Description overdue on 25.01.2012

Antifungal agent . The active ingredient is a highly selective inhibitor of the processes for the synthesis of sterols in fungal cells - fluconazole. Diflucan is effective against yeasts , against yeasts And also against molds . Preparation Diflucan perfectly absorbed in the digestive tract and showed good oral bioavailability: the concentration of drug in blood when taken in tablet form was more than 91% of the substance in the plasma after intravenous injection. Eating in no way affect the bioavailability of Diflucan, and the maximum plasma concentration is reached within 30-90 minutes. The half-life of 30 hours, last day of the drug action. Diflucan well into the skin, organs, tissues, including cerebrospinal fluid The secret of the mucous membranes and saliva. High concentrations of fluconazole (higher than in blood plasma) was observed in the skin (stratum corneum) in the sweat glands. In unaltered from the body excreted by the kidneys. Available as a powder, a syrup, capsule, tablet.

Indications:

Diflucan is prescribed for fungal porazheniyach sexual sphere of women, known as Vaginal candidiasis . The drug is effective in all kinds of fungal infections caused by Candida fungus   (candidiasis). This pathology can be caused by immunosuppressive therapy , Long-term use of antibiotics, immunocompromised , Including HIV infection. Perhaps the use of Diflucan and prophylactically. Others indications for the drug Diflucan are cryptococcosis   (including cryptococcal meningitis ), Mycotic lesions of the skin, fungal infection of the nail plate (onychomycosis).

Contraindications:

Diflucan is not appointed, while the use of terfenadine, cisapride. No tests were carried out and there is no data on the safety of fluconazole during pregnancy and lactation, and although this should be considered a relative contraindication to appoint Diflucan pregnant women should be cautious. The intolerance of fluconazole is also a contraindication to administration of the drug.

Side effect:

In most cases, the drug Diflucan is not accompanied by side effects, however, a violation of the internal organs are possible. Nervous system:   there may be headaches, accompanied vertigo Possible increased muscle excitability and convulsions.   The skin can react to receiving Diflucan allergic reactions, possibly even the development of complications such as the malignant erythema   (referred to as a complication of Stevens-Johnson syndrome), which manifests the appearance of painful blisters on the mucous membranes and skin. Cases of severe complications such as the Lyell's syndrome : On the skin appear bullous elements which develop necrotic processes.   Digestive tract : Epigastric pain, changes in laboratory parameters of liver function, addition of toxic hepatitis, indigestion, vomiting, nausea. From the heart   It may be changes in conductivity, which are reflected on the ECG. The blood may occur reduction of platelet   agranulocytosis   and lymphopenia. Allergic reactions may reach the maximum degree of severity (anaphylactic shock).

Mode of application:

Diflucan sold in capsule form, the dosage is 150 mg, 100 mg and 50 mg. The solutions for intravenous administration - 100 mg and 200 mg in bottles of 50 ml and 100 ml. The dose of 150 mg is effective daily, taken with meals. For the treatment of fungal infections of the majority is enough to take 150 mg single dose of Diflucan. So when vaginal candidiasis women once is enough to take one tablet of the drug Diflucan, but in chronic course of the drug should be taken at the same dosage once every month. For the prevention of this condition is shown Diflucan at the same dosage. In a number of fungal infections the dosage can be increased to 400 mg, and a course of treatment is extended to four weeks.

Special instructions:

It is noted for severe toxic hepatitis while taking Diflucan, because during therapy need to carefully monitor the level of liver enzymes. Especially in patients with a history of liver disease, there are systems, and if the function of the liver cells is broken. Such patients strictly forbidden to self-medicate and take Diflucan without first consulting with a specialist. Toxic hepatitis caused by taking Diflucan, can be fatal. Necrotic skin lesions (Lyell's syndrome), as a rule, have been associated with severe disease of the immune system (AIDS). In patients with cardiovascular diseases and related disorders electrolyte balance   should take the drug with caution, as high risk for arrhythmias. During pregnancy and lactation Diflucan is prescribed only for health reasons, as there is no evidence that the drug is safe and has no effect on the fetus terratogennoe.

Drug Interactions:

Diflucan in combination with oral contraceptives increase the content of the latter in the blood.   Rifampicin   Diflucan accelerates clearance from the blood plasma, which requires correction dose of fluconazole upward. In turn, increases in blood Diflucan content Theophylline That require dosage reduction while taking the last. Terfenadine   Diflucan and can affect the electrical activity of the heart, ECG changes, broken cardiac rhythm . Possibly fatal, because the use of these drugs at the same time is possible only when the dosage of Diflucan does not exceed 400 mg. All the above is true of terfenadine with respect to Cisapride . Diflucan can change the content in the blood Cyclosporine Because at the same time taking hold once recommended level last control study in blood plasma. Diflucan increases the concentration Benzodiazepines That leads to psychomotor reactions. A combined intake of Diflucan and drugs that affect blood clotting time, can be fraught with increase in clotting time and the appearance of bleeding. Hydrochlorothiazide   reduces the excretion of Diflucan and increases its concentration in blood is 40%.