Description overdue on 04/06/2013

Antifungal . The main component is a synthetic triazole derivative. Itraconazole   It has a broad spectrum of effects. The medicament is active against fungi, dermatophytes , Yeasts. Evaluating the effectiveness of antifungal therapy is possible only after 2-4 weeks after completion of treatment. In onihomikozah effectiveness assessed after full change of the nail plate. Kanditral available in capsule form, as well as a solution.

Indications:

Kanditral multicolored capsules prescribed for herpes, Vulvovaginal candidiasis , Onychomycosis, candidosis oral mucosal wall, with keratomikoze , Cryptococcosis, systemic candidiasis, aspergillosis sistemnoi, cryptococcosis of the central nervous system, in cryptococcal meningitis in immunocompromised patients, with paracoccidioidomycosis, sporotrichosis, blastomycosis, gistaplazmoze, tropical mycoses, systemic fungal infections. Instructions for use are encouraged to nominate Kanditral as a solution with the ineffectiveness of first-line therapy in patients who have undergone bone marrow transplantation, as well as suffering from leukemia for the prevention of deep forms of mycosis. The drug is prescribed for candidiasis of the mucous walls of the esophagus and oral cavity in HIV-infected patients and imunnokompromitirovannyh.

Contraindications:

Kanditral not prescribed for the individual hypersensitive to itraconazole, when chronic heart failure , While cisapride therapy, bepridilom, astemizole, quinidine, pimozide, mizolastine, levatsetilmetadolom, sertindole, pimozide, terfenadine and other subtratami isoenzyme SYR3A4 that can prolong the QT interval on an electrocardiogram. The drug is not prescribed for carrying a pregnancy, simultaneous administration of midazolam, simvastatin, lovastatin, HMG-CoA reductase eletriptina, nisoldipine, ergot alkaloids (metilergotamin, ergotamine, ergometrine, dinidroergometrin) and breastfeeding.

Side effect:

Bodies of blood: thrombocytopenia , Leukopenia, neutropenia rarely recorded. Metabolism: hypertriglyceridemia , Hypokalemia. Nervous system:   hypersthesia, headache, dizziness, peripheral neuropathy, a form, paresthesia . Senses:   permanent or transient form of deafness, disturbances of visual perception in the form diplopia   or bleeding, ringing in the ears. Cardiovascular system:   congestive heart failure. Respiratory system:   edema of the lung tissue. The digestive tract:   diarrheal syndrome, epigastric pain, nausea, vomiting, hepatitis, constipation, dyspeptic symptoms , Acute liver failure, hyperbilirubinemia, hepatotoxicity, disturbances of appetite and taste perception. Perhaps the development of an allergic response in the form angioedema , Serum sickness, hypersensitivity reactions, anaphylactoid and anaphylactic reactions. Skin:   epidermal necrolysis (toxic form), itching, skin rashes, the formation of Stevens-Johnson syndrome, photosensitization , Leykoplastichseky vasculitis exfoliative dermatitis , Erythema multiforme, alopecia, rash. Musculoskeletal system: arthralgia , Myalgia. Urogenital: erectile dysfunction , Menstrual disorders, urinary incontinence , Pollakiuria. Rarely swelling recorded on the background of treatment Kanditral.

Mode of application:

Kanditral taken orally, the capsule must be swallowed whole, preferably immediately after a meal. Treatment of vulvovaginal candidiasis:   twice daily 200 mg in a single day; the second treatment regimen is designed for three days, to be taken daily 200 mg Kanditrala. Treatment dermatomycoses:   during the week to take a daily 200 mg or within two weeks of taking 100 mg daily. Treatment of tinea hands, feet and other skin lesions vysokokeratinizirovannyh sites:   during the week to take a daily 200 mg Kanditrala or within 30 days of 100mg. Treatment for tinea versicolor:   take a daily 200 mg itraconazole, the course is designed for a week. Treatment of mucosal candidiasis oral cavity:   within 15 days take a daily 100 mg of the drug.   Treatment keratomikozov:   21 days daily intake of 200 mg (depending on the clinical response to determine the duration of therapy). Treatment of onychomycosis:   within 3 months of taking 200 mg either during the week taking 200 mg twice daily.

Special instructions:

Upon completion of the course of antifungal therapy while maintaining the clinical symptoms of the underlying disease requires repeated microbiological examination to identify the causative agent, confirm the diagnosis, selection of treatment regimens. Prevention reinfection   antifungal therapy achieved simultaneous sexual partners. It is recommended to comply with all rules of hygiene, and sexual abstinence. In severe neutropenia   Kanditral efficacy is unknown, so the drug is recommended to be prescribed only in the case of the ineffectiveness of the first-line therapy. In the case of the various risk factors of chronic heart failure (heart valve lesions, the formation of coronary artery disease, severe pulmonary pathology of COPD, as well as the state, accompanied by edema syndrome) Kanditral overturned. Responses to the drug Kanditral indicate a high efficiency of the medicament in the antifungal therapy, good tolerability (rarely recorded permanent and transient deafness ). Patients with congenital fructose intolerance, be aware that the medication contains sorbitol. Analogs Kanditrala: Irunine, Itrazol, Orungal, Mikonihol, Itramikol, Orun, Teknazol, Rumikoz . Buy Kanditral at any pharmacy chain (medical prescription form show optional). Kanditral price varies depending on the release forms, the pharmacy (the average price - 500 rubles).

Drug Interactions:

Medicines, which reduces the effect of gastric acidity, can disrupt the absorption Kanditrala. Phenytoin, rifabutin, rifampicin and other inducers of the isoenzyme SYR3A4 have a negative impact on the bioavailability of the drug . Clarithromycin, ritonavir, erythromycin, and others indinafir SYR3A4 isoenzyme inhibitors increase the bioavailability of itraconazole. We recommend caution when concurrent therapy HIV protease inhibitors, indirect anticoagulants , BCCI (verapamil, dihydropyridines), certain anti-cancer agents (vinca alkaloids, trimetrexate, docetaxel, busulfan), some immunosuppressive (sirolimus, tacrolimus, cyclosporine), some corticosteroids (methylprednisolone, fluticasone, dexamethasone, budesonide), digoxin, loperamide, reboxetine, carbamazepine, disopyramide, cilostazol, ebastanom, rifabutin, midazolam, brotizolamom, halofantrine, fentanyl, repaglinide.