Description overdue on 09-01-2012

Vasodilators . Mainly active substance acts pentoxifylline It refers to a group of purines. Agapurin improves the rheological properties of blood, microcirculation . The mechanism of action is based on the increase of cAMP in platelets, inhibiting phosphodiesterase , Raising the level of ATP in erythrocytes. The drug reduces the round, causing vasodilation, it does not affect the heart rate. When the expansion of the coronary arteries increases the delivery of oxygen to tissues infarction Improves blood oxygenation . Pentoxifylline tones the muscles of the diaphragm, the intercostal muscles, respiratory muscles. When intravenous injection is enhanced collateral circulation, increases the volume of blood flowing through a unit cross section. Agapurin positive effect on the bioelectric activity of the nervous system, increases ATP levels in brain tissue. Pentoxifylline increases the elasticity of red blood cells, causing the disaggregation of platelets, reduces blood viscosity. The drug affects the diseased blood cells deformability of red blood cells. In areas with impaired circulation improves. With intermittent claudication   (Peripheral arterial occlusive disease), the drug increases the distance away, it eliminates pain at rest and night cramps in the calf muscles. Agapurin produced in the form of capsules, dragees, concentrate solutions, tablets.

Indications:

Agapurin prescribed for Raynaud's disease , Peripheral circulatory disorders, post-thrombotic syndrome , Frostbite, gangrene, trophic ulcers of the lower leg, occlusive disease . The drug is effective in stroke, cerebral arteriosclerosis, viral neuroinfection , Vascular encephalopathy. Pentoxifylline is used in cardiac ischemia, myocardial infarction, with otosclerosis . Impotence   vascular origin, asthma , COPD.

Contraindications:

Agapurin not prescribed for   porphyria , Acute myocardial infarction, hypersensitive to pentoxifylline, xanthine derivatives. The drug is contraindicated in breast-feeding, hemorrhagic stroke , Massive bleeding, pregnancy, bleeding in the retina of the eye. Intravenous administration of the drug is not permitted in the uncontrolled hypotension, cerebral atherosclerosis, coronary artery disease, arrhythmia. When blood pressure instability, tendency to low blood pressure, ulcerative lesions of the gastrointestinal tract, liver failure and renal systems after surgery. Not available in pediatrics before reaching adulthood.

Side effect:

Nervous system : Anxiety, headaches, dizziness, seizures, sleep disorders. Skin : Edema, brittle nails, facial flushing. Digestive system : Intestinal, loss of appetite, cholestatic hepatitis , Exacerbation of chronic cholecystitis , Dryness in a mouth. Senses : scotoma , Disorders of visual perception. Cardiovascular system : Drop in blood pressure, progression angina . cardialgia , Arrhythmia, tachycardia. Organs of hematopoiesis : pancytopenia , Bleeding, gipofibrinogenemia. Perhaps the increase in liver enzymes, allergic.

Overdose:

Higher doses of the drug Agapurin leads to increased severity of side effects, tachycardia, drop in blood pressure, dizziness, convulsions . arefleksiya , Hyperthermia, loss of consciousness. Recommended emergency gastric lavage, adsorbents, support of vital functions of the body.

Mode of application:

Intra-arterial and intravenous administration of a drug with the patient lying down. Prior to intravenous administration of 50 mg of the preparation is diluted in 10 ml of sodium chloride are introduced slowly, dropwise. Intramuscular injections are carried deep 2-3 times a day for 100-200 mg. Tablets do not chew, wash down with sufficient amount of liquid. The daily dosage recommended split into three stages. The initial dose, 600 mg per day.

Special instructions:

Treatment is carried out under the control of blood pressure. Patients with diabetes   when using the drug Agapurin endocrinologist should be consulted for the correction of hypoglycemic therapy. Simultaneous reception anticoagulants   It requires monitoring of blood parameters. The elderly is recommended to reduce the dosage in half. The therapeutic effect of the drug is reduced during smoking. Before intravenous administration is recommended to check the mixture agapurin and infusion solution compatibility.

Drug Interactions:

Agapurin enhances the action of drugs that affect blood clotting ( thrombolytics , Anticoagulants direct and indirect). Pentoxifylline improves valproic acid Antibiotics: tsefotetan, tsefaperazon, tsefamandola. Action insulin , Antihypertensives enhanced by simultaneous application of pentoxifylline. The concentration of drug in the blood when applied cimetidine . Simultaneous treatment with xanthine causes excessive excitement.