Description overdue on 12.05.2012

The antiviral drug . The main ingredient is acyclovir. The active ingredient of the drug presented Viroleks thymidine nucleoside analogue synthetic origin. The principle of exposure to viral cell based on the transformation and the impact of the active substance on the enzyme thymidine kinase virus. Acyclovir highly specific, vysokoselektiven. The drug accumulates in cells infected is a virus herpes. The drug is highly active against the pathogen shingles , Varicella zoster virus, Epstein-Barr virus, herpes simplex against the first and second type. Acyclovir has a moderate effect on tsitmegalovirus. The active drug substance has immunostimulatory effect . Viroleks produced in the form of capsules, ointments, tablets, lyophilizate, suspension, lotions.

Indications:

Viroleks prescribed for severe and recurrent course Genital herpes , For prophylaxis herpes. The drug is used for herpes zoster, chickenpox.

Contraindications:

Viroleks not prescribe intolerance acyclovir, valacyclovir. Breastfeeding and carrying a pregnancy acyclovir used with caution. Intravenous infusion is carried out after consultation of experts in dehydration, renal pathology system while receiving cytostatics.

Side effect:

Viroleks can cause allergic skin reactions, anaphylactic reactions , Stevens-Johnson syndrome, fever, increased liver enzymes, blurred vision, peripheral edema, leucopenia, hallucinations, lymphadenopathy, leucopenia, headache, exudative erythema . At parenteral introduction probably development of phlebitis, signs of encephalopathy, insufficiency hepatic the system, hemolytic violations, of hemolysis, of mental disorders, of hematuria, drop in blood pressure, psychosis, oppression mental state, DIC . If ingestion Viroleks cause alopecia, disturbances in the digestive tract, malaise, myalgia, dizziness, agitation , Somnolence, paresthesia, abdominal pain, nausea.

Overdose:

Reception 20 grams of acyclovir does not cause the development of certain specific symptoms. When bolus, parenteral administration of high doses observed violations of water-electrolyte balance, hypercreatininemia, coma, convulsions , Increase of urea nitrogen, lethargy, violations of in the work of the renal system. Requiring hemodialysis, the maintenance functions of the affected organs.

Mode of application:

Viroleks administered intravenously, orally, topically. Immunocompromised patients for the prevention of recurrence of herpes simplex acyclovir administered every six hours on 200mg. In marked immunosuppression, increase the dose to 400 mg five times a day. Duration of antiviral therapy for 5 days. Initial therapy for genital herpes: 20 mg 6 times during wakefulness. Treatment herpes simplex: 5 time in the day by 200-400mg, the course 10 days. When herpes zoster Viroleks is prescribed in a an amount of 800 mg of every four hours during wakefulness. When herpes simplex lesion generalized newborns Viroleks administered for 10 days every 8 hours with 10 mg / kg.

Special instructions:

In patients with reduced immunity long-term therapy with acyclovir can cause the emergence of viruses, which are resistant to the active agent for of the drug Viroleks. Authentic data on complete safety the use of of a medicament in pregnant women not. Treatment with acyclovir during pregnancy is justified only in situations where the benefits of treatment outweigh the possible effects of the drug to the fetus. When oral therapy is recommended to ensure the patient plenty of fluids. During treatment she will need to stop breast-feeding. Viroleks does not protect from the transfer of herpes at sexual contact, so patients is necessary to refrain from of sexual contacts at the moment of therapy.

Drug Interactions:

When concomitant administration of immunostimuljatorov   recorded increase in effect. In the case of mixing the solutions with drugs, it is important to consider when administered intravenously alkaline Viroleks preparation. In the appointment of tubular secretion blockers showed a decrease secretion in the tubules to acyclovir administered, leading to an increase in drug concentration in the cerebrospinal fluid, blood. Also registered increase in toxic effects, lengthening the half-life of the organism. Appointment nephrotoxic agents   It increases the likelihood of the defeat of the renal system.