenchyma, blood pathology, cancer, endocrine diseases, including metabolic disease, a disease affecting the vascular bed. It is also a relative contraindication for the administration of the drug Terbinafine is pregnancy and when a woman breastfeeds. Terbinafine is not prescribed to children under two years of age.

Side effect:

Digestive system:   loss of appetite, cause nausea and vomiting, stool disorders, moderate or severe pain in the epigastric region. We can not exclude the occurrence of allergic reactions of the skin. Extremely rarely observed such syndromes as the skin lesions   erythema multiforme   and toxic epidermal necrolysis . While taking terbinafine may suffer Musculoskeletal system:   In this case, marked muscle pain, joint pain. Nervous system : Dizziness or headache. Hepatotoxicity Terbinafine may come back to haunt the emergence of dysfunction of liver parenchyma, from raising transaminases   before development cholestatic jaundice . It is possible oppression of the blood-forming organs, which will be the manifestation of thrombocytopenia and agranulocytosis , Lymphopenia. Finally, locally, at the site of application, the skin may be red, itchy can join.

Mode of application:

Terbinafine is a part of many drugs for the treatment of fungal infections of the skin. Forms for topical administration (gel, cream, spray) must be applied directly to the skin in the affected area is not more than twice a day, although in some cases, a single application Terbinafine. When the skin lesion is generalized, should be preferred spray. As a rule, the duration of the course of therapy with Terbinafine is about two weeks. In onihomikozah   there is a need for more long-term treatment, which is associated with the peculiarities of the nail plate and the pace of its growth. Displaying continued treatment with terbinafine and after the disappearance of symptoms of nail, up to the moment when the nail plate is completely upgraded. This may take up to twelve weeks. With this approach, Terbinafine is accumulated in the nail bed and stored by more than half, due to what is possible to achieve a reliable effect and avoid relapses. There are situations (with extensive lesions, with a high of symptoms) to local therapy makes sense to add Terbinafine in oral form. Tablets, each containing 250 mg of active ingredient, taken singly.

Special instructions:

If a patient has liver dysfunction or renal parenchyma dosage Terbinafine makes sense to review and reduce by half. Data for the fact that the use of Terbinafine in pregnant women can cause serious complications to the fetus is not, nor is there safety data terbinafine. From the use of Terbinafine in pregnancy is to abstain. The same is true with respect to nursing mothers. Overdose is unlikely, but possible, is shown   epigatsralnymi pain , Dyspepsia, headaches. Painful syndrome is accompanied by nausea and dizziness. No specific antidote is necessary to provide washing stomach, give the patient chelators. It is important to avoid contact with eyes terbinafine. After contact with the eyes should be rinsed thoroughly under running water.

Drug Interactions:

Since Terbinafine has some hepatotoxic , Assign it in conjunction with other hepatotoxic drugs is not necessary. You should also exclude alcohol during treatment. A number of drugs (including antidepressants   and contraceptives) that affect the metabolism of terbinafine, which requires correction of the dose of the latter (in the upward and downward dosage).