Description overdue on 06/30/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Kordafleksa (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Synonyms
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Coated tablets contain 10 mg nifedipine   each as an active substance. Auxiliary substances: polyvinyl butyral   at 0, 7 mg; talc (1 mg); 0, 3 mg magnesium stearate ; 4 mg hydroxypropyl ; lactose monohydrate   (15 mg); Croscarmellose sodium   (13 mg); microcellulose (46 mg). The shell consists of hypromellose - 2, 63 mg; Titanium Dioxide C.I. 77891   - 0, 82 mg; yellow iron oxide   - 0, 3 mg magnesium stearate   - 0, 25 mg.

Tablets having a prolonged action, with a film coating containing the same active ingredient but at a dose of 20 mg. As auxiliary in each such substances are: microcellulose (99 mg); lactose monohydrate   (30 mg); Croscarmellose sodium   (26 mg); copolymers of methyl methacrylate and ethyl methacrylate in a ratio of 1: 2 (1, 9 mg); talc (2 mg); magnesium stearate (0, 6 mg); giproloza (0, 5 mg). The film coating is made from hypromellose - 5, 26 mg; titanium dioxide   - 1, 64 mg; red iron oxide - 0, 6 mg; Magnesium stearate - 0, 5 mg.

Product form

There are two versions of the drug release forms:

• Coated tablets, each weighing 10 mg . Every 100 tablets are placed in a vial of brown glass. The vials individually packed in cardboard boxes.
• Film-coated tablets Having prolonged effect. Each tablet weighs 20 mg. Lay 30 or 60 tablets in brown glass bottles. Bottles must be corked plastic lids that have control of the first opening. The bottle is packed in a cardboard box.

Pharmacological action

Hypotensive (lowers arterial pressure ) And antianginal effects.

Pharmacodynamics and pharmacokinetics

Nifedipine   It is a selective blocker of slow calcium channels, among the derivatives of 1, 4-dihydropyridine. Its effect is to reduce the current of extracellular calcium ions into cardiomyocytes and smooth muscle cells of arteries. Also nifedipine can enhance renal blood flow, causing wherein moderate natriuresis .

After a single oral Kordafleksa having prolonged action clinical effect usually develops within 20 minutes, the effect lasts from 12 to 24 hours.

Upon reception quickly, almost completely (at least 90%) is absorbed from the digestive tract. A bioavailability is in the range 40-70%.

The maximum concentration   the active substance contained in blood within 30-60 minutes after dosing.

After receiving a single tablet, which has a prolonged action, therapeutic plasma concentration is reached after an hour and kept at the same level up to 6 hours, 30-36 hours, further gradual decrease in concentration.

Nifedipine has the property of binding to plasma proteins, in particular, albumin Penetrate the blood-brain barrier (in a small amount - less than 5%) via placenta It may be allocated to breast milk.

The half-life of 2 hours for 10 mg tablets, pills for having sustained release 20 mg - about 3.8-16.9 hours.

Indications

Indications Kordafleksa associated with cardiovascular disease. Arterial hypertension   varying severity, including hypertensive crises   - Basic, from which tablets Kordafleks help.

Also, these tablets are administered to patients suffering coronary heart disease Including cases of vasospastic and stable angina .

Contraindications

Contraindications:

• intolerance nifedipine And other derivatives 1, 4-dihydropyridine , Additional components that make up the tablets;
• hypotension ;
• unstable angina ;
• the presence of current or recently acute myocardial infarction Expressed aortic stenosis ;
• idiopathic subaortic stenosis ;
• congestive heart failure   the period of decompensation;
• children's age.

With extreme caution appointed elderly patients, those who have violated the kidneys, patients diabetes .

Side effects

Kordafleks generally positive tolerated. Side effects are rare, usually at the beginning of treatment (and then they can become weaker or disappear).

There are options such side effects:

• At the heart and blood vessels : Lowering blood pressure, hyperemia   face and trunk, swelling of the extremities , Accelerated heart rate, paradoxical angina , Development acute heart failure .
• In the nervous system : fatigue . dizziness . weakness . emotional lability , Sleep disturbances, headache, tremor . paresthesia .
• In the gastrointestinal tract : Occurrence Heartburn . nausea . vomiting . flatulence , Violations of the chair, dryness or inflammation of the mucous membranes of the mouth, intrahepatic cholestasis As well as increased activity of certain liver enzymes.
• In the circulatory system : thrombocytopenia . leukopenia . anemia .
• On the urinary system : Increase daily urine output, nighttime urination , Reduced renal function.

Allergic reactions may occur in the form of hives . exanthema . pruritus .

Instructions for use Kordafleksa (method and dosage)

The drug is taken orally. The coated tablets of 10 mg swallowed whole before meals, washed down with water.

The dosage is determined individually, as is highly dependent on the severity of the disease, the type of disease and the body's response to therapy. Start with 1 tablet (10 mg) three times a day. Between the doses should be held for at least 2 hours. The maximum dose per day - 40 mg.

The tablets have a prolonged effect, a film cover swallowed whole, washed down with water. The initial dose - 1 tablet 2 times a day. The daily dose in any case, divided into 2 doses, which should be observed between the 12-hour interval.

According to the instructions for use Kordafleksa, the abolition of the drug should be carried out gradually.

Overdose

In case of overdose nifedipine may have such effects:

• hypotension ;
• chest pain (like attack angina );
• tachycardia ;
• loss of consciousness;
• collapse ;
• or ventricular nodal arrythmia ;
• bradycardia .

In severe cases, may develop metabolic alkalosis , Cardiogenic shock, pulmonary edema, hypoxia . hyperkalemia As well as disorders of consciousness that can go in whom .

Cooperation

Kordafleks not be prescribed with medications containing alcohol.

Perhaps the development of orthostatic hypotension   when used with methyldopa . clonidine As well as prazosin and oktadin .

Cimetidine . Ranitidine   and tricyclic antidepressants are potentiating antihypertensive effect .

When combined with Kordafleksa theophylline and digoxin   We need to carry out the control of the plasma concentrations of these drugs, as it can rise.

Phenytoin , Calcium supplements and rifampicin   reducing effect nifedipine .

Kordafleks reduces the rate of excretion vincristine That increases the risk of side effects. Therefore dose adjustment is needed.

Erythromycin . diltiazem , Grapefruit juice in large quantity, azole antimicrobials when taken with nifedipine significantly slow down its metabolism.

Terms of sale

The drug is sold only by prescription.

Storage conditions

The temperature of the room in which the drug store must not exceed 30 ° C.

Shelf life

5 years.

Kordafleksa analogues (medicines that have a similar effect)

Analogues of such preparations are: Adalat . Vero Nifedipine . Kaltsigard Retard . Zanifed . Kordafen . Kordafleks Retard . Cordipin . Cordipin Retard . Cordipin XL Corinfar . Nifedikap . Nifedipine   and some other preparations.

Kordafleks Retard is particularly close to the characteristics of the pharmaceutical and therapeutic applications.

Synonyms

Nifedipine . Kordafen .

Babies

Not used in pediatrics.

With alcohol

It prohibited the simultaneous use.

During pregnancy and lactation

It may be assigned at the time of pregnancy   only the ineffectiveness of other drugs.

During lactation should not be given drugs containing nifedipine .

Reviews Kordaflekse

Reviews there are different, since the drug is widely used. If we look at the reviews of doctors of the application of Kordafleksa, they note its relatively short-lived effect on the body, therefore it should be used at least 2 times a day. Plus, the drug is that it is not addictive.

Price Kordafleksa where to buy

Price for 10 mg tablets is 72-95 rubles per 10 pieces, for 20 mg tablets - 63-139 rubles per 30 pieces, 74-168 rubles per 60 pieces.