Description overdue on 17.11.2011

Antifungal drug. When applied topically, it has a wide range of actions. Main, an active substance is derived imidazole . Antifungal effect of clotrimazole is caused by a violation of the process of synthesizing ergosterol Which is part of the cell membrane of fungi. Under the action of the drug permeability of the membrane changes occur cell lysis . Small concentrations of the drug have fungistatic effect , Large - fungicide. Under the action of high concentrations of drug interaction occurs peroxidase and mitochondrial enzymes under the action of which increases the concentration of hydrogen peroxide is toxic to the rate at which the fungal cell dies. Clotrimazole acts on molds . dermatophytes, yeast fungus, the pathogen erythrasma, pathogen multi-colored lichen . The antimicrobial effect is against Trichomonas vaginalis, a Gram-positive (streptococci, staphylococci) and Gram (Gardnerella vaginalis, Bacteroides) flora. The drug does not cause systemic action is poorly absorbed through the mucous membranes, it does not penetrate the skin. Clotrimazole is available in the form of an ointment, cream, powder, solution for external application, and also in the form of vaginal tablets (candles), and lotions.

Indications:

Clotrimazole is used for fungal infections of the mucous membranes, skin: tinea, ringworm, athlete's foot, trichophytosis, candidiasis, microsporia, fungal interdigital erosion, stomatitis, fungal paronychia . The drug is effective in mycosis Complicated pyoderma . Vulvovaginal candidiasis , Vulva, trichomoniasis . balanitis , Erythrasma, pityriasis versicolor, pityriasis versicolor. Clotrimazole prescribed as a reorganization of the birth canal before the forthcoming birth.

Contraindications:

Candles Clotrimazole do not apply in the menstrual period. Clotrimazole is contraindicated in pregnancy (first trimester). Do not appoint breastfeeding.

Side effect:

Clotrimazole cream and ointment may cause local reactions: paresthesia , Peeling, irritation, burning sensation of the skin, edema . Blisters . Application forms vaginal causes swelling, congestion of the vaginal mucosa, burning, discharge, frequent urination, stomachalgia Pain during sexual intercourse, intercurrent cystitis .

Mode of application:

Clotrimazole applied topically. The solution, lotion, ointment and cream is applied with a thin layer on the affected skin three times a day, rub neat movements. In an area the size of a palm is consumed 10-20 drops of 5 mm or cream. The duration of treatment was about a month after the disappearance of clinical manifestations of the treatment was continued for another 2 weeks. Erythrasma   treated for -4 weeks pityriasis versicolor   - Up to 3 weeks. Clotrimazole cream is applied to clean skin, washed with soap and water and thoroughly dried. After the disappearance of the fungus from the skin of feet and legs, regular cream application was continued for another 3 weeks. Vaginal administered drug form deep into the vaginal cavity 5 grams once per day, 3 days treatment. With Candida balanitis   and vulvitis   Clotrimazole applied three times a day for 2 weeks. External genitals during treatment is recommended to treat vaginal forms solution, ointment or cream. Remediation of the birth canal is performed by introducing 1 tablet clotrimazole. With urethritis   perform instillation solution (1%) into the urethra, treatment for 6 days.

Special instructions:

To prevent reinfection to the simultaneous treatment of sexual partners. It is undesirable to use a vaginal applicator in pregnancy (2, 3 term). If trichomoniasis require combination therapy metronidazole . When applying the cream undesirable application of occlusive dressings. Avoid contact with eyes. In diseases of the liver system requires regular monitoring of its functional state. In the absence of the effect of clotrimazole treatment during the month recommended the re-confirmation of diagnosis.

Drug Interactions:

Natamycin . Nystatin . Amphotericin B   reduces the effectiveness of the drug clotrimazole.