Description overdue on 02.04.2012

Antifungal agent . The main component is fluconazole. The drug inhibits fungal enzymes that are dependent on the cytochrome P450. The drug is highly specific. It is based on blocking the process of converting lanosterol in ergosterol   fungal cells; to increase the permeability of the cell membrane, disrupting its replication and growth. Diflazon almost no inhibitory effects on cytochrome P450 in the human body, but highly selectively inhibits the enzyme in mushrooms. For fluconazole uncharacteristic antiadrogennaya activity. The drug is effective at opportunistic mycoses . Diflazon available in powder, capsule, solution, syrup, tablets.

Indications:

Diflazon prescribed for fungal infections of the systemic nature: sepsis , Meningitis, infections of the skin and lungs. The drug is prescribed to patients AIDS   for prophylaxis cryptococcal infection . The drug is effective for candidemia, a generalized form of candidiasis: disseminated candidiasis   involving the genitourinary system, eyes, respiratory, abdominal, endocarditis. Fluconazole is indicated for mucosal candidiasis: candiduria, bronchopulmonary candidiasis, esophageal, throat, mouth, atrophic,   Oral candidiasis . The drug is prescribed in the form of genital candidiasis: balanitis, vaginal candidiasis   (acute, recurrent forms). Diflazon prescribed for endemic mycosis, histoplasmosis, sporotrichosis, coccidioidomycosis, onychomycosis, skin mycosis.

Contraindications:

Diflazon not prescribed for alcoholism, breastfeeding, hypersensitive to fluconazole in pediatric practice, when carrying a pregnancy, kidney and liver pathology systems.

Side effect:

The digestive tract:   irregularities in the hepatic system disorders stool, loss of appetite, bloating, hyperbilirubinemia , Jaundice, ikterichnost sclera, elevated liver enzymes, epigastric pain. Bodies of blood: agranulocytosis , Neutropenia, petechiae, bleeding. Perhaps the development of the allergic response, toxic epidermal necrolysis, anaphylactic reactions, alopecia, disturbances in the renal system, hypokalemia, hypercholesterolemia .

Overdose:

Manifested hypertriglyceridemia, paranoid behavior , Hallucinations, increased severity of these side effects. It requires an extra holding of forced diuresis, gastric lavage. Thanks to 3 hours dialysis fails to reduce the drug concentration in half.

Mode of application:

Diflazon administered intravenously, is taken orally .  Infusion rate not greater than 20 mg per Minute .  When invasive Candida infections, disseminated candidiasis, candidemia, cryptococcal infections in the first day of the show receiving 400 mg fluconazole and then appoint 200-400 mg once daily .  The duration of antifungal therapy is determined by the mycological and clinical response .  AIDS patients for the prophylaxis of cryptococcal meningitis appoint 200 mg per day .  Oropharyngeal candidiasis requires the appointment of 50-100 mg flukonazaola 1 times a day, a course of treatment 7-10 days .  Patients with immunosuppression treatment is carried out for two weeks .  Oral, atrophic candidosis: within two weeks of taking daily 50 mg .  Vaginal candidiasis: inside, once 150mg .  Mycotic lesions feet, skin, inguinal folds: one time per week taking 150 mg, a once a day at 50 mg in 2-4 weeks .  Onychomycosis: once every seven days, 150 mg to a complete change of the nail plate .  Deep endemic mycoses: 200-400 mg daily for two years .

Special instructions:

Antifungal therapy is carried out prior to the registration counter of clinical, haematological remission. Discontinuation of treatment prematurely may trigger a relapse. Allowed prescribing Diflazon in the absence of culture results, but if any adjustment is required antifungal therapy. In the period of treatment required control functions of the liver, kidneys, blood indicators. In the case of disruptions of antifungal therapy is stopped. Hepatotoxic effects   fluconazole reversible held after the completion of treatment. Patients with   immunosuppression   may develop skin rashes, with the progression of symptom treatment ceased. When concomitant administration of coumarin anticoagulants   control prothrombin index .

Drug Interactions:

Diflazon increases the concentration of zidovudine, rifabutin , Cyclosporine, phenytoin, enhances the efficiency of coumarin anticoagulants. Fluconazole is able to prolong the half-life theophylline , Increasing the risk of intoxication that require dose adjustment. The simultaneous use of sulfonylureas (tolbutamide, chlorpropamide, glipizide, glyburide) requires control of blood sugar levels, and, if necessary, an adjustment is required doses hypoglycemic agents. Under the influence hydrochlorothiazide   fluconazole concentration rises in the blood plasma by 40%. In the appointment of cisapride, terfenadine increased risk of arrhythmia, paroxysmal Ventricular tachycardia .