Description overdue on 06/24/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Torvakarda
• Contraindications
• Side effects
• Instructions for use Torvakarda (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

1 tablet contains 40, 20 mg or 10 mg atorvastatin .

Additional ingredients: krokskarmelloza sodium, magnesium stearate, microcrystalline cellulose, magnesium oxide, hydroxypropyl cellulose, silica, lactose monohydrate.

The shell consists of macrogol, hypromellose, titanium dioxide and talc.

Product form

Tablets coated in white, 10 pcs. in blisters.

Pharmacological action

It refers to a group statins   and having lipid-lowering effect . Selectively and competitively inhibits the enzyme involved in the synthesis of cholesterol .

Triglycerides   and cholesterol are components of atherogenic lipoproteins   in the liver, blood and then transferred to the periphery. When interacting with the receptors Lipoprotein low density they are converted to these lipoproteins.

Due to the inhibition of HMG-CoA reductase is reduced and the level of lipoprotein cholesterol   in blood. Reduced synthesis of LDL and increases the activity of their receptors.

The drug can reduce the amount of LDL in the homozygous hypercholesterolemia   hereditary nature when other drugs have no effect.

The drug lowers cholesterol by 30-46%, atherogenic lipoproteins in the 41-61%, triglycerides by 14-33% and increases lipoprotein having antiatherogenic   properties.

Pharmacodynamics and pharmacokinetics

The maximum blood concentration of the drug occurs within 60-120 minutes. Food intake reduces the duration of intake but decrease cholesterol   comparable to that without food. In case of application in the evening, the drug concentration is lower than when the morning.

C blood proteins binds on 98%. It is metabolized in the liver with the formation of active metabolites.

Excreted in the bile, the half-life is 14 hours. The efficacy is maintained by active metabolites to 30 hours. When hemodialysis is not displayed.

Indications Torvakarda

Tablets Torvakard - from what they are?

The medicine is used together with diet for:

• reducing the level of cholesterol , Atherogenic lipoproteins, triglycerides, apolipoprotein B, and an increase in the amount of HDL cholesterol in hypercholesterolemia, heterozygous and combined hypercholesterolemia (Types IIa and IIb of Fredrickson);
• treatment of patients with increased content triglycerides   in blood (IV type of Fredrickson) and type III according to Fredrickson (disbetalipoproteinemiya), if the diet does not work;
• reducing the amount of cholesterol and LDL in homozygous hypercholesterolemia family type ;
• treatment of diseases of the heart and blood vessels in the presence of elevated factors of coronary heart disease ( hypertension Patients older than 55 years, stroke   in anamnesis, albuminuria , Left ventricular hypertrophy, smoking, peripheral vascular disease,   CHD   in family, diabetes ).

The most frequent indications for use Torvakarda - secondary warning myocardial infarction Death, revascularization , Stroke in the background dyslipidemia .

Contraindications

• severe liver disease;
• elevated levels of transaminases   in blood;
• hereditary glucose intolerance and lactose, insufficiency of lactase;
• women of childbearing age, not using contraception ;
• pregnancy   and lactation ;
• to children till 18 years;
• idiosyncrasy.

Gently used in metabolic disorders and metabolic hypertension . alcoholism Transferred liver disease sepsis , Changes in fluid and electrolyte balance in the diabetes . epilepsy , Injuries and major operations.

Side effects

Nervous system: insomnia, headache, depression . sleep disorders . paresthesia . ataxia . Neuropathy .

Digestive tract: stomach pain, dyspepsia , Nausea and vomiting, violations of the chair, changes in appetite, pancreatitis   and hepatitis . jaundice .

Musculoskeletal system: pain in joints and muscles, back pain, muscle cramps in the legs, myositis .

Allergic symptoms:   hives , Itching, anaphylactic shock , Erythema multiforme, angioedema , Lyell's syndrome.

Abnormalities in laboratory parameters: changes in the level Glucose Increase in activity liver enzymes   and creatine   in blood.

Among other manifestations may be edema peripheral tissues, chest pain, tinnitus, hair loss, weakness, weight gain, impotence , Renal failure secondary nature, reduction in platelet count.

Tablets of cholesterol in some cases led to depression , Sexual dysfunction, rare cases of lesions of the connective tissue of the lungs, diabetes   (It depends on the development of risk factors - fasting glucose, blood pressure, body mass index, hypertriglyceridemia ).

Instructions for use Torvakarda (method and dosage)

During treatment, the patient must comply lipid-lowering diet .

Therapy begins with 10 mg per day, then increased to 20 mg. Daily therapeutic dose of - from 10 to 80 mg. Dose picked based on laboratory parameters and individual features.

The drug is taken without regard to meals.

Prior to the reception, and if necessary, dose adjustment is carried out laboratory control of lipid levels.

The effect of the application occurs within 14 days.

For the treatment of patients with homozygous hypercholesterolemia   one of the few drugs that give the effect is Torvakard, instructions for use clearly defines the daily dose, which is 80 mg.

Overdose

If signs of overdose symptomatic therapy.

Cooperation

Use of preparations, the oppressor the metabolism of, mediated enzyme CYP450, Erythromycin , Antifungal and immunosuppressive agents, fibrates, cyclosporine . clarithromycin . nicotinamide . nicotinic acid   Torvakarda concentration in the blood increases. This increased the risk of myopathy, so you need to control the level of creatine kinase in the blood.

Joint acceptance of funds from aluminum hydroxide   or magnesium   Torvakarda reduces the concentration, but this does not affect efficiency.

Combination with colestipol   reduces the concentration atorvastatin But their joint hypolipidemic effect   exceeds individually.

Cimetidine . spironolactone . ketoconazole   It increases the likelihood of reducing the level of steroid hormones.

Receiving oral contraceptives   and a daily dose of 80 mg Torvakarda increases the amount of ethinyl estradiol in the blood.

Use in combination with digoxin   reduces the concentration of the latter 20%.

Terms of sale

Prescription.

Storage conditions

In a place that is protected from children.

Shelf life

4 years.

Cautions

Before treatment is necessary to try to reduce cholesterol diet, medication obesity   and concomitant diseases, increasing physical activity.

During treatment requires monitoring of levels of AST and ALT. The first control is carried out before and after 6 weeks and 3 months after the start of treatment and after dose adjustments and one every six months. If the enzyme is increased more than 3 times, the preparation is canceled.

Admission Torvakarda can cause weakness and muscle pain ( myopathy ) And increase of CPK in the blood. When the muscle pain or weakness, combined with the rise in temperature should see a doctor.

The medicine is canceled when the risk of renal failure due to rhabdomyolysis . This can be a trauma, extensive surgery, metabolic and electrolyte balance, hypotension , Severe infection,   convulsions .

Admission Torvakarda can lead to Diabetes   in patients who have an elevated risk. But it is worth remembering that the benefits of statins higher risk of diabetes, there is no need to remove the drug, and patients at risk should be under constant medical supervision.

Analogs Torvakarda

Torvakarda analogs on the market in large numbers: Zakora . Vasilip . Crestor . Lovastatin . Rovakor . Pravastatin . Rosuvastatin . Simvastatin . Atorvastatin . Lipitor . Atoris .

Price analogues is 120 rubles. 30 Tab. Atorvastatin   Russian production up to 3606 rubles. 28 tablets of the drug Crestor   40 mg.

Synonyms

Atorvastatin . Lipitor . Atoris .

Babies

Contraindications to 18 years.

During pregnancy and lactation

Is contraindicated due to the high risk of fetal abnormalities. If there is a need for treatment during lactation, breast-feeding should be discontinued.

Reviews Torvakarde

Those reviews of Torvakarde that are available in the forums suggest a sufficient efficacy. It is widely prescribed for lowering cardiologists cholesterol   and the protection of patients by stroke   and heart attack . After 1-2 months of use there is a significant reduction of cholesterol levels. Some women indicate a pleasant side effect - weight loss.

Among the shortcomings can be called that a cure can cause cholesterol insomnia   and itchy rashes on the body.

Price Torvakarda where to buy

The cost of of the drug in pharmacies Russia makes from 276 up to 320 rubles. 30 tablets of 10 mg. Price Torvakard 20 mg 90 tablets on the average 1025 rubles. And the pack of 90 tablets of 40 mg dose is 1286 rubles.