Description overdue on 23.01.2012

Antifungal . Main, an active substance - itraconazole . The mechanism of action of the drug is based on the inhibition of synthesis ergosterol   in the cell membrane of fungi. The drug is active against yeasts Sandida, dermatophytes , Mold fungi. When mycosis Treatment efficacy was assessed one month after treatment. At onihomikozah   the effectiveness is judged as the change of nail plates in 9 months. Orungal available as a solution for oral administration, capsules.

Indications and contraindications:

Orungal prescribed for fungal infections of the skin, eyes, mouth, when trophic mycosis . systemic aspergillosis , Onychomycosis (yeast, dermatophyte) cryptococcosis . candidiasis . pityriasis versicolor . blastomycosis , Paracoccidioidomycosis, sporotrichosis, histoplasmosis . Orungal not apply in case of intolerance itraconazole, breastfeeding, pregnancy. The elderly, with cirrhosis , Heart failure, chronic renal failure in pediatric and used with caution.

Side effect:

Digestive system : Cholestatic jaundice, hepatitis, increased liver enzymes, constipation . diarrhea , Loss of appetite, epigastric pain, dyspepsia. Nervous system : peripheral neuropathy , Dizziness, headaches. Perhaps the development of hypokalemia, dysmenorrhea . alopecia . exudative erythema multiforme , Edema syndrome, fatigue, angioedema , Hypercreatininemia, staining of urine a dark color.

Mode of application:

Capsules Orungal swallow completely, preferably after a meal. Vulvovaginal candidiasis : Twice a day, 200 mg, 3 days treatment.   Chromophytosis : Therapy lasts for a week, you should take a daily 200 mg. Dermatomycoses : 2 week course of therapy, daily 100mg.   Oral candidiasis : 15 days of therapy, daily 100mg. Fungous keratitis : 21 day course of therapy at 200 mg daily.   Onychomycosis : 3 months treatment at 200 mg per day. Systemic candidiasis : Treatment to 7 months, 100-200 mg daily. Systemic cryptococcosis : 200 mg daily. Cryptococcal meningitis : Twice a day at 200 mg. Sporotrichosis : 3 month course of therapy at 100 mg daily.   Blastomycosis:   treatment lasts six months, 100-200 mg daily.

Special instructions:

Persons with neutropenia After organ transplantation, AIDS sufferers requiring higher doses of the drug Orungal. Long-term therapy (more than 1 month) requires monitoring of the state of the hepatic system. Women of childbearing age during treatment is not recommended to plan pregnancy. With the development of Peripheral neuropathy , Disturbances of the liver of the drug overturned.

Drug Interactions:

Orungal extends and enhances the effect of drugs in the metabolism of the active participation of   Cytochrome P450 : Vincristine, tacrolimus, quinidine, dihydropyridine, methylprednisolone, digoxin Cyclosporin A, indirect anticoagulants, triazolam, midazolam, cisapride, astemizole, terfenadine. When taken with isoenzyme inhibitors SYR3A4 ( clarithromycin Indinavir, ritonavir) increases bioavailability. Phenytoin, isoniazid   all Inductors of microsomal oxidation   in the liver reduce bioavailability. Sucralfate, omeprazole , M-holinoblokatory, antacids and Orungal recommended to be taken with an interval of at least two hours. Cisapride   increases the risk of ventricular arrhythmias, significantly enhances the toxicity.