Description overdue on 06/02/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications corinfar
• Contraindications
• Side effects
• Instructions for use corinfar
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One tablet Corinfar   It comprises:

• nifedipine   - 10 mg;
• Excipients: lactose monohydrate   - 15.8 mg, potato starch   - 15.7 mg, microcrystalline cellulose   - 15.5 mg povidone K25   - 2.7 mg magnesium stearate   - 0.3 mg.

The composition of the shell: Titanium dioxide   - 0.77 mg, Macrogol 6000   - 0.48 mg,   quinoline yellow dye   - 0.27 mg, talc   - 0.38 mg, Valium   - 2.88 mg macrogol 35000   - 0.22 mg.

One tablet Corinfar Retard   It comprises:

• nifedipine   - 20 mg;
• Excipients: lactose monohydrate   - 31.6 mg, potato starch   - 31.4 mg, microcrystalline cellulose   - 31 mg, Povidone K25   - 5.4 mg, magnesium stearate   - 0.6 mg.

The composition of the shell:   Titanium dioxide   - 1.377 mg, Valium   - 5.188 mg, quinoline yellow dye   - 0.143 mg talc   - 1.038 mg, macrogol   6000 - 0.861 mg macrogol   35,000 - 0.393 mg.

One tablet Corinfar DNA   It comprises:

• nifedipine   - 40 mg;
• excipients - lactose monohydrate   - 30 mg, microcrystalline cellulose   - 48.5 mg, cellulose   - 10 mg,   hypromellose 4000 cP - 20 mg, magnesium stearate   - 1.5 mg colloidal silicon dioxide   - 0.75 mg.

The composition of the shell: Titanium dioxide - 2 mg Macrogol 6000   - 0.07 mg Valium - 2 mg iron oxide red   - 0.9 mg, macrogol 400   - 1.1 mg, talc   - 1 mg.

Product form

Corinfar   and Corinfar Retard   represent prolonged release tablets which are coated straw color, biconcave, round and with a beveled edge; the cut - homogeneous yellow solid.

10 such Tablets Corinfar   or Corinfar Retard   in blisters, three blisters in a carton box. Or 50 such Tablets Corinfar   or Corinfar Retard   in the dark glass vial, one such vial in a carton box. Corinfar also available separately the amount of 100 tablets in a bottle of dark glass and carton box.

Corinfar DNA   - Prolonged release tablets, coated dark red, biconvex, round. In 10 of these tablets in a blister; 5, 2, or 10 of the blister pack in the paper.

Pharmacological action

The drug has hypotensive   and antianginal .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

This drug is a selective blocker (inhibitor) " slow "Calcium channel refers to a chemical derivative of dihydropyridine . It stops the movement of Ca2 + from intracellular space cardiomyocytes   and crates of smooth muscle of the peripheral arteries and heart; at high doses inhibits the output of Ca2 + from intracellular stores.

For therapeutic doses normalizes intercellular Ca2 +, which can be violated in a number of pathological conditions ( hypertension   and others). It has no effect on the tone of veins. It increases coronary blood flow, increases blood flow to ischemic areas   infarction   without the syndrome "steal", stimulates the collaterals. It increases peripheral arteries, reducing the total peripheral resistance, tone infarction, the heart's need for oxygen. It does not affect the atrioventricular   and sinoatrial nodes Has slight antiarrhythmic   action. Also, the drug activates the renal blood flow.

Time of onset of clinical effect Bizkit to 20 minutes, the duration of the effect of -5-6 hours.

Pharmacokinetics

In the intestine, it absorbed 90% of the formulation. Bioavailability is about 60%. Receiving food increases the bioavailability. 95% of the drug binds to plasma proteins. The maximum concentration nifedipine   Blood ingestion of two tablets (20 mg of nifedipine) occurs 2-3 hours. Fully converted in the liver.

Excreted by the kidneys in the form of an inert metabolite (70%) in the bile (30%). The half-life is about 3-5 hours.

Renal failure, conducting Hemodialysis do not alter the pharmacokinetics of corinfar. In patients with liver disease decreases clearance and prolongs poluvyvedeniya.Pri receiving long-term (more than two months) may develop tolerance to the drug.

Indications corinfar

Indications Corinfar Retard   ( Corinfar ) And indications for use Corinfar DNA   same - the choice of the drug is carried out by the attending physician depending on the severity of the disease and individual susceptibility.

• Hypertension .
• Vasospastic angina   ( Prinzmetal angina ).
• Chronic angina.

Contraindications

• Allergy to nifedipine   and any other derivatives dihydropyridine   or components of the drug.
• Low pressure   (systolic pressure less than 90 mm Hg. Art.).
• Unstable angina .
• Cardiogenic shock .
• Hronicheskayadekompensirovannaya cardiac insufficiency Heavy aortic stenosis .
• The first four weeks myocardial infarction .
• The first 13 weeks of pregnancy.
• Period breast-feeding .
• Receiving rifampicin .

Caution should be used in the preparation Mitral valve stenosis , Heavy tachycardia or bradycardia , Malignant hypertension Syndrome sinus . hypovolemia Expressed violations Cerebral blood flow . myocardial infarction   deficiency of left ventricular function, ileus , Liver and kidney failure, hemodialysis   (development of arterial hypotension), 14-40 weeks of pregnancy, age less than 18 years, co-administration Digoxin . beta-blockers .

Side effects

• From the circulatory system: Arrhythmia . tachycardia , Peripheral edema, excessive vasodilation (decreased blood pressure, worsening heart failure, flushing of the face, the sensation of heat), a strong drop in pressure, fainting. A small number of patients at the beginning of treatment or after a dose increase may appear attacks angina   and in very rare cases - myocardial infarction .
• From the nervous system: dizziness, headache, weakness, fatigue, drowsiness. During long term treatment preparation in large doses - paresthesia , Trembling, extrapyramidal disorders   (mask-like face, ataxia, changes in gait) depression .
• From the digestive system: dry mouth, flatulence . dyspepsia , Increased appetite. Less - gingival hyperplasia, which disappears after discontinuation of treatment. With prolonged use - liver damage ( cholestasia Increase in liver enzymes).
• From the musculoskeletal system: myalgia . arthritis Swelling of the joints, cramping limbs.
• Hypersensitivity reactions: rare - hives . itch . autoimmune hepatitis . dermatitis . anaphylaxis .
• From the hematopoietic system: leukopenia . anemia . thrombocytopenia . agranulocytosis .
• On the part of the excretory system: increase diuresis , Renal failure (in patients with renal insufficiency).
• Other: rarely - blurred vision, temporary gynecomastia . hyperglycemia, galactorrhoea, bronchospasm, weight gain.

Instructions for use corinfar

Instructions for use Corinfar Retard   and Corinfar   It explains how to take the medicine. The tablets are used orally after a meal, do not raskusyvaya and drinking water in sufficient quantities. Simultaneous reception with food inhibits adsorption   active substance from the intestine. Typically, the drug is taken in the morning and in the evening, but it is worth remembering that Corinfar DNA 40 mg can be used only once a day.

The dose and frequency of dosing is chosen individually by the attending physician, considering the severity of the disease and other clinical aspects.

At vasospastic angina   and angina : 1 tablet Corinfar Retard   or Corinfar   (depending on the severity and individual sensitivity), 2 times per day. When a weakly pronounced effect dose is slowly increased to two tablets 2 times per day.

Essential hypertension : 1 table. Corinfar Retard   or Corinfar   (depending on the severity and individual sensitivity), 2 times per day. When a weakly pronounced effect dose is slowly increased to two tablets 2 times per day.

When double assignment of the drug per day interval between doses should be on average 12 hours. Corinfar DNA   It takes the same time of the day at intervals of 24 hours preferably before lunch and 1 tablet (40 mg) once a day.

Overdose

Symptoms: facial flushing, headache, bradycardia / tachycardia , Strong long-term reduction in blood pressure, suppression sinus node . In severe cases - syncope, coma .

Therapy: symptomatic. As a general rule, carry out gastric lavage use Activated carbon . Antidote will be calcium supplements - intravenous 10% solution calcium chloride   or calcium gluconate . If a strong decrease in blood pressure is recommended a slow intravenous dobutamine, dopamine, norepinephrine,   or adrenaline . If you have heart failure - intravenous strophanthin . With the development of arrhythmic conditions   - izoprenalin . atropine .

Hemodialysis   ineffective in case of an overdose, it is recommended plasmapheresis .

Cooperation

It should take into account the following effects from interaction with drugs listed below:

• from tricyclic antidepressants, antihypertensives, vasodilators   - Increase the hypotensive effect;
• from beta-blockers   - Marked decrease in blood pressure;
• from diltiazem   - The suppression of metabolism nifedipine ;
• from quinidine   - A sharp decline in the concentration of quinidine   in blood after cancellation nifedipine   - A sharp rise in the content quinidine   in blood;
• from digoxin . theophylline   - Increase in theophylline   and Digoxin   in the blood (it is likely signs of an overdose   digoxin );
• from quinupristin, dalfopistinom, cimetidine   - An increase in the concentration of nifedipine   in blood;
• from rifampicin   - Accelerated metabolism nifedipine ;
• from cephalosporins, tacrolimus   - Increase in the blood concentration of the latter;
• from phenytoin   - Easing effects nifedipine ;
• with drugs inhibiting system P450   ( macrolides, fluoxetine, nefazodone, protease inhibitors,   antifungals) and valproic acid   - Increase in nifedipine in blood;
• from carbamazepine . phenobarbital   - Reduction of nifedipine   in blood.

Terms of sale

In Ukraine, the drug can be bought only on prescription in Russia, the drug is in the list of non-prescription.

Storage conditions

Store at temperatures up to 30 degrees in the original packaging. Keep away from children.

Shelf life

5 years.

Cautions

• Discontinue therapy drug should be gradually.
• Early treatment may occur angina Especially if recently abrupt withdrawal beta-blockers   (they must also be lifted gradually).
• In severe Heart Failure   Corinfar should be dosed with caution.
• In patients with severe obstructive cardiomyopathy   there is a risk of increasing the frequency, severity and duration of attacks angina   after use nifedipine ; In this case the preparation is canceled.
• In patients with severe renal failure Which are at hemodialysis Have high blood pressure and decreased blood volume, a drug is recommended to be used with caution, as there is a risk of a sharp drop in blood pressure.
• If you are planning surgery with general anesthesia, the anesthetist should be informed about the reception nifedipine .
• The drug affects the ability to drive vehicles. We must be careful when driving.

Analogs

The preparation of the pressure has Corinfar INN (International Nonproprietary Name) nifedipine . Known pressure tablets having a similar composition: Cordipin, Nikardiya, Nifedipine, Osmo-Adalat, fenigidin .

With alcohol

The drug is not compatible with alcohol.

During pregnancy (and lactation)

The drug has a teratogenic effect on this show tests carried out on animals.

1 trimester of pregnancy is a strict contraindication to receiving the drug, and in 2-3 trimester and during breast-feeding is necessary to exercise great caution with the use of the drug.

Reviews corinfar

Reviews Corinfar Retard   and Corinfar As well as reviews Corinfar DNA   very contradictory. Along with reports about the wonderful effect of the use of the drug at high pressure, there are responses indicating a lack of therapeutic effect when hypertension From what Corinfar tablets should help. This is due to a large amplitude of opinions variability sensitivity to the drug among patients (in clinical practice is quite common).

Price corinfar

Cost Corinfar Retard   in Russia is 157 rubles per pack of 50 tablets, the same amount of conventional Corinfar   It will cost 71 rubles. And the price Corinfar DNA   approximately 340 rubles per 50 tablets of the drug.

In Ukraine, the average price of Corinfar . Corinfar Retard   and Corinfar DNA   the number of 50 tablets are 25, 84, and 103 hryvnia, respectively.