Description overdue on 17.10.2011

The main active substance - azithromycin . Antibacterial drug. Azithromycin has a broad spectrum of activity, a representative azalides   - The new macrolide. Sumamed in high concentrations in inflammatory foci has a strong bactericidal effect. The drug is quickly and fully into the respiratory tract, urogenital organs and tissues (prostate), soft tissue, skin. Due to the low binding of the base material azithromycin blood protein, the ability to concentrate in areas with low pH, the possibility to enter the body of a typical cellular organization (eukaryotic cells) provides long half-life and high drug concentration in the tissues. For the elimination of pathogens with intracellular structure of azithromycin has the ability to accumulate in lysosomes . The antibacterial agent is delivered in the inflammation phagocytes And is released as a result of phagocytosis . The infectious foci Sumamed drug concentration is significantly higher than in healthy tissues and organs. PM has no effect on the function of phagocytes. After ingestion bactericidal concentration of azithromycin in inflammatory foci stored for 7 days after the final dose, which allows for brief courses of treatment (days 3 and 5).

Dosage Form:

Pills. Capsules. Syrup.

Indications:

Sumamed prescribed for infections of upper respiratory tract and respiratory tract, pneumonia   ( SARS ) bronchitis , Infection of the skin and tissues: impetigo . Medicine . mug . Infections of the urogenital system: urethritis   (negonoreyny, gonorrheal) cervicitis . Lyme disease .

Contraindications:

Allergy to macrolides. Pronounced irregularities in the kidneys and liver. Be wary appoint patients who are prone to allergic reactions.

Side effect:

Dyspepsia, flatulence . Transient (transient) increase in liver enzymes. Rarely - skin rash.

Mode of application:

Sumamed children weighing more than 10 kg are given of calculation: 10mg / kg on the first day of treatment, followed by 5 mg / kg for 3 days (rate - 30 mg / kg). Adults with respiratory tract infections: take medication 1p. daily for 3 days at 500 mg. Erythema migrans (chronic form) on the first day of 1 g, the second through the fifth 500 mg. STD: a single dose of 1 g Sumamed taken for 1h before eating or 2 hours after after 1 time per day.

Overdose:

Diarrhea, transient hearing loss, nausea. Treatment includes gastric lavage, followed by a reception adsorbents.

Special instructions:

Patients with severe disorders of the liver, kidneys prescribed with extreme caution. In the absence of reliable information on the impact of Azithromycin   fetal drug is not prescribed to pregnant women (in exceptional cases - where the benefits greatly exceed the potential risk of negative impact).

Drug Interactions:

Sumamed enhances efficiency dihydroergotamine . ergot alkaloids . Chloramphenicol   and tetracyclines   enhance the effect of the drug, and linkozaminy On the contrary, reduced. Eating, ethanol, antacids   It reduces and slows down the absorption of the active substance. Azithromycin reduces the rate of excretion, toxicity increases cycloserine . methylprednisolone , Anticoagulants, felodipine . carbamazepine . hexobarbital . valproic acid . phenytoin . bromocriptine . dizopiramida . theophylline , Oral hypoglycemic drugs. The drug is not compatible with Heparin .