Description overdue on 01.12.2011

The preparation Enap   the impact of antihypertensive   which occurs due to the blockade of ACE anaprilatom . Thus, under the action of the drug in the blood level is reduced Angiotensin II   and aldosterone , There is stimulation vasodepressor systems   organism. The drug effect on total peripheral resistance, reducing it, so that the left ventricle is working better. This effectively prevents damage to cells infarction . The body activates more coronary hemodynamics, cardiac muscle shows high resistance hypoxia And ventricular Arrhythmia   much less common. During dosing enap area postinfarction necrosis   reduced, and metabolism of the heart muscle is improved. Thus, this drug has no effect on heart rate.

Patients with hypertension   and chronic cerebrovascular diseases   the drug is prescribed to lower renovascular resistance, improve blood circulation in the kidneys. Thus sodium and water are excreted from the body, and potassium - is maintained. In view of the effects the drug has a positive effect on the functioning of the kidneys, prevents the emergence of   and chronic renal failure. Constant reception of the drug helps a marked improvement in the daily life of patients with cardiovascular diseases. Thus the efficacy of the drug does not affect enap sex, age of the patient, and the level of Renin   in blood plasma. The drug does not violate the sexual function. Provided a single dose of its drug effect lasts for 24 hours.

Indications and methods of use of the drug:

Enap is prescribed to patients with any stage And when renovascular hypertension   and all degrees of heart failure. In the case of severe heart failure and asymptomatic left ventricular dysfunction, the drug effectively used to slow the progress of heart failure. The drug acts effectively in therapy and prevention of ischemic infarction and unstable angina .

The tablets should be consumed without chewing, with the meal period is irrelevant. Starting dose usually is 5 mg per day. Guided by the individual characteristics of the disease, as well as the condition of the patient, the specialist can increase the daily dose to 10-20 mg Enap, and in particularly difficult conditions - up to 40 mg. Some patients suffering from hypertension, early treatment can be rather significant drop in blood pressure.

Patients with congestive heart failure is first administered a daily dose of 2 and 5 mg. If necessary, the dose can be gradually increased as long as there occur the effect of therapy. The maximum daily dose Enap - - 40 mg, divided into two steps.

Carefully monitor the dose should be patient, that before initiating therapy Enap have used diuretics. This raises Fig symptoms of hypotension. Therefore daily dose should not exceed 5 mg.

In appointing the drug dose for children is adjusted individually. Thus children whose weight is 20 to 50 kg as an initial dose should not consume more than 2, 5 mg. Children whose weight is 50 kg or more, can start taking the drug with 5 mg per day.

Contraindications and possible side effects:

Do not take enap those who have a high sensitivity enalapril   or its metabolite enalaprilate . During pregnancy, it is not recommended to take Enap. His appointment is possible only in very severe cases.

As the side effects Nervous System   It may appear high fatigue, headaches, dizziness, changes in taste. In work   may occur diarrhea . vomiting . nausea . In work blood supply   sometimes manifested agranulocytosis . anemia , Lower level leukocytes   and Platelet . hypotension . orthostatic reactions . It is also possible to change the pattern of blood due to higher content creatinine . urea   and transaminases , A manifestation of muscle cramps and allergic reactions. With an overdose of the drug may cause hypotension.

Specific recommendations:

Drinking alcohol during treatment may cause Enap hypotension . Keep this drug must be in a temperature range from 4 to 25 degrees, protected against the ingress of moisture. Keep away from children.