Description overdue on 05/30/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications magnerot
• Contraindications
• Side effects
• Instructions for use magnerot (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Tablets contain 500 mg magnesium orotate (when converted to a mass fraction of pure magnesium - 32.8 mg) and a number of auxiliary substances:

• Microcrystalline cellulose - 67.5 mg.
• Lactose monohydrate - 50 mg.
• Povidone K 30   (full pharmacological name - low-molecular medical polyvinylpyrrolidone ) - 30 mg.
• Corn starch - 22.5 mg.
• Talc ordinary - 18.75 mg.
• Sodium carmellose   - 10 mg.
• Colloidal silicon dioxide - 2.5 mg.
• Magnesium stearate   - 1.63 mg.
• Sodium cyclamate - 1.5 mg.

Product form

On shelves pharmaceutical medicament is presented in tablet form white color and a circular shape on both sides of which there is a characteristic strip. Magnerot Magne B6 or packed in a contour-well plates for 10 tablets each. The cardboard box is placed 2 or 5 packs of container.

Pharmacological action

Magnesium - is a macrocell, which is involved in all aspects of cell life. Thus, it is not possible without full metabolism Because it is an indispensable part of the protein, energy, carbohydrate and mineral metabolism. Also, the magnesium participates in the construction of nucleic acid strands before replication.

Magnesium - natural calcium antagonist   (ie the elements are opposed to each other), it has a depressing effect on neuromuscular transmission, helps to improve the resistance of cardiomyocytes (heart cells) stress.

Since the drug is included orotic acid , That the chemical bonds of magnesium and ATP in cells is significantly enhanced, thus the drug promotes the growth of cells throughout the body. With a more efficient delivery of energy in the cell processes are regulated by the endogenous lipid metabolism.

Pharmacodynamics and pharmacokinetics

Chemical feature magnesium orotate   - Disseminated metabolized, ie the drug is absorbed in different ways. The largest number is in the ionized state in the systemic circulation and excreted in the urine by the kidneys. About 30 percent of magnesium salts bind to plasma protein, extends the finding that drug into the body. 10-15 percent in the form of salts accumulate in the bone formations or intracellular spaces, where included in the connection DNA . RNA   and ATP .

Orotic acid is metabolized mostly in the liver. With it turns out uridinmonofosfat Which then is part of the intermediate pyrimidine synthesis. Thus, the biologically active drug component may be displayed in three ways:

• through the intestines;
• kidneys;
• sweat glands.

It should be noted that Magnerot - very active drug. The main active ingredient is relatively easy to penetrate the blood-brain and placental barrier. Also determined Magnesium Orotate   and in breast milk during lactation.

Indications magnerot

Usually the drug is indicated for chronic heart failure   or Arrhythmia Which is due to a deficit of salts or magnesium ions in the body. Also Magnerot effectively resists spastic states , Progression atherosclerosis Deficient arteritis . angioneurotic collapse . Magnesium salts correcting dyslipidemia Reducing certain fraction of endogenous fat. As a means of preventing Magnerot appointed to conservative therapy coronary heart disease   ( angina . myocardial infarction ).

Indications magnerot may be enhanced by the digestive pathology when magnesium food is not absorbed in the gastrointestinal tract or conditions requiring large amounts of active substance. The latter include:

• chronic alcoholism ;
• pregnancy ;
• duration of the current physical inactivity ;
• chronic stress ;
• in the treatment to avoid side effects of magnesium deficiency.

Contraindications

Magnerot - active drug ingredient with strong acting, because in certain situations by including it in the course of treatment must be abandoned. For example, it is not recommended to use in:

• Impaired urinary function of the kidneys.
• Cirrhosis Which is burdened with ascites (an extreme stage of pathology).
• Urolithiasis   or genetic predisposition to the formation of stones in the urinary system.
• Atrioventricular block I-II level with a strong bradycardia .
• Glucose-galactose malabsorption   or galactosemia .
• Intolerance or hypersensitivity to the components of the composition.
• Children under 18 years old.

Side effects

Tablets Magnerot usually well tolerated, but with self-administration of large doses may dyspepsia   gastrointestinal - unstable stool, diarrhea . Reduction of complications cropped received a one-time dose.

Known clinical cases where, because the dosage of magnesium developed allergic skin reactions   as hives Characteristic exanthema , Hyperemic and papular rash or pruritus . In this case, it is recommended to contact your doctor, so the dosage rate of conservative treatment has been corrected properly.

Instructions for use magnerot (method and dosage)

The drug is intended for oral . In order to greatly improve the efficiency of the drug is recommended to be taken orally 1 hour before meals. The tablets should be taken with plenty of drinking water. The duration of the conservative course of treatment prescribed by the doctor to each clinical case, but there is a common regimen. Originally used two tablets three times a day during the first week, then the dosage is reduced to one tablet per-reception.

The maximum daily dose of magnesium orotate is 3000 mg (amount of active substance is contained in six tablets).

The somnambulistic practice also used the drug and magnesium in particular Magnerot, instructions for use in this case, is undergoing several changes. Those who suffer from night cramps usually assigned one-time fee of 2-3 tablets before bedtime.

Overdose

When using high doses of the drug possible magnesium intoxication However, this pathologic condition rarely develops in normal renal function.

Acute excess of magnesium in the systemic circulation causes:

• Strong language dyspeptic syndrome   ( nausea . vomiting . diarrhea , stomach ache).
• Violation of patency of biliary tract.
• Paralysis of the respiratory muscles.
• Violation of the stomach and atrioventricular conduction.

In order to stop excess drug, should be given a large amount of Potassium (on the principle of natural antagonism effects of magnesium intoxication gradually come to naught) and conduct periotnealny or extracorporeal dialysis . If necessary, the treatment of overdose is complemented by cardiopulmonary resuscitation.

Cooperation

Do not use the drug in combination with Magnesium iron salts . sodium fluoride   and tetracyclines Because their intestinal reabsorption is reduced during the course magnerot.

When used together with sedatives . neuroleptics or tranquilizers   (drugs that inhibit the central nervous system) potentiates their pharmacological action on the body.

The combined application antihypertensive and antiarrhythmic magnerot on the background, greatly enhanced expression of the therapeutic effect (possible antihypertensive or bradycardic crises ).

Terms of sale

The drug is released in a pharmacy without a doctor's form of the receptor.

Storage conditions

The medicine should be stored in a dry place out of reach of young children, at a temperature below 25 degrees Celsius.

Shelf life

5 years from date of manufacture.

Analogs magnerot

Asparkam . Panangin . Megamag . Price magnerot analogues are in the lower price range, for example, Asparkam online pharmacies can be purchased for 20 hryvnia.

Magnerot during pregnancy and lactation

Objectively magnerot indications for use during pregnancy really exist, but the wrong dosage of the drug can lead to catastrophic consequences such as miscarriage   and miscarriage . Because drug use is justified only if the potential benefit to the mother of the future is higher than the risk to the fetus.

It should be noted that the responses during pregnancy say the drug is generally well tolerated, with no apparent complications (see. " Reviews magnerot ").

Reviews magnerot

Reviews magnerot forums for evidence of the positive therapeutic effects of the conservative course of this drug. So often say that the state was better stressful situations   do not cause such a strong increase in heart rate, neuromuscular transmission has improved, which is reflected in the sporting life of the patients.

Satisfied with drug and medical part of the Internet audience, as when it is used to a great extent reduced the risk of developing coronary heart disease   (diseases of the cardiovascular system has the highest mortality in therapeutic departments), which is confirmed by statistics.

It is also important reviews during pregnancy - usually Magnerot well tolerated even at such a critical period in the life of a woman, but many point out that at the time of medical treatment should always be under the supervision of qualified medical personnel.

Price tablets Magnerot

In Ukraine, the cost of the drug an average of 60-70 hryvnia. In the Russian Federation magnerot price varies from 150 to 250 rubles a package with two blisters (20 tablets).