Description overdue on 04/21/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Cliona (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One tablet contains Cliona: metronidazole - 0 25 r + adjuvants (talc, corn starch, glycerol, magnesium srearat, colloidal silica, povidone ).

Product form

Packing with tablets of 10 pieces, 2 in a pack.

Pharmacological action

Antiprotozoal agent with an antimicrobial effect.

Pharmacodynamics and pharmacokinetics

Transport proteins anaerobes Inside the cell, is reduced 5 nitromidazol . The resulting material negative impact on the DNA   cells (interferes with the synthesis nucleic acid ). Microorganisms are killed.

Exhibit antimicrobial activity against gram-negative ( Trichomonas vaginalis, Bacteroides distasonis, Giardia intestinalis .   Prevotella ) And some Gram-positive bacteria (e.g. Peptococcus spp.   and Eubacterium spp.).

The drug is active against anaerobic organisms. On anaerobes are not affected. But with complex treatment antibiotics (eg amoxicillin ) Effectively destroys destructive microflora.

The drug may enhance separative processes and the degree of sensitivity of tumors to radiation ( tumors ).

Metronidazole   well absorbed, and about half of the substance is metabolized in many biological fluids. The maximum concentration achieved already within 2-3 hours after ingestion.

Indications

• gastric ulcer   or erosion Caused by the bacterium Helicobacter pylori ;
• condition after operations in the framework of prevention;
• trichomoniasis, giardiasis, cutaneous leishmaniasis, balantidiasis, amoebic liver abscess, amebiasis   and other protozoan infections;
• all kinds of diseases caused by Bacteroides, Peptostreptococcus , Clostridium, Peptococcus spp. ;
• colitis pseudomembranous;
• radiation therapy   patients with tumors.

Contraindications

• epilepsy   and other organic lesions in the central nervous system;
• liver and kidney disease;
• leukopenia ;
• drug allergy   Substances composed Cliona;
• pregnancy and breastfeeding.

Side effects

• pancreatitis , Lack of appetite, vomiting, nausea, metallic taste and dryness in the oral cavity, stomatitis;
• headache, dizziness, weakness, or on the contrary, excessive excitability, confusion, ataxia, hallucinations ;
• cystitis, urinary incontinence , The urine may become a reddish tint;
• leukopenia ;
• allergic reactions   on the skin, nasal congestion;
• candidiasis .

Instructions for use Cliona (method and dosage)

Tablets are taken orally after a meal or during drinking milk.

The duration of treatment and the dosage must appoint a physician. The maximum amount of the drug per day is 2 grams.

Instruction at trichomoniasis :

• from 18 - 0 5 g per day, in 2 divided doses for 10 days or 0, 8 grams per day, for two reception for one week or once every 2 g (patient and his partner);
• 10 years - 0, 5 g per day for 2 doses, 10 days;
• from 5 to 10 years - 0, 25-0, 35 g per day;
• from 2 to 5 years - 0 25 g per day.

At giardiasis :

• 18 years - 1 gram, 2 reception 5-7 days;
• aged 8 - 0 5 g, 2 reception;
• from 5 to 8 years - 0 375 grams per day;
• 3 years - 0 25 g per day for 2 receiving 5 days.

When serious violations of the liver or kidney disease daily dose should be reduced by 2 times.

Overdose

It may be nausea, ataxia, vomiting . Treatment - according to symptoms.

Cooperation

Not compatible with ethanol .

Enhances the action anticoagulants and lithium preparations .

Phenytoin, phenobarbital   and others Inductors of microsomal oxidation enzymes of the liver reduce the effectiveness of the drug.

Cimetidine   and sulfonamides Increase the level of concentration metronidazole   in blood plasma.

Terms of sale

It requires a prescription.

Storage conditions

The cool, dark place (15 to 25 degrees). Keep out of the reach of children.

Shelf life

5 years.

During pregnancy and lactation

If pregnancy does not apply the first trimester, with caution in the 2nd and 4th. Do not prescribed during lactation.

Reviews Cliona

Reviews Cliona differ. Some drugs effectively helps in the fight against trichomoniasis   and even candidiasis . Others complain of individual intolerance, severe itching and insomnia, and believe that the high efficiency of the means is not worth the sacrifice.

Price Cliona where to buy

The price for a tablet of 250 mg - 61 rubles per pack (20 pieces), the price in Ukraine - about 15 hryvnia for the same amount.