February 22, 2012

A key mechanism that creates resistance TB   to antigens , Has been identified by US researchers, told Medical Xpress.

Today, tuberculosis is very difficult to treatment . Even the most simple cases involve the treatment of this disease with simultaneous use of a set of antibiotics . At the same time, the treatment lasts for at least six months. The most dangerous is the fact that an increasing number of strains   pathogen eventually become resistant to the applicable preparations .

The main cause of this resistance   - Specific structure of the cell walls of bacteria. It consists of mycolic acid Which provide good protection against external influences. In the absence of these acids mycobacterium die. Today, scientists have known that these acids are produced within the cell - the exciter, after which they are located on the cell wall through the membrane. But for a long time could not find a transmembrane molecule carrier, despite the best efforts of scientists.

For 30 years, experts from the Colorado State University have tested a wide variety of substances, determining their antimicrobial activity coupled with the exciter tuberkuluza. And recent studies have been completed successfully - was found a substance that is very effective in stopping the growth of bacteria   in a nutrient medium.

A detailed study of this matter and the mechanism showed that blocking occurs mycolic acid transporter, which has also been identified. The discovery of the protein provides a new direction of creation of highly effective drugs, as its blockade leads to the destruction of the bacteria.

A detailed description of acid transporter that is not disclosed due to the fact that this molecule was opened recently and is now in need of a detailed study. It is also not called and the substance, which has revealed a molecule.