Description overdue on 27.05.2012

Antifungal agent . The main component - ketoconazole . The drug has antimycotic effect against dimorphic fungi . The drug is active against dermatophytes, eumitsetov and yeasts . Notes the effect of the drug on the Nizoral streptococcal and staphylococcal flora. The principle effects of ketoconazole is aimed at synthesizing process in violation of the fungal cell ergosterol . Nizoral inhibits the transition to the invasive form of blastospores Candida albicans. Nizoral produced in the form of tablets, shampoos, lotions, suppositories, ointments.

Indications, contraindications:

Nizoral is prescribed for fungal infections:   onychomycosis, epidermomycosis , Epidemorfitiya feet and hands, jock itch Folliculitis, chromophytosis , Skin candidiasis, ringworm smooth skin, seborrheic dermatitis . Nizoral shampoo is prescribed for mycosis of the scalp, with Dandruff , Seborrheic dermatitis, mold mycoses, pityriasis versicolor. Nizoral is not indicated in case of intolerance ketoconazole, breastfeeding, pregnancy. Nizoral tablets prescribed with caution while taking hepatotoxic drugs, pathology of renal, liver disease, alcoholism, children up to 2 years, hypochlorhydria   and achlorhydria.

Side effect:

Urinary system:   azoospermia, impotency, dysmenorrhea , Oligospermia, gynecomastia   and decreased libido in males. Nervous system: paresthesia , Dizziness, headache, increased drowsiness. The digestive tract:   toxic hepatitis, hypercreatininemia , Increased liver enzymes, disorders of stool, pain in the epigastric area, disturbances of appetite, nausea and vomiting. Perhaps the development of photophobia, rash, fever, skin rashes, hives and other allergic reactions. Rarely observed alopecia. Nizoral shampoo can cause hair loss, irritation of the skin of the scalp, the change in pH.

Mode of application:

Nizoral shampoo is used topically .  When seborrheic dermatitis cream is applied for 2-4 weeks, daily 2 times a day .  Shampoo nenaosyat in a small amount on the affected skin fungus, hold for 3-5 minutes, and washed thoroughly with water under .  When mold mycosis drug treated hair and skin for 5 days, 1 time per day .  From prevention to drug use 3 days .  Nizoral cream is treated with a fungus affected skin two centimeters of healthy skin .  Antifungal therapy is conducted within 3 days after the disappearance of all signs of the disease .  The duration of treatment of mold and fungal infections candidiasis is 2-3 weeks, jock itch - 2-4 weeks, tinea versicolor - 2-3 weeks, tinea - 2-6 weeks .  For the prevention of seborrheic dermatitis Nizoral shimpun used 1 time per week every 2 weeks for the treatment uses 2% shampoo twice a week course of therapy 2-4 weeks .  Pityriasis versicolor treated by applying 2% shampoo using the applications to the affected areas by a fungus, with capture binding to healthy tissues, left for 5 minutes, then thoroughly rinsed .  Nizoral tablets taken with meals .  Treatment of multi-colored lichen and dermatomycoses: 1-8 weeks to take daily 200-400 mg of ketoconazole .  Treatment of onychomycosis lasts 3-12 months of daily administration of 200-400 grams .  Nizoral tablets administered under the supervision of the state of peripheral blood .

Special instructions:

Nizoral drug therapy is required mandatory review of the state of the renal system and liver. If treatment of fungal skin lesions began to use glucocorticosteroids , The Nizoral prescribed in 2 weeks. In patients with hypochlorhydria and achlorhydria ketoconazole may be ineffective because of the lowered ground absorbability of the drug substance. Upon receipt of acidic beverages Nizoral absorption increases. Can not allow any of ketoconazole in the eye. If necessary, long-term combination therapy and glucocorticosteroids Nizoral ketoconazole encouraged to nominate in the evening, and steroids in the morning for the prevention syndrome "cancel". Within 2-3 weeks of steroids gradually overturned. Reliable data on the efficacy and safety of the drug in children there.

Drug Interactions:

Appointment hepatotoxic medications   and ethanol can cause damage to liver parenchyma. Drinking alcoholic beverages is disulfiramopodobnye reaction . Under the influence isoniazid   and rifampicin   Nizoral decreased concentration in the blood. The drug increases the bioavailability of the drug indinavir. Nizoral may provoke an attack of hypoglycemia, increase the level of sulfonylureas. Ketoconazole reduces the efficacy of amphotericin B. Under the influence of the drug reduced stimulating effect on the tissue of the adrenal corticotropin. In appointing astemizole, terdenadina, cisapride significantly increases the risk of severe cases Ventricular tachycardia   the type of "feasting".