Description overdue on 12/16/2014

• Composition
• Product form
• Pharmacological action
• Pharmacokinetics and pharmacodynamics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

As part of the preparation contains rabies immunoglobulin As well as additional components glycine glycine as stabilizer, water and sodium chloride. Antibiotics   means a composition does not contain. It also no antibodies to HIV, HCV, HBsAg.

Product form

Rabies immunoglobulin is produced as a solution for injection. It can be transparent or slightly opalescent. The liquid colorless or pale yellow. The drug is packaged in bottles of 1, 2, 5 ml.

Pharmacological action

Rabies immunoglobulin   - A concentrated solution of purified gamma globulin fraction of the serum. It stands out from the blood by the method of cold ethanol extraction. Further, the substance is in the process of ultrafiltration, it was purified and inactivated to ensure removal of viruses. The drugs have specific antibodies that can neutralize the virus Rabies .

Pharmacokinetics and pharmacodynamics

The highest level of antibodies in the blood observed after 2-3 days after the drug was administered to a patient intramuscularly. Antibody half-life is three to four weeks.

Indications

Rabies immunoglobulin is administered in combination with rabies vaccine for the prevention of hydrophobia   in people who have received multiple or severe bites rabid animals or sick animals that are suspicious for rabies.

Repeated multiple bites rabid or suspect animals for the presence of rabies medication is not administered if the patient after the first bite took a full course of the combined therapy of rabies. In this case, you only need to assign a rabies vaccine.

Contraindications

Given the fact that this tool is assigned to the presence of vital signs. Not determined contraindications to its use. People who have celebrated high sensitivity   to human blood products, as well as pregnant women should be administered only in a hospital immunoglobulin.

Side effects

Some people in the early days after the receipt of funds (in the first few days) can develop hyperemia It appears puffiness . Perhaps the increase in body temperature to subfebrile figures.

Very rarely can develop allergic reactions expressed: angioedema , Manifestations hives . anaphylactic shock . Therefore, after introduction of a preparation a person must necessarily to remain under supervision of a specialist not less than thirty minutes.

Instructions for use (method and dosage)

If a person suffered from the bite of of the animal, should promptly treat the surface wounds. It is recommended to wash the wounds and to treat them with alcohol or Iodine solution   alcohol. If necessary, the wound is treated surgically.

Further, specific therapy should be used. Bottle accommodating rabies immunoglobulin, before the introduction should be carefully checked for integrity and determine whether the necessary markings on it, you saved all the physical properties of the solution.

Instructions on rabies immune globulin provides that the agent is administered in strict compliance with all the rules of aseptic and antiseptic. It is not necessary to carry out a skin test prior to administration of the drug. It is desirable to introduce the medication as soon as possible after receipt of the wound, wherein the dose is 20 IU per 1 kg of body weight of an adult or child. The exact calculation of the dose conducts physician immediately prior to administration.

Most of the dose should infiltrate around the wound and deep wounds. The rest of the funds administered intramuscularly.

Adults who receive an injection in the buttock, is administered to children in the anterolateral thigh.

If necessary administration to children, especially those who have observed multiple injuries, rabies immunoglobulin can be diluted with 0.9% sodium chloride solution to the level that will allow for complete infiltration of wounds. Deposit of funds is necessary not later than 7 days after the person in contact with animals suffering from rabies or suspected of having the disease.

Combination therapy should be carried out so as to strictly adhere to a number of conditions. Initially, the patient should be administered rabies immunoglobulin, then, after 30 minutes, you must enter the rabies vaccine. Such a sequence of administration of these drugs should be strictly observed. Not allowed immunoglobulin after rabies vaccine.

The above two agents must be administered in different areas of the body while using different syringes.

In no case can not exceed the dose of immunoglobulin, since overdose may result in partial suppression of antibody production.

If the patient is necessary to provide emergency prevention Tetanus , It can be carried out only after the entered rabies immunoglobulin and the first dose of the vaccine carried rabies.

Overdose

Overdose means no data.

Cooperation

You can carry out the injection of rabies immunoglobulin in the same time as the emergency prevention of tetanus. Other drugs may be administered only after a lapse of three months after the end of a combination of anti-rabies treatment.

Terms of sale

The drug is intended for treatment and prevention institutions.

Storage conditions

It is necessary to save and to transport a means of, adhering to of temperature from 2 ° up to 8 ° C, should be to cherish a medicine from ingress of of light ,, to freeze it is impossible. Keep away from children.

Shelf life

Shelf life - 2 years.

Cautions

You can not enter rabies immunoglobulin intravenously.

Use the solution immediately after opening the vial. The remaining solution can not be used later.

Do not administer the drug after administration began a course rabies vaccine .

If the patient says hypersensitivity   to heterologous immunoglobulins and serum during the drug administration should be assigned antihistamine drugs for 1 to 10 days. It is important to maintain careful observation of man. Intravenous administration is contraindicated, however important to ensure that the injection process, the needle does not hit the blood vessel.

Before treatment is necessary to inform your doctor about taking any other medications.

Babies

Babies agent appointed by prescription, administered at a dosage indicated in the instructions in the anterolateral thigh.

During pregnancy and lactation

With pregnancy   practiced by administering the drug in the presence of vital evidence.

Reviews

Reviews of this preparation rarely leave. It is noted that its application in the complex treatment allows to prevent the development of dangerous disease that causes the rabies virus.

Price, where to buy

The cost of 1 bottle of rabies immunoglobulin is from 1300 rubles.