Description overdue on 08/09/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions ramipril (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Depending on the form of a composition of one capsule contains 2, 5, 5 or 10 mg. actively acting drug ramipril.

Furthermore, in a preparation containing such compounds as an auxiliary magnesium stearate   (1 mg.) And lactose monohydrate (96, 5 mg.).

Product form

Ramipril - is capsules or tablets containing 2, 5, 5 or 10 mg. the same name of the drug.

Pharmacological action

The drug has hypotensive, natriuretic, cardioprotective and vasodilatory effects.

Pharmacodynamics and pharmacokinetics

Inherently Ramipril - a drug related to ACE inhibitors   (angiotensin converting enzyme), i.e. to a group of compounds which are widely used in the treatment of kidney , and heart failure.   Due drug to the drug in the body begins to produce ramiprilat Which in turn inhibits the conversion angiotensin I to angiotensin II And inhibits their synthesis in tissues.

The action of the drug compound in the organism lowers the concentration Angiotensin II Which is powerful enough to vasoconstrictors . By eliminating feedback, bearing negative, when released   Renin Decreases secretion aldosterone Thereby reducing the total peripheral vascular resistance .

At the same time, increased stress tolerance by increasing cardiac output per minute and resistance vessels of the lungs . The drug has an effect on blood vessels of the kidneys And starts the process remodeling of the cardiovascular system . Ramipril reduces the total resistance   peripheral renal vessels, muscles, liver, skin and brain , Enhances blood flow in organs .

The antihypertensive effect   drug begins within a few hours after his admission. With regular use of the drug for 4 weeks there is a gradual increase hypotensive activity , Where the normal level is maintained during long-term treatment for several years.

The drug reduces the incidence of recurrent stroke, myocardial infarction patients after stroke or previously transferred suffering from diseases peripheral vascular , and CHD . In addition, the drug helps to avoid the development of   Diabetes in patients with a history of risk factors such as the hypertension, microalbuminuria, elevated cholesterol and low LPVR (high density lipoprotein).

Ramipril is absorbed by 60% in the body, wherein the meals have absolutely no effect on the degree of absorbability of the drug. For effective drug of the drug the patient should work properly liver , Which was destroyed in ether linkages and forms   ramiprilat Accelerating the process of formation metabolites.

After 2 hours after taking the drug in the body reaches maximum activity concentration of the active compound which is completely removed after 17 hours from the feces and urine.

Indications

Use the medication recommended for:

• Heart Failure chronic nature;
• nephropathy ;
• hypertension ;
• kidney disease Wearing a diffuse character.

Everything else, Ramipril is used in the treatment of patients undergoing heart attack, stroke,   and transluminal angioplasty and   coronary artery bypass surgery .

Contraindications

Do not use the drug if hypersensitivity   to Substances-ACE inhibitors At hypotension . hyperkalemia . renal failure And while pregnancy and in   lactation. In addition, it is recommended to avoid ramipril in the treatment of children under the age of 18 years and older patients.

Restrict the use of the drug is in the presence of a history angioneurotic edema, suppression of severe autoimmune disease, poor circulation, atherosclerosis, stenosis after kidney transplantation, diabetes and some lung disease, hyponatremia, on dialysis .

Side effects

During the administration of the drug may cause side effects such as: heart failure, hypotension, angina, myocardial infarction, syncope, vertigo, arrhythmia, vasculitis, thrombocytopenia, nausea and vomiting, diarrhea, dispersion, constipation, pancreatitis, dysgraphia, abnormal liver function, jaundice, increased salivation, dizziness, headaches, fatigue, amnesia, depression state, drowsiness, neuropathy, tremor, sleep disorders, hearing loss, liver necrosis, blurred vision, cough, shortness of breath, sinusitis, pharyngitis, rhinitis, laryngitis, photosensitivity, as well as weight loss, angioneurotic edema, fever.

Instructions ramipril (method and dosage)

In accordance with the instructions for use of ramipril, a drug begin to take an oral dose of no more than 2, 5 mg. per day. Mode of use of the drug, as well as dosage, will vary depending on the treating physician, and the complexity of the disease and the patient's condition.

Overdose

In case of overdose in patients experience the following symptoms: hypotension, angionevrologichesky edema, circulatory problems, heart attack, coupled with thromboembolic complications.

For the treatment of the consequences of the wrong dosage of the drug washed stomach , And implement measures to increase the volume circulating blood And completely stop or reduce the dose of ramipril.

Cooperation

The therapeutic effect of the drug significantly enhance antihypertensives . To avoid hypoglycemia . hyperaldosteronism , Increasing the risk of neutropenia The medicine may not be used in conjunction with antidiabetic drugs . diuretics And means mielodepressivnogo exposure . potassium-containing additives   and salt substitutes.

Terms of sale

By prescription.

Storage conditions

The drug is stored in a place protected from humidity and light place, out of reach of children at a temperature of 25 C.

Shelf life

3 years.

Cautions

Before using the product, as well as during the actual treatment, patients (especially diseases connective tissue diffuse nature And receiving Allopurinol   and immunosuppressants ) Are recommended for regular inspection kidney and electrolyte composition of blood , Including peripheral .

Patients with sodium deficiency   before the therapeutic treatment is to normalize water-electrolyte performance.   During the use of drugs banned from hemodialysis   with help polyacrylonitrile membranes .

Analogs of ramipril

The main counterparts of ramipril can be considered: Amprilan, Vazolong, Korpril, Dilaprel, Pyramus, Ramigamma, Ramipril-NW Ramikardiya, Tritatse Hart.

Synonyms ramipril

Korpril Hart, Tritatse

Babies

Not used in the treatment of children under the age of 18 years.

During pregnancy (and lactation)

Because the drug has a negative impact on the development of the fetus, especially during the first trimester, it is strictly contraindicated for use during pregnancy. If the patient becomes pregnant during treatment directly, immediately abandon the use of ramipril.

Reviews of ramipril

Most patients using the original drug and not a budget for the cost of analogues, including domestic producers leave positive feedback for ramipril. However, many point out as a negative factor in the presence of the drug over a long list of side effects.

Price ramipril, where to buy

Price ramipril varies from region, however, the average package comprising a capsule or tablet, nominal volume 2, 5 mg. It will cost 200 rubles.