Description overdue on 05/13/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One capsule formulation contain 50, 100 or 150 mg fluconazole .

Product form

Vero Fluconazole is available in bezgyachakova contour package of 10 capsules. The carton contains one package.

Pharmacological action

The drug has antifungal activity .

Pharmacodynamics and pharmacokinetics

Vero Fluconazole is an antifungal agent derived triazole . Selective inhibitor of the synthesis of sterols in the fungal cell.

Fluconazole exhibits high activity for opportunistic fungal infections that can be caused by including Candida spp. ; endemic mycoses caused Histoplasma capsulatum . Coccidioides immitis . Blastomyces dermatitidis ; Cryptococcus neoformans   (including intracranial infection) Trychoptyton spp. . Microsporum spp .

If any reception methods (oral or intravenous), Fluconazole similar pharmacokinetics.

Is well absorbed, total bioavailability and blood levels - greater than 90%. At intake on the absorption of food intake is not affected. The maximum concentration observed after 1, 5 hours (when fasted). The concentration of the substance in the blood is proportional to the dose.

Excreted through the kidneys. About 80% of the dose is excreted unchanged in the urine.

Indications

Vero Fluconazole should be taken in such cases:

• cryptococcosis   (including also cryptococcal meningitis);
• candidiasis   (dissemenirovanny, mucosal, vaginal, skin, oropharyngeal, nails, Generalized);
• prevention of candidiasis;
• candidemia .

Contraindications

The drug is banned in the following cases:

• pregnancy;
• sensitivity to fluconazole;
• lactation;
• reception cisapride ;
• reception terfenadine   (in case of receiving 0, 4 g / d or more fluconazole);
• sensitivity azole derivative Having a structure similar to fluconazole.

Side effects

Taking medication can lead to the appearance of the following effects:

• change of taste, dizziness, headaches, cramps;
• flatulence , Vomiting, hepatocellular necrosis, diarrhea , Nausea, jaundice,   abdominal pain, liver function abnormalities, liver toxicity, dyspepsia Increase levels of bilirubin, serum transaminases, alkaline phosphatase;
• ventricular fibrillation . ventricular flutter ;
• alopecia , Stevens-Johnson syndrome, rash, toxic epidermal necrolysis, exfoliative skin conditions;
• leukopenia   (including agranulocytosis . neutropenia ) thrombocytopenia ;
• hypokalemia , Increased levels of triglycerides and cholesterol in the blood;
• anaphylactic reactions (e.g. angioedema , Swelling of the face, hives Itching).

Instructions for use (method and dosage)

The drug is taken orally or administered intravenously. The dosage regimen set individually for each patient.

Daily dose for adults   It is in the range of 50-400 mg for children   - 3-12 mg / kg. Take once a day.

The dose for patients with impaired renal function should be reduced.

The duration of therapy depends on the speed of manifestation mycological and clinical response.

Overdose

Data on symptoms of overdose is not granted.

Cooperation

Concomitant use of fluconazole with warfarin can cause bleeding ( melena . hematoma . hematuria , Bleeding from the gastrointestinal tract, nose).

Patients taking these drugs and benzodiapenin   We should reduce the dose of receiving the latter.

In combination cisapride   fluconazole and can lead to heart reactions (such as arrhythmia ).

The drug enhances the effect of the reception anticoagulants . cyclosporine . hydrochlorothiazide . zidovudine , Preparations sulfonylureas . phenytoin . theophylline .

Combination with astemiazidom   or terfenadine   forbidden.

Terms of sale

In pharmacies, the drug is sold by prescription.

Storage conditions

Store in a dry, dark place at room temperature (to above 25 ° C).

Shelf life

Keep 3 years.

Cautions

Care must be taken during the course of therapy in the presence of liver dysfunction When they appear rash   patients with fungal infections in patients with potentially   proarrhythmic state .

Perhaps manifestations hepatotoxicity   Fluconazole, which is reversible and ends when the abolition of therapy.

During pregnancy and lactation

Security Research Vero fluconazole pregnant women were not conducted.

At the time of treatment must use contraceptives.

Fluconazole has the properties to concentrate in breast milk, so its intake during lactation is not recommended.

Reviews

Testimonials mostly positive, many note the rapid and effective action of the drug.

Price Vero fluconazole, where to buy

The average price of facilities is about 40 rubles.