Description overdue on 04/08/2013

Antifungal agents.   The drug is administered orally and topically. The active component acts terbinafine . Low concentrations of medicament having fungicidal effects   against fungi, and   dermatophytes . Activity fungistatic or fungicidal effect is manifested in the medicament according to the type of fungus. Tablets Lamikan no effect on the hormonal metabolism of other drugs. The principle is based on feedback active substance inhibiting squalene epoxidase in the fungal cell membrane (not applicable to the system Cytochrome P450 ) For suppressing a specific process for synthesizing sterols   Early in fungal cells. This results in a deficit ergosterol , Accumulates intracellularly squalene That leads to the death of the fungal cells. The drug is available in tablet dosage form, as well as a gel, ointment, spray, rasvora.

Indications:

Lamikan prescribed for fungal infections of the nail plate and the skin   (candidiasis of the mucous membranes and skin, rubrofitii, microsporia , Trichophytosis, athlete's foot), with multi-colored shingles (topical treatment). In the treatment of onychomycosis are applied only local Lamikan drug dosage forms.

Contraindications:

Instructions for use of the drug is not recommended for Lamikan medication intolerance terbinafine, children under two years old, for women during lactation and during the child bearing. At suppression of bone marrow hematopoiesis Under occlusive vascular diseases, with metabolic disturbances and the presence of tumors of various tumors, alcoholism, severe liver disease and kidney terbinafine used with caution.

Side effect:

In drug treatment, marked Lamikan musculoskeletal reaction of myalgia and arthralgia, allergic skin responses (rash, urticaria) dyspepsia (epigastric pain, a feeling of fullness, nausea, eating disorders). Rarely observed violation of taste perception, hepatobiliary changes in the form cholestatic jaundice , Neutropenia, erythema multiforme, anaphylactoid reactions , Redness of the skin in the area of ​​application.

Overdose:

Manifested dizziness, stomachalgia , Headaches. Assign an activated carbon, a supportive posindromnuyu therapy.

Mode of application:

Tablets Lamikan taken after a meal twice a day at 0, 125 g or 1 times daily at a dose of 0, 25 grams. The course of treatment is on average 1-2 weeks. In severe kidney disease the amount of medication reduced by half. Duration of therapy in tinea is 2-6 weeks (the defeat soles, interdigital spaces), 2-4 weeks (defeat shins). At fungal infections of the scalp Lamikan administered 4 weeks. Toenail onychomycosis   - 12 weeks of treatment, onychomycosis brushes - 6 weeks. In some cases, antifungal therapy is performed over the entire period the change of the nail plate. The ointment and cream Lamikan applied thinly, lightly rubbing the affected area. Before using the spray solution or affected areas are pre-treated, cleaned and dried.

Special instructions:

Price depends on Lamikan pharmacy network. Early completion of therapy, irregular use of medication, as well as failure to comply with all the requirements and recommendations can lead to relapse of fungal diseases. After two weeks of therapy requires an assessment of the effectiveness of the drug. In the absence of positive dynamics registration required re-determination of the pathogen, and evaluation of its sensitivity to terbinafine. Before the course of treatment required blood test   and determining the level of liver enzymes system. During registration jaundice Resistant nausea, eating disorders, excessive fatigue and dark urine conducting a survey of the liver, treatment should be stopped. Be sure to antifungal treatment stockings, shoes and socks during the entire course of therapy with Lamikan. Unacceptable ingress of medicament to the eye mucosa, the oral or nasal cavity. Buy Lamikan possible in Pharmacy. Not require a doctor's prescription form.

Drug Interactions:

Lamikan able to reduce clearance   caffeine 20 percent. Drugs that inhibit hepatic microsomal enzymes which reduce the clearance antifungal agent, and drugs that induce these enzymes increased clearance. Hepatotoxic medications, ethanol Lamikana enhance the toxic effect on the liver.