Description overdue on 05/07/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use chlorhexidine digluconate (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition Chlorhexidine

The preparation 0, 05% solution   Chlorhexidine digluconate include 0, 5 mg chlorhexidine bigluconate , Additional substances.

The preparation 20% solution   Chlorhexidine digluconate include 0, 2 g of active ingredient, additional substances.

Product form

INN: Chlorhexidine (Shlorhexidine)

Form release agents next. The drug is available as a solution of 0, 05% for use externally. In the bottle with a nozzle of a polymer, as well as in glass bottles of 100 ml, 1 vial of packaging cardboard.

A solution of 20% of the drug sold in plastic bottles with cap, 100ml, 500ml.

Available as candles, gel (it includes Lidocaine ), Cream, ointment, spray with the same active ingredient.

Pharmacological action

The aqueous solution of chlorhexidine digluconate has a local antiseptic, mainly bactericidal. Means - a derivative dihlorsoderzhaschee biguanide . Effects on the body, altering the properties of the cell membrane of microorganisms. Cations that formed as a result of dissociation of salts of chlorhexidine, reacted with bacterial membranes, which are negatively charged. Effect of the drug contributes to the destruction of the cytoplasmic membrane of bacteria. Her balance is disturbed and the bacteria eventually die.

Chlorhexidine digluconate 0, 05%, 20% gluconate effectively destroys a number of strains of microorganisms. It Neisseria gonorrhoeae . Trichomonas vaginalis . Bacteroides fragilis . Chlamidia spp ., Gardnerella vaginalis . Treponema pallidum . Also, the drug activity toward Ureaplasma spp . And also has the effect of moderate activity against the specific strains Proteus spp. and   Pseudomonas spp .

To demonstrate the drug resistant virus (exception - a virus Herpes ), Fungal spores.

If rinse with Shlorhexidinum used for washing hands or skin are treated drug, chlorhexidine digluconate has prolonged antibacterial influence. Therefore, the preparation can be used for the treatment of hands of the surgeon and the surgical field.

Means retains antimicrobial activity in the presence of pus, blood, etc., But there is a decrease of its efficiency.

Pharmacodynamics and pharmacokinetics

When applied topically Shlorhexidine agent is not absorbed into the bloodstream and the system is not affected.

Indications

Why use an antiseptic, can be found in the detailed annotations to the drug. It is widely used for the treatment of diseases that provoke microorganisms sensitive to the effects of chlorhexidine and its prevention.

The drug used for the treatment of certain diseases, depending on the concentration of the solution.

A solution of 0 05% 0 0 1% and 2% is widely used for the prevention of infectious disease after surgical interventions performed. The practice of applying such solutions in dentistry, to process dentures. As used in dentistry Chlorhexidine dentists determined in the course of various manipulation and use it to stomatitis . periodontitis   rinse the gums.

Practiced in urology skin treatment (if necessary penetration into the urethra, etc.), Surgery, gynecology surgery before and after it in order to prevent infection. Application in gynecology practice facility for the purpose of disinfecting the skin and mucous membranes prior to the series of manipulations. As the solution used depends on the type of procedure or manipulation.

In Gynecology also used chlorhexidine for thrush. To get rid of yeast infection, douching woman show under the special scheme.

Chlorhexidine is used in the treatment of many dermatological diseases, with both bacterial and fungal origin. It also shows the use of funds in the presence of purulent wounds, mucosal disease provoked by microorganisms sensitive to the active ingredient of the drug.

What is Chlorhexidine is known to those who are seriously injured. Means commonly used for treating wounds and lesions of the skin to prevent infection. What is it, and whether to use the tool in a particular case, determined by the physician.

Chlorhexidine digluconate is used for the prevention of diseases that are transmitted through sexual contact - Genital herpes . Chlamydia . trichomoniasis . Syphilis . gonorrhea .

Chlorhexidine digluconate 0, 5%   used for the treatment of skin and mucosal lesions, as well as for the treatment of medical instruments (solution temperature should be 70 degrees Celsius).

Chlorhexidine digluconate 1%   used for prevention of infection sites burns, wounds, for disinfecting operations and also for processing tools and instruments which can not be subjected to heat treatment.

Chlorhexidine digluconate 5% and 20%   used in the preparation of solutions based on water, alcohol or glycerin.

Contraindications

Notes the following contraindications to the use of this tool:

• High sensitivity to component funds.
• Not applicable for the treatment of patients suffering from dermatitis .
• Not applicable at the same time with other antiseptics (this hydrogen peroxide and etc.).
• It is not advisable to use for the disinfection of the operative field before surgery or after surgery on the CNS and the ear canal.
• Not applicable in ophthalmology (answer to the question whether it is possible to wash out the eyes of these funds - negative, as in ophthalmology used only specially prepared solution).
• For the treatment of children is used with caution.

Side effects

When used in the treatment of chlorhexidine digluconate some patients had the following side effects:

• dry skin;
• itchy skin ;
• rash;
• Dermatitis ;
• photosensitivity.

Prolonged use of funds for irrigation and rinsing the mouth may vary taste, appears odontolith , There is discoloration of the teeth.

Instructions for use chlorhexidine digluconate (method and dosage)

Instructions on Chlorhexidine provides that water and alcohol solution of chlorhexidine used for the topical treatment of infectious diseases.

Instructions for use chlorhexidine digluconate for the prevention of sexually transmitted diseases following. 0 05% solution is used no more than two hours after unprotected sexual intercourse. Men are 2-3 ml injected funds in the urinary tract, women entered into the urinary canal 1-2 ml and 5-10 ml into the vagina (as douching in gynecology). It is also desirable to treat a solution of the skin near the genital organs. Instructions how to use the drug in this case, contains a warning that urination should be done no sooner than 2 hours after using the drug. Otherwise effectiveness decreases.

For prevention in this case it can also be used with candles Chlorhexidine digluconate.

How do douching chlorhexidine thrush   and other gynecological diseases, and whether douche when certain symptoms, be sure to ask the pre-gynecologist. For irrigation use ready solution 0, 05%, which is further diluted required. Before douche, you need to lie horizontally and squeeze a few drops of the bottle into the vagina, lie down for a few minutes. With the development of allergic reactions to carry out such procedures should not be.

Dosing Chlorhexidine inflammatory diseases of the urinary tract following: a urinary canal administered 2-3 ml 0, 05% once or twice a day. The course of treatment lasts 10 days. This method of use is practiced in both men and women.

For the purpose of treatment of burns, wounds and other skin injuries drug solution is applied 0 05% 0 02% or 0 to 5%. It is used, producing irrigation or application. Administration is left for a period of from 1 to 3 minutes. Spray can also be used with the same active ingredient.

If you want to disinfect the skin before surgery used 20% chlorhexidine bigluconate that diluted to 70% ethanol (1 part 20% chlorhexidine bigluconate and 40 parts of 70% alcohol). Operating field treated twice at an interval of 2 minutes.

In ENT practice, a chlorhexidine sore throat . pharyngitis . tonsillitis . It should gargle with angina solution of 0, 2%, or 0 5%.

Before use of chlorhexidine gargling Recommended to carefully rinse the mouth with warm water. Next gargling in angina carried out as follows: we should take 10-15 ml (about a tablespoon) solution, which can gargle for about 30 seconds. You can repeat these steps once. After rinsing, it is desirable for 1 hour do not eat or drink. As a gargle with chlorhexidine, and how many times a day to carry out this procedure for the throat, tell the doctor based on the individual patient's symptoms. Also, a specialist should be asked whether you can gargle with chlorhexidine, if the patient says the side effects.

Note that if the chlorhexidine mouthwash causes a burning sensation, then most likely, the solution has too high a concentration. Maximum permissible concentration - not more than 0, 5%. Pre instructions should be studied as a mouthwash diluted drug. Rinsing the mouth after a tooth extraction is carried out three times a day for 1 minute. Can you rinse your mouth and how often to rinse your mouth if observed complications after tooth extraction, it is necessary to learn from the expert.

Chlorhexidine during the rinse can not swallow Accidental solution into the stomach to drink activated charcoal tablets (1 tablet per 10 kg body weight).

Rinsing the nose with the sinusitis   this drug should not be practiced independently. Can I clean the nose, which is determined by the doctor. The solution scored in the nose can get into the cavity of the inner ear or in the lining of the brain, which is fraught with the development of serious complications.

Overdose

According to the instruction, an overdose of the drug possible. If swallowed, the drug shown holding gastric lavage , The use of Activated Carbon , Symptomatic treatment.

Cooperation

If the pH exceeds 8, precipitate. If the preparation of the solution was used hard water, its bactericidal effect decreases.

Not compatible with anionic compounds, in particular with soap.

Do not mix with chlorides . carbonates . phosphates . sulfates, borates . citrates .

Under the impact of the increased sensitivity to the effects of micro-organisms neomycin . kanamycin . chloramphenicol . cephalosporin .

Ethyl alcohol enhances bactericidal effect.

Terms of sale

Sold in pharmacies without a prescription.

Storage conditions

The drug should be stored in dark, dry place, storage temperature - from 1 to 25 degrees Celsius.

Shelf life

A solution of 0 05%   It can be stored for 2 years.

A solution of 20%   It can be stored for 3 years.

Prepared solutions can be stored for one week.

Cautions

The solution remains active in the presence of blood impurities and organic substances. The drug should be avoided contact with eyes, lining of the brain and to the auditory nerve.

People with an open head injury , Spinal cord injury, perforation of the eardrum   you need to avoid getting funds for the surface of the brain, the meninges and in the tympanic cavity.

After contact with the eyes, immediately rinse them.

Do not mix with other detergents and disinfectants.

If the vehicle has been in contact with clothing should not affect it hypochlorites That produce active chlorine.

Analogs

Analogs of chlorhexidine digluconate - are drugs that contain similar active substance. Analogs produced in a variety of dosage forms - gels, solutions, ointments, suppositories. It Hexicon . Hexicon D   (children) Gibiskrab . Amident   and etc.

It may also be used other antiseptic agents - such as iodine or hydrogen peroxide.

Is it better or chlorhexidine   Miramistin ?

Many people are convinced that Miramistin and Chlorhexidine - is the same. In fact, these drugs actually belong to the same class of antiseptics. What is the difference Chlorhexidine and Miramistin - is in active substances contained in the preparations. Miramistin - this is not a complete analog Chlorhexidine. He has a strong anti-fungal and antiviral effects. Therefore, there are some differences in the indications for use of the drug. Miramistin not contraindicated for people suffering from dermatitis.

Synonyms

Hexicon.

Babies

For the treatment of children the drug is used with caution and only after a doctor's appointment.

During pregnancy and lactation

Chlorhexidine in pregnancy and during breast-feeding can be applied topically. However, despite the fact that the pregnancy is not a contraindication to the use of the drug, prolonged use is not recommended solution.

Gargling during pregnancy is possible only under medical supervision.

Reviews of chlorhexidine

Reviews on chlorhexidine digluconate mostly positive. Experts and patients notice a pronounced antiseptic effect when using the solution. Positive results using the solution marked with gargling, in dentistry, in gynecology. Side effects in patients are very rare. The positive effect observed when using acne reviews in this case as well.

Chlorhexidine is used for the entity in the form of a solution of 0.01%, it has an antimicrobial effect upon penetration into the skin. However, the review notes that the fact whether it is possible to wipe the face of such a solution, it is best to ask a dermatologist as there may be an individual response to the drug.

If you believe the reviews, Chlorhexidine acne cures effective if used correctly. The means need to wipe the area around the structures on the face. Many say that fast, you can get rid of acne by applying it in combination with other agents.

Shampoo with 4% chlorhexidine has been used successfully for the prevention of skin infections in pets. According to reviews, this shampoo for dogs and cats cleans the skin and makes the hair silky.

Price Chlorhexidine where to buy

Price depends on the concentration of chlorhexidine solution. Most often, you can buy in pharmacies Chlorhexidine 0, 05% Which is ready for use. The cost of this drug in Moscow is about 12-18 rubles per 100 ml. If the place of realization - Ukraine, the price of the solution is about 5-6 USD. per 100 ml.

Cost candles Chlorhexidine   It is 210-240 rubles. 10 pcs. Cost Chlorhexidine digluconate Spray   - 14-20 rubles. How much does a pharmacy gel containing chlorhexidine is dependent on the drug. The price is approximately 100 rubles.