Description overdue on 16.01.2012

Antifungal drug.   Main, an active substance - terbinafine Refers to a group of allylamines, it has a wide spectrum of action, used for topical application (spray Lamisil cream, gel) or oral (Lamisil tablets of 250 mg). Terbinafine in small concentrations exhibits fungicidal effect against dermatophytes   (Trychophyton rubrum, Epidermophyton floccosum, Microsporum canis, etc.), And a number of dimorphic mold (Pityrosporum orbiculare) mushrooms. With respect to the yeast fungus terbinafine can have both fungicidal and fungistatic. Lamisil selectively acts on the early stage of the synthesis of a number of sterol in fungi, which leads to inhibition of development ergosterol   and cell death of the fungus. Another way to impact the drug Lamisil - inhibition of an enzyme known as squalene epoxidase . This enzyme is located in the cell membrane, and suppression of its leads to the accumulation of intracellular squalene, causing its destruction. The ratio of the cells of the human body like Lamisil no effect on the metabolism is not affected. Lamisil cream is applied only topically on the skin is absorbed no more than 5% of the drug, and the effect of the topical application occurs relatively quickly - within 3-4 days, a full course of treatment is rarely lasts for more than 4 weeks.

Indications:

Lamisil gel, cream, spray indicated for the treatment of diseases caused by a fungal pathogen nature. This group of diseases such as fungal infections (affecting the skin, scalp, tinea pedis) and onychomycosis (nail plates and damage the nail bed). Lamisil Cream is effective and jock itch , Skin infections caused by yeasts, including the genus Candida. Another indication for Lamisil is pityriasis versicolor , Caused by a fungus such as the Pityrosporum orbiculare.

Contraindications:

The only absolute contraindication for prescribing Lamisil is increased sensitivity, intolerance to the active ingredient terbinafine or inactive auxiliary components that are part of Lamisil. Relative contraindication in which to appoint Lamisil cream should be cautious, are diseases associated with hepatic or renal insufficiency. It is also worth to be alert if the patient has bone marrow suppression, diseases associated with metabolic disorders, oncological diseases . There is insufficient data on the safety of terbinafine for children is not recommended until the age of 12.

Side effect:

Lamisil is well tolerated in most cases, no adverse effects were observed. However, the appointment of Lamisil still possible reddening of the skin in the area of ​​application, a little itchy. It may also appear rash Accompanied by a burning sensation. When the symptoms persist, it makes sense to interrupt therapy. If the system can be applied in extremely rare cases, there are disorders of the digestive tract, such as nausea and vomiting, decreased liver function and increase in the blood concentration liver enzymes .

Mode of application:

Lamisil ointment is recommended to apply in the affected area, it should be applied no more than twice a day, but often enough, and a single application of the drug .  In some cases, skin lesions can be generalized, and the area of ​​the affected area is too large to be applied Lamisil cream .  In this case, it is recommended to apply Lamisil Spray .  Among the general recommendations are the following fundamental provisions: the affected area before applying Lamisil should be clean and dry, apply the cream in a small amount, a thin layer of Lamisil spray sprayed to wetting the affected area and the adjacent healthy skin .  Adjustments to the dosage depending on the age is not required .  The course of treatment - up to two weeks .  More long-term therapy is required when onihomikozah .  In this case, treatment is extended to fully update a nail plate, which may require, and 12 weeks .  After such a long course of further active substance is stored in the nail bed more than six months, to achieve a stable effect and prevent relapse .  In some cases (extensive damage, high severity of symptoms) to local therapy makes sense to add the application and the oral form of the drug in order to achieve a generalized effect .  Lamisil tablets is available in 250 mg, taken once a day 1 .

Special instructions:

Lamisil Spray is not for use on the face .  If substance has got into the eyes should be washed with water .  The caution should be applied in the preparation of areas of the skin where there is pronounced inflammatory response .  There are no data on the safety of terbinafine in pregnant women, because in this case the need to prescribe a drug only if the potential benefit from it at times outweighs the potential risk .  Solve it must physician .  When breastfeeding is not recommended to use Lamisil, and if necessary, is not a time to stop breastfeeding .  Lamisil not affect the speed of psychomotor reactions, because its use is not subject to restrictions for drivers, dispatchers and other professions that require high concentration and lightning fast response .  Overdosing is virtually impossible, but the appearance of side effects described above (nausea, etc. . d . ) Need to wash out the stomach and take sorbents .

Drug Interactions:

Do not appoint Lamisil with drugs have toxic effects on the liver. It is strictly forbidden to consume alcoholic beverages during treatment. Some drugs ( antidepressants . Contraceptives ) May affect the metabolism of Lamisil that require dose adjustment of the latter.