Description overdue on 20.01.2012

The antiviral drug . Ribavirin intentionally penetrates the cells affected by the virus. Inside the cells under the action adenosine   Ribavirin is phosphorylated to phosphate metabolites. Effect of the drug is aimed at reducing the number of guanosine triphosphate , Suppression of protein synthesis and RNA. The drug inhibits the replication of new virions , Thereby reducing the viral load. By the action of the drug most sensitive: paramyxoviruses, oncoviruses, reoviruses, pox virus group, a herpes simplex virus. Ribavirin is available in tablet form, capsules, concentrate for solution.

Indications:

Ribavirin administered in combination with interferon alfa for chronic hepatitis C. The drug is effective in HFRS (injection).

Contraindications:

Ribvirin not used for renal failure of the system, myocardial infarction, pregnancy, severe anemia, breastfeeding, cirrhosis   decompensated, in autoimmune diseases. In COPD, diabetes   decompensated, thyrotoxicosis , Thyroid disease, pulmonary embolism , Hemoglobinopathies, thrombophlebitis , Coagulation disorder, sickle-cell anemia, Thalassemia , Suicidal tendencies and depression during the drug is prescribed with caution.

Side effect:

Nervous system Depression, fatigue, insomnia, headaches, dizziness. Cardiovascular system : Heart failure, bradycardia, decreased blood pressure.   Forming Organs : thrombocytopenia , Granulocytopenia, neutropenia, leukopenia, hemolytic anemia. Respiratory system:   cough dyspnea . Digestive system : Hyperbilirubinemia, nausea, loss of appetite. Allergic reactions, angioedema , Anaphylaxis, hair loss, skin rash, bronchospasm . When the inhalation of medical workers may cause swelling of the eyelids, redness of eyes, and headaches.

Mode of application:

Tablets and capsules are taken by mouth, preferably with meals, not chewing and drinking water. When viral hepatitis C. Ribavirin is taken twice daily, a daily dose of 1-1, 2 grams. If the patient's weight more than 75 kg of 0, 6 grams of morning and evening. Weighing less than 75 kg: 0, 4 grams of the morning, 0, 6 grams evening. The course of antiviral therapy lasts 24-48 weeks. At relapse in patients refractory to monotherapy treatment lasts from six months.

Special instructions:

Ribavirin is teratogenic for medical personnel working with the drug. Persons of reproductive age during therapy and for six months after recommended the most effective means of contraception. During treatment at the 8th week marks the maximum fall in the level of hemoglobin in the blood. When less than 11 g Hb / dL the dosage of ribavirin is reduced by 400 to 400 mg per day. With average Hb below 8, 5 g / dl treatment ceased. During therapy allowed transient skin rash, fatigue. It is recommended to give up control of complex machinery, vehicles.

Drug Interactions:

Formulations in the composition containing ions of Al 3+, Mg 2+, and simethicone   adversely affect the bioavailability of ribavirin. Synergistic effect observed when combined with interferon alfa Antagonism - a zidovudine .