Description overdue on 04/30/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Retin A (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Cream Retin A consists of 0, 05% strength, and cream tretinoin .

Product form

Ejection means in the aluminum tube 30 g tube is in a carton.

Pharmacological action

The drug has keratolytic, protivoseboreynoe, antitumor, komedonoliticheskoe and local anti-inflammatory effect.

Pharmacodynamics and pharmacokinetics

Retin A is a retinoid , Structurally similar to the Vitamin A . When applying inwardly inhibits the growth and differentiation of modified blood cells, including cells mieloleykoznye. External application allows to strengthen in the papillary dermal layer polifertatsiyu cells, reduce the adhesion of the cells that are involved in the formation of acne.

Treatment of open blackheads   It leads to align skin without inflammation. Closed acne   the processing of drug Retin A are open or papules That after removal of keratin plug heal without scarring. As the cream reduces the risk of the formation of new acne.

Tretinoin , Which is a natural metabolite of retinol, absorbed from the gastrointestinal tract. Its concentration in the plasma after 7-12 hours endogenous returns to its original level. High levels of binding to plasma proteins does not cumulate. The urine tretinoin displayed about 60%, the rest - the faeces.

Indications

External application of:

• eels vulgar   (to form a papules . comedones   or pustules );
• Favre disease-Rakusha ;
• drain acne .

Ingestion is indicated for acute promyelocytic leukemia .

Contraindications

Apply the product inside is contraindicated in Lactation . pregnancy Sensitivity to tretinoin, cutaneous epithelioma   history.

Outdoor use is prohibited in the presence of wounds, acute inflammatory skin lesions . burns .

Side effects

Receiving drugs can cause the following effects:

• fever . pulmonary infiltrates . dyspnea . hypotension , Respiratory distress syndrome . pleural effusion . hepatic failure . breathlessness . hyperskeocytosis . renal failure ;
• cellulitis , Rash, dry mucous, sweating, cheilitis . dermatoxerasia . erythema . alopecia . xerophthalmia . exfoliative dermatitis Itching;
• nausea, stomatitis . diarrhea , Vomiting, dry mouth, abdominal pain, constipation , Increased activity of liver transaminases;
• depression , Impairment of consciousness, disturbance of vision, hearing, increased intracranial pressure, anxiety, dizziness;
• weight change, increased cholesterol, plasma triglycerides;
• stridor, pharyngitis , Pleural effusion, shortness of breath, swelling of the mucous membrane of the nose, wheezing in the lungs;
• Arrhythmia ;
• pain in the bones, joints and muscles;
• increased bleeding;
• chills Weakness, fever , Drowsiness, back pain, chest.

When applied topically may appear redness, peeling skin, swelling, burning, photosensitization The appearance of crusts, blisters.

Instructions on Retin A (method and dosage)

The medicine is suitable for both indoor and outdoor applications.

Dosage is assigned to each individual patient depending on factors such as the indication, disease stage, tumor therapy scheme.

Overdose

Data on drug overdose is not available.

Cooperation

Pharmacokinetic parameters can be changed while the application of tretinoin with drugs affecting enzymes of CYP450.

The contraceptive effect progesterone   It reduced due to the use of tretinoin.

The combined use of tetracyclines   It can lead to increased pressure inside the skull.

Supervitaminosis   It can be observed in the consumption of vitamin A.

Terms of sale

Over the counter.

Storage conditions

Cream should be hurt in a cool dry place at 15-25 ° C.

Shelf life

3 years.

Cautions

An appointment inside Retin A can only physician who has experience in treating cancer and hematological diseases.

Chemotherapy in adequate dose appointed with a strong increase of leukocytes to prevent retinoic acid syndrome . Dexamethasone   appointed in the event of the first symptoms of this syndrome.

Do not allow to enter the cream in the mouth, eyes, mucous membranes; in contact - rinse thoroughly with water.

During the first week of the course may increase acne.

Avoid sun exposure during treatment. The course can be started after the lowering sun.

Do not use tretinoin those agents that cause desquamation of the skin . So it is not necessary during treatment to use hygienic and cosmetic products, which cause irritation and dryness of the skin.

Analogs

By the analogues of the given preparation can be attributed lokatsid . vesanoid   and tretinoin .

During pregnancy and lactation

If it is necessary take the drug inward, should be temporarily to cease BREAST-FEEDING.

Retin A is contraindicated in pregnant women.

One month before the start of the course, during the course and one month after cessation of women should use effective contraception. Apply start at day 2 or 3 of the menstrual cycle. It recommended laboratory tests to confirm the absence of pregnancy before beginning therapy at least 2 weeks. During treatment, every month should be carried out tests.

Reviews for Retin A

Patients who leave comments on Retin A, there was a strong increase in acne at the beginning of treatment, as well as flaking of the skin. Many people are advised not to use at this time of any creams, as this will further worsen the situation.

Price Retin A, where to buy

Price cream in Ukraine is about 220 USD. In Russia, Retin A is Oklo 1044 rubles.

Buy Retin A in Moscow and its price may be clarified in the pharmacy.