Description overdue on 01.11.2011

The preparation Valtrex   It is a specific inhibitor DNA polymerase   Virus Herpes . After its application the process of blocking viral DNA synthesis and replication of viruses. The drug is getting into the human organism, transformed into acyclovir   and L-valine . In its turn, phosphorylation of acyclovir is converted into active acyclovir triphosphate . It is able to effectively inhibit the viral DNA polymerase. In the first stage phosphorylation takes place under the influence of virus enzyme. The drug is active against the viruses Herpes simplex   first and second types of virus Varicella zoster On virus Epstein-Barr . CMV As well as herpes virus sixth type.

Indications and methods of use of the drug:

Valtrex acts effectively in the treatment of shingles , A number of diseases of the mucous membranes and skin, which stimulates the development of the virus Herpes simplex (among others - and genital herpes ). Valtrex is also effective in the prevention of recurrence of the disease, which causes the virus Herpes simplex.

The drug is administered orally. In the course of treatment of herpes zoster should take Valtrex 1 g three times a day for a week. Patients with Herpes simplex virus preparation is administered at 500 mg twice a day. For the treatment of relapse of diseases that provokes the virus Herpes simplex, you need to start therapy in the prodromal period or immediately after the first symptoms appeared. Treatment should be continued for five days, but in the first stage of its length can be increased up to ten days. With CRF   the dose should be reduced: in patients with herpes zoster appoint 1 g of the drug every twelve hours with CC 30-49 ml / min; once a day with CC 10-29 ml / min; 500 mg once a day with less CC 10 ml / min. Patients with a simple (including genital) herpes should take 500 mg every twelve hours with CC 30-49 ml / minute or once per day at CC than 30 ml / min. If the patient hemodialysis, the drug should be administered after the procedure.

Contraindications and possible side effects:

You can not use the drug in the presence of hypersensitivity to its components. The drug is not prescribed to patients who underwent transplantation bone marrow   or kidneys , Patients with symptomatic forms HIV infection . Very carefully prescribed Valtrex to patients with hepatic or renal insufficiency, pregnant and lactating women and children.

Upon receipt of the drug may be a manifestation of a number of side effects. There may be nausea, vomiting, poor appetite, stomachalgia , Dizziness, headache, fatigue level is too high. It may also occur renal failure, hemolytic anemia . microangiopathy . thrombocytopenia   (the latter being immunocompromised patients who received higher doses valacyclovir   naprotjazhenii long period). Sometimes it is also seen increased activity of AST. In case of overdose, the residue of the drug will be deposited in the renal tubules. To treat this condition has been used successfully dialysis .

Specific recommendations:

Usually viruses with reduced sensitivity diagnosed in patients who suffer severe immunocompromised . Low sensitivity of viruses to the drug caused phenotypic deficiency thymidine kinase   in cells that have been infected with a virus. Elderly people during treatment should consume more fluids. To date, there is little experience of the drug Valtrex in children. During therapy of genital herpes should not be allowed sexual contact, because the drug can not protect against infection. In the case of taking the drug at high doses and for a long period in patients undergoing bone marrow transplantation who have symptomatic forms of HIV infection, and consequently with immunodeficiency, can develop thrombocytopenic purpura   and gemolitikouremichesky syndrome . This can lead to death.